Results 41 to 50 of about 368,964 (263)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Approaching Religion, 2016 This paper discusses and analyses the memorial complex of Tsitsernakaberd in Yerevan as an architectural and symbolic entity in relation to Armenian national identity in the aftermath of the Armenian genocide of 1915.
Serafim Seppälä
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
La volonté politique de commémoration des morts appartient aux vivants
Conserveries Mémorielles, 2017 The monument materializes absence. This is a way to collectively share marks of the past revealing the political will of commemoration. Frequently referred to as the "duty of memory,” the understanding of what has been done and what can be done, do not ...
Audrey Rousseau
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
La cena del Señor a la luz de los diálogos luterano-católicos
Estudios Eclesiásticos, 2018 Con la celebración de los 50 años de diálogo entre católicos y luteranos, podemos empezar a establecer un balance que ofrece interesantes pistas doctrinales sobre la situación doctrinal de ambas confesiones. De las tres cuestiones sobre la eucaristía que
Pablo Blanco Sarto
doaj
Processos de constituição da docência: trajetórias de vida pessoal e profissional
Revista NUPEM, 2019 Nesta pesquisa interpretativa analisa-se o processo de constituição da docência de uma professora que atuou por 17 anos na Educação Básica, narrado em seu memorial de formação, tendo como fios condutores as trajetórias de sua vida pessoal, profissional e
Aline Maria de Medeiros Rodrigues Reali +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source