Results 41 to 50 of about 1,430,232 (305)

BMQ [PDF]

open access: yes, 1958
BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial ...
Bakst, Henry J.   +16 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Un exemple d’archéologie de l’aéronautique : la fouille de l’épave du bombardier de Fléville-devant-Nancy (Meurthe-et-Moselle)

open access: yesIn Situ, 2018
In 1997, the wreck of a World War Two bomber was unearthed near Fléville-devant-Nancy (Meurthe-et-Moselle). This archaeological excavation was a pioneering experience and some of its results were unexpected. The artefacts discovered during the excavation
Jean-Pierre Legendre
doaj   +1 more source

Working memory. [PDF]

open access: yesCurrent Biology, 1992
The term working memory refers to a brain system that provides temporary storage and manipulation of the information necessary for such complex cognitive tasks as language comprehension, learning, and reasoning. This definition has evolved from the concept of a unitary short-term memory system.
openaire   +4 more sources

Evans Medicine [PDF]

open access: yes, 1991
Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
Levinsky, Norman G.   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

In Memoriam: Dr. Hiroshi Hashimoto (1924–2015)

open access: yesJournal of Limnology, 2018
Dr. Hiroshi Hashimoto, Emeritus Professor of Shizuoka University, passed away on 26th February 1915, at the age of 90. Chironomid workers within and beyond Japan must never forget that three entomologists, Drs Masaaki Tokunaga, Hiroshi Hashimoto and ...
Masaru Yamamoto
doaj   +1 more source

Enfim chegando ao ponto de partida: Caminhos que me levaram ao ProfEPT

open access: yesMetodologias e Aprendizado, 2021
Memorial acadêmico apresentado no Mestrado em Educaçâo Profissional e Tecnológica.
Denise Silva
doaj   +1 more source

Audit report on the Iowa Centennial Memorial Foundation for the year ended May 31, 2008 [PDF]

open access: yes, 2008
Audit report on the Iowa Centennial Memorial Foundation for the year ended May 31 ...

core  

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