Results 41 to 50 of about 992,394 (282)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The 'Temple of Non-Being' at Tsitsernakaberd and remembrance of the Armenian genocide: an interpretation

Approaching Religion, 2016
This paper discusses and analyses the memor­ial complex of Tsitsernakaberd in Yerevan as an architectural and symbolic entity in relation to Armenian national identity in the aftermath of the Armenian genocide of 1915.
Serafim Seppälä
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

La volonté politique de commémoration des morts appartient aux vivants

Conserveries Mémorielles, 2017
The monument materializes absence. This is a way to collectively share marks of the past revealing the political will of commemoration. Frequently referred to as the "duty of memory,” the understanding of what has been done and what can be done, do not ...
Audrey Rousseau
doaj  

Processos de constituição da docência: trajetórias de vida pessoal e profissional

Revista NUPEM, 2019
Nesta pesquisa interpretativa analisa-se o processo de constituição da docência de uma professora que atuou por 17 anos na Educação Básica, narrado em seu memorial de formação, tendo como fios condutores as trajetórias de sua vida pessoal, profissional e
Aline Maria de Medeiros Rodrigues Reali, Ana Paula Gestoso de Souza, Eliana Marques Ribeiro Cruz   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

La cena del Señor a la luz de los diálogos luterano-católicos

Estudios Eclesiásticos, 2018
Con la celebración de los 50 años de diálogo entre católicos y luteranos, podemos empezar a establecer un balance que ofrece interesantes pistas doctrinales sobre la situación doctrinal de ambas confesiones. De las tres cuestiones sobre la eucaristía que
Pablo Blanco Sarto
doaj  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Le tourisme réflexif, un nouveau fondement d’un tourisme durable

Arbor: Ciencia, Pensamiento y Cultura, 2017
El desarrollo del turismo sostenible se enfrenta con la dificultad de utilizar un discurso contradictorio, y más en un contexto en el que se dan grandes concentraciones turísticas y en el que los flujos turísticos se intensifican de día en día.
Rémy Knafou
doaj   +1 more source