Results 91 to 100 of about 18,395 (294)

Tacrolimus in membranous nephropathy [PDF]

Kidney International, 2008
To the Editor: In a recent issue of the Journal, Praga et al.1 reported their experience with tacrolimus monotherapy in patients with idiopathic membranous nephropathy. The authors concluded that tacrolimus was a very useful therapeutic option. This conclusion was based on the findings of a higher remission rate and a reduced risk of deterioration of ...
openaire   +2 more sources

Characterization of novel antigens in membranous nephropathy [PDF]

, 2016
INTRODUCTION: Membranous nephropathy is an autoimmune disease that targets glomeruli of the kidney. Previous discoveries in membranous nephropathy include the discovery of megalin as an antigen in the proximal tubular brush border fraction (Fx1A) and ...
Coles, Paige
core  

Table_1_Case Report: Membranous Nephropathy Secondary to Cobalamin C Disease.DOCX

, 2022
BackgroundMutation of MMACHC causes inherited cobalamin C disease with methylmalonic academia (MMA) and homocysteinemia. Renal complications may also be present in patients with this deficiency.
Zhao Hu (1308183), Zhaoli Gao (2835518), Yanxia Gao (614652), Qiang Wang (32383), Qi Wang (22418), Chenquan Tang (11981822)   +5 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Clinical, genetic and molecular aspects of membranous nephropathy

, 2011
Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
core  

Membranous nephropathy with rapid progression

Indian Journal of Nephrology, 2020
We report a 49-year-old man with microscopic hematuria, subnephrotic proteinuria, and rapidly progressive renal failure. His biopsy had features of PhosphoLipase A2 Receptor (PLA2R) positive membranous nephropathy with circumferential cellular crescents. Further work-up revealed IgG antiGlomerular Basement Membrane (anti-GBM) antibody titer of 188 U/mL
Vairakkani, R., Valavan, K. Thirumal, Fernando, M. Edwin, Raj, T. Yashwanth   +3 more
openaire   +2 more sources

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy

, 2017
G.L. and P.R. contributed equally to this work.International audienceThe phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous nephropathy.
Pierre Ronco, Zaghrini, Christelle, Vincent L.M. Esnault, Ronco, Pierre, Barbara Seitz-Polski, Hanna Debiec, Alexandra Rousseau, Karine Dahan, Payre, Christine, Esnault, Vincent L.M., Seitz-Polski, Barbara, Dahan, Karine, Rousseau, Alexandra, Gérard Lambeau, Christine Payré, Debiec, Hanna, Lambeau, Gérard, Christelle Zaghrini   +17 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

IgG4-related kidney disease (IgG4-RKD) with membranous nephropathy as its initial manifestation: report of one case and literature review

BMC Nephrology, 2019
Background IgG4-related disease (IgG4-RD) often affects multiple organs and tissues, especially the kidneys, and is characterized by interstitial nephritis, obstructive nephropathy, and in rare cases glomerulopathy (including membranous nephropathy ...
Nan-Nan Zhang, Yan-Yun Wang, Ling-Xin Kong, Wan-Zhong Zou, Bao Dong   +4 more
doaj   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted therapies remain ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source