Results 201 to 210 of about 322,454 (266)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

E-cigarette liquids alter the biogenesis and properties of <i>Aggregatibacter actinomycetemcomitans</i> outer membrane vesicles. [PDF]

Front Cell Infect Microbiol
Khodabakhsh Majd M, Wu LY, Cuadra GA, Brown AC.   +3 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Meropenem stress drives lipid remodeling and resistance gene dissemination via outer membrane vesicles in carbapenem-resistant <i>Klebsiella pneumoniae</i>. [PDF]

Curr Res Microb Sci
Fan F, Shi Q, Chen G, Zhan H, Deng S, Peng Y, Wei L.   +6 more
europepmc   +1 more source

Dual‐Mode Nanoporous SiO2 Memristors with Coexisting Volatile and Nonvolatile Dynamics for Reservoir Computing

Advanced Science, EarlyView.
A nanoporous SiO2 memristor enabling reconfigurable volatile and non‐volatile switching within a single device is demonstrated. The dual‐mode functionality supports both physical reservoir dynamics and synaptic weight storage, allowing unified hardware implementation of reservoir computing for temporal information processing, including image and ...
Bohao Ding, Tongjun Zhang, Li Shao, Nikolay Zhelev, Andrew L. Hector, Ruomeng Huang   +5 more
wiley   +1 more source

SARS-CoV-2 polyprotein expression and the induction of double-membrane vesicles. [PDF]

J Virol
Zhao M, Zhang Y, Liang Y, Lei F, Han Y, Yuan Z, Yi Z.   +6 more
europepmc   +1 more source

Chlamydial membrane vesicles deliver the beta barrel outer membrane protein OmpA to mitochondria to inhibit apoptosis. [PDF]

PLoS Pathog
Mesesan A, Oehler H, Kontchou CW, Haimovici A, Helmstädter M, Kretz O, Schilling O, Tholen S, Atanga J, Nazarenko I, Matti U, Ries J, Gentle IE, Häcker G.   +13 more
europepmc   +1 more source

Functional Cargo in Membrane Vesicles From a Citrus Pathogen. [PDF]

Environ Microbiol Rep
Araujo GG, Conforte MM, da Purificação AD, Todeschini I, Llontop EE, Angeli CB, Inague A, Yoshinaga MY, de Souza RF, Papai R, Luz MS, Miyamoto S, Palmisano G, Farah CS, Guzzo CR.   +14 more
europepmc   +1 more source

Deciphering macrophage molecular responses to <i>Porphyromonas gingivalis</i> outer membrane vesicles through combined immunoassay and Raman spectroscopic analyses. [PDF]

Front Microbiol
Matsuo Y, Son A, Gentile S, Bernola R, Yamashita T, Ikegami S, Sileo L, Ardondi L, Kariu T, Zavan B, Zhu W, Franceschini D, Bevilacqua E, Koutsikos K, Rigon L, Kamioka Y, Secci D, Pinton P, Pezzotti G.   +18 more
europepmc   +1 more source