Results 31 to 40 of about 368,964 (263)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Le temple-mémorial de Château-Thierry : approche monographique
In Situ, 2005 The American memorial church of Château-Thierry, dedicated in 1924 has been built by two architects, Paul-Philippe Cret and Achille-Henri Chauquet. The church is adorned by a stained glass church window showing La Fayette welcoming Pershing and by some ...
Aline Magnien
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
In Situ, 2018 In 1997, the wreck of a World War Two bomber was unearthed near Fléville-devant-Nancy (Meurthe-et-Moselle). This archaeological excavation was a pioneering experience and some of its results were unexpected. The artefacts discovered during the excavation
Jean-Pierre Legendre
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Enfim chegando ao ponto de partida: Caminhos que me levaram ao ProfEPT
Metodologias e Aprendizado, 2021 Memorial acadêmico apresentado no Mestrado em Educaçâo Profissional e Tecnológica.
Denise Silva
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
In Memoriam: Dr. Hiroshi Hashimoto (1924–2015)
Journal of Limnology, 2018 Dr. Hiroshi Hashimoto, Emeritus Professor of Shizuoka University, passed away on 26th February 1915, at the age of 90. Chironomid workers within and beyond Japan must never forget that three entomologists, Drs Masaaki Tokunaga, Hiroshi Hashimoto and ...
Masaru Yamamoto
doaj +1 more source