Results 31 to 40 of about 385,015 (245)
Reflections on the first Grounded Theory Seminar
Grounded Theory Review: An International Journal, 2022 I first met Dr. Barney Glaser in April 2002 in Paris, France the evening before the first CGT seminar. At that preliminary gathering I met Dr. Barry Gibson for the first time, who knew Barney.
Tom Andrews
doaj
European Journal of Life Writing, 2020 This article considers Thomas Gray’s use of Lucretius’ De Rerum Natura in his prolific period of writing following Richard West’s death. Gray claims himself as ‘Master Tommy Lucretius’ in reference to his Latin philosophical poem, De Principiis Cogitandi;
James Morland
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Le temple-mémorial de Château-Thierry : approche monographique
In Situ, 2005 The American memorial church of Château-Thierry, dedicated in 1924 has been built by two architects, Paul-Philippe Cret and Achille-Henri Chauquet. The church is adorned by a stained glass church window showing La Fayette welcoming Pershing and by some ...
Aline Magnien
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
In Situ, 2018 In 1997, the wreck of a World War Two bomber was unearthed near Fléville-devant-Nancy (Meurthe-et-Moselle). This archaeological excavation was a pioneering experience and some of its results were unexpected. The artefacts discovered during the excavation
Jean-Pierre Legendre
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source