Results 31 to 40 of about 992,394 (282)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reflections on the first Grounded Theory Seminar
Grounded Theory Review: An International Journal, 2022 I first met Dr. Barney Glaser in April 2002 in Paris, France the evening before the first CGT seminar. At that preliminary gathering I met Dr. Barry Gibson for the first time, who knew Barney.
Tom Andrews
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Le temple-mémorial de Château-Thierry : approche monographique
In Situ, 2005 The American memorial church of Château-Thierry, dedicated in 1924 has been built by two architects, Paul-Philippe Cret and Achille-Henri Chauquet. The church is adorned by a stained glass church window showing La Fayette welcoming Pershing and by some ...
Aline Magnien
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
In Situ, 2018 In 1997, the wreck of a World War Two bomber was unearthed near Fléville-devant-Nancy (Meurthe-et-Moselle). This archaeological excavation was a pioneering experience and some of its results were unexpected. The artefacts discovered during the excavation
Jean-Pierre Legendre
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
In Memoriam: Dr. Hiroshi Hashimoto (1924–2015)
Journal of Limnology, 2018 Dr. Hiroshi Hashimoto, Emeritus Professor of Shizuoka University, passed away on 26th February 1915, at the age of 90. Chironomid workers within and beyond Japan must never forget that three entomologists, Drs Masaaki Tokunaga, Hiroshi Hashimoto and ...
Masaru Yamamoto
doaj +1 more source
Enfim chegando ao ponto de partida: Caminhos que me levaram ao ProfEPT
Metodologias e Aprendizado, 2021 Memorial acadêmico apresentado no Mestrado em Educaçâo Profissional e Tecnológica.
Denise Silva
doaj +1 more source