Results 111 to 120 of about 5,306,314 (299)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants

Frontiers in Plant Science, 2019
Based on recent in vitro data, a relatively large number of the plant nitrate transporter 1/peptide transporter family (NPF) proteins have been suggested to function as gibberellic acid (GA) transporters.
Nikolai Wulff, Heidi Asschenfeldt Ernst, Morten Egevang Jørgensen, Morten Egevang Jørgensen, Morten Egevang Jørgensen, Sophie Lambertz, Tobias Maierhofer, Zeinu Mussa Belew, Christoph Crocoll, Mohammed Saddik Motawia, Dietmar Geiger, Flemming Steen Jørgensen, Osman Mirza, Hussam Hassan Nour-Eldin   +13 more
doaj   +1 more source

MOM19, an import receptor for mitochondrial precursor proteins [PDF]

, 1989
We have identified a 19 kd protein of the mitochondrial outer membrane (MOM19). Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin ...
Söllner, Thomas, Pfaller, Rupert, Pfanner, Nikolaus, Neupert, Walter, Griffiths, Gareth   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ubiquitin initiates sorting of Golgi and plasma membrane proteins into the vacuolar degradation pathway

BMC Plant Biology, 2012
Background In yeast and mammals, many plasma membrane (PM) proteins destined for degradation are tagged with ubiquitin. These ubiquitinated proteins are internalized into clathrin-coated vesicles and are transported to early endosomal compartments. There,
Scheuring David, Künzl Fabian, Viotti Corrado, Yan Melody San Wan, Jiang Liwen, Schellmann Swen, Robinson David G, Pimpl Peter   +7 more
doaj   +1 more source

Characterization of granule-like structures in non-endocrine cells [PDF]

, 2006
All eukaryotic cells have transport pathways to constitutively secrete proteins. Endocrine, neuroendocrine, and exocrine cells in addition have a regulated secretory pathway that serves the controlled release of hormones, neuropeptides or digestive ...
Stettler, Hansruedi
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Types of Membrane Transporters and the Mechanisms of Interaction between Them and Reactive Oxygen Species in Plants

Antioxidants
Membrane transporters are proteins that mediate the entry and exit of substances through the plasma membrane and organellar membranes and are capable of recognizing and binding to specific substances, thereby facilitating substance transport.
Ding Yuan, Xiaolei Wu, Xiangqun Jiang, Binbin Gong, Hongbo Gao   +4 more
doaj   +1 more source

Outer membrane biogenesis in Helicobacter pylori: A deviation from the paradigm

Frontiers in Cellular and Infection Microbiology, 2012
The bacterial pathogen Helicobacter pylori is capable of colonizing the gastric mucosa of the human stomach using a variety of factors associated with or secreted from its outer membrane (OM).
George W. Liechti, Joanna B. Goldberg
doaj   +1 more source

Membrane Transport Proteins Expressed in the Renal Tubular Epithelial Cells of Seawater and Freshwater Teleost Fishes. [PDF]

Front Physiol, 2022
Kato A, Nagashima A, Hosono K, Romero MF.   +3 more
europepmc   +1 more source