Results 181 to 190 of about 105,016 (295)

Early‐stage 2K1C renovascular hypertension does not increase global MHC‐II or F4/80 abundance in the non‐clipped kidney but reveals focal F4/80+ induction

open access: yesExperimental Physiology, EarlyView.
Abstract The two‐kidney, one‐clip (2K1C) model produces renovascular hypertension. The effects on the clipped kidney (CK) are well described, while the non‐clipped kidney (NCK) is used as a model to evaluate the effects of high blood pressure. Although most of these effects have been described at later stages of 2K1C hypertension, it remains unclear ...
Pilar Cárdenas   +11 more
wiley   +1 more source

Antidiabetic Effect of Tiger Nut and Coconut Blend in Experimental Type 2 Diabetic Rat Model

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
The combination of tiger nut and coconut demonstrated antihyperglycemic, antihyperlipidemic, anti‐inflammatory, and antioxidant activities on type 2 diabetic rat model over a 4‐week treatment period. ABSTRACT Tiger nut and coconut are chewy and popularly consumed as food either alone, mixed, or paired with other fruits, seeds, and vegetables.
Aminu Mohammed, Mubarak Labaran Liman
wiley   +1 more source

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Semaphorin 3B-Membranous Nephropathy in Adults. [PDF]

open access: yesKidney Int Rep
Arevalo Salazar D   +4 more
europepmc   +1 more source

Development and Validation of Two Analytical Methods Using High‐Performance Liquid Chromatography and Atomic Absorption Spectroscopy for the Analysis of Tunisian Marketed Pharmaceutical Product‐Based Insulin and Zinc: Application in Routine Stability Study

open access: yesBiomedical Chromatography, Volume 40, Issue 11, November 2026.
ABSTRACT Given the widespread reliance on insulin among diabetic patients, ensuring its stability is an essential task not only for preserving its therapeutic efficacy but also for safeguarding patient health and safety. In addition, insulin storage practices were frequently misunderstood that may compromise drug potency.
Majdi Ben Messaoud   +7 more
wiley   +1 more source

Prenatal Diagnosis of Recurrent Fetal Intracranial Hemorrhage and a Maternally Inherited COL4A1 Variant of Uncertain Significance: A Case Report With Maternal Reverse Phenotyping

open access: yesClinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT A 33‐year‐old woman with two consecutive pregnancies affected by fetal left periventricular germinal matrix hemorrhage (Grade IV) and progressive ventriculomegaly underwent trio whole‐exome sequencing. A heterozygous COL4A1 c.4249G>C (p.Gly1417Arg) variant, classified as a variant of uncertain significance, was identified in the fetus of the ...
Wei Shi   +9 more
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus   +7 more
wiley   +1 more source

Designing the Data Elements for Patient Registry System for Membranous Nephropathy in Isfahan Province. [PDF]

open access: yesInt J Prev Med
Moeinzadeh F   +4 more
europepmc   +1 more source

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