Results 191 to 200 of about 105,016 (295)

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Critical Reappraisal of Obinutuzumab Randomized Trials in Membranous Nephropathy. [PDF]

Kidney Int Rep
Ruggenenti P, Trillini M, Podestà MA, Remuzzi G.   +3 more
europepmc   +1 more source

Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Narges Dastmalchi, Mohammad Amin Doustvandi, Reza Rahbarghazi, Khalil Hajiasgharzadeh   +3 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Clinical effect of obinutuzumab in the treatment of idiopathic membranous nephropathy. [PDF]

Am J Transl Res
Ning S, Zhang Q, Shang Z, Liu H.
europepmc   +1 more source

Occurrence and Risk Characterization of Ochratoxin A in Commercial Cow's Milk From Markazi Province, Iran

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
This study evaluated Ochratoxin A (OTA) contamination in 180 commercial milk samples from Markazi province, Iran. OTA was detected in 99.44% of samples, with raw milk exhibiting the highest levels. Health risk assessment revealed that Margin of Exposure (MOE) values for children consuming raw and pasteurized milk fell below safe thresholds, indicating ...
Pedram Hashemi, Mohammadhosein Movassaghghazani, Milica Zekovic   +2 more
wiley   +1 more source

Model-Informed Precision Dosing of Tacrolimus Initial Dosage Optimization in Membranous Nephropathy Patients. [PDF]

Drug Des Devel Ther
Cao P, Jin YW, Duan YY, Wang J, Ping ZH, Zhao SY, Du JY, He SM, Zhang HB, Wang DD.   +9 more
europepmc   +1 more source

Prohibitive Effects of ω‐3 on Pancreatic Damage in an Experimental Diabetes Model: Blood Glucose, Insulin, Lipid Profiles, Oxidative Stress, Inflammation, Pancreatic Tissue Morphology, and Apoptotic Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
These omega 3 and duration doses have been studied for the first time in the literature. At this dose and duration, omega 3 has shown very strong antioxidant, anti‐inflammatory and apoptotic effects. Omega‐3 can be used to alleviate diabetes and diabetes‐related complications. ABSTRACT This study aimed to investigate the potential protective effects of
Zeynep Erdemli, Mehmet Gul, Nurcan Gokturk, Fatma Ozhilal, Edanur Ozsoy, Harika Gozukara Bag, Mehmet Erman Erdemli   +6 more
wiley   +1 more source

Interpreting Rituximab Response in Seronegative Membranous Nephropathy [Letter]. [PDF]

Drug Des Devel Ther
Cao H, Hu L, Ma X.
europepmc   +1 more source

Acute kidney injury in a dog after ingestion of homemade modelling dough containing cream of tartar (potassium bitartrate)

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Summary A 16‐month‐old, male, neutered cocker spaniel developed gastrointestinal signs following ingestion of a homemade modelling dough containing cream of tartar. Blood biochemistry (29 hours post‐ingestion) showed elevated creatinine, urea and symmetric dimethylarginine (SDMA).
Fiona Adam, Nicola Bates
wiley   +1 more source