Results 151 to 160 of about 2,949,634 (335)

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane

Journal of Extracellular Vesicles, 2017
Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin.
Kerstin Menck, Can Sönmezer, T. Worst, M. Schulz, G. H. Dihazi, F. Streit, G. Erdmann, Simon Kling, M. Boutros, C. Binder, J. Gross   +10 more
semanticscholar   +1 more source

Preparation of cell-derived vesicles from eukaryotic and prokaryotic origins for the delivery of biomolecules

Artificial Cells, Nanomedicine, and Biotechnology
Cell membrane-derived vesicles play essential roles in intercellular communication, material transport, and waste disposal. Despite their biomedical and industrial potential, isolating extracellular vesicles from natural sources remains technically ...
Jan Atienza-Garriga, Luke Smithers, Crystal Cooper, Alice Vrielink, Neus Ferrer-Miralles   +4 more
doaj   +1 more source

The Immunosuppressive Effect of Mesenchymal Stromal Cells on B Lymphocytes is Mediated by Membrane Vesicles

Cell Transplantation, 2013
The immunomodulatory properties of mesenchymal stromal cells are the subject of increasing interest and of widening clinical applications, but the reproducibility of their effects is controversial and the underlying mechanisms have not been fully ...
Manuela Budoni, Alessandra Fierabracci, Rosa Luciano, Stefania Petrini, Vincenzo Di Ciommo, Maurizio Muraca   +5 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Cholesterol re-organisation and lipid de-packing by arginine-rich cell penetrating peptides: Role in membrane translocation.

PLoS ONE, 2019
Cell penetrating peptides (CPPs) are able to transport hydrophilic molecules inside cells. To reach the cytosol, the peptide associated with a cargo must cross the plasma or the endosomal membrane.
Claudia Almeida, Ofelia Maniti, Margherita Di Pisa, Jean-Marie Swiecicki, Jesus Ayala-Sanmartin   +4 more
doaj   +1 more source

CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]

, 2017
Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie, Sirisaengtaksin, Natalie   +1 more
core   +1 more source

Force balance and membrane shedding at the Red Blood Cell surface

, 2006
During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nano-vesicles.
D. E. Discher, J. M. Werre, L. Backman, N. G. Van Kampen, Nir Gov, Pierre Sens, R. Bucki, R. E. Waugh, S. Levin, S.-C. Liu, S. P. Sutera, V. Bennett, W. H. Reinhart, Z. Tochner   +13 more
core   +1 more source

Extracellular vesicles: Exosomes, microvesicles, and friends

Journal of Cell Biology, 2013
Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively.
G. Raposo, W. Stoorvogel
semanticscholar   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles.

PLoS ONE, 2015
The platinum-based anticancer drug oxaliplatin is important clinically in cancer treatment. However, the role of multidrug resistance-associated protein 2 (MRP2) in controlling oxaliplatin membrane transport, in vivo handling, toxicity and therapeutic ...
Khine Myint, Yan Li, James Paxton, Mark McKeage   +3 more
doaj   +1 more source