Results 41 to 50 of about 385,015 (245)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
In Memoriam: Dr. Hiroshi Hashimoto (1924–2015)
Journal of Limnology, 2018 Dr. Hiroshi Hashimoto, Emeritus Professor of Shizuoka University, passed away on 26th February 1915, at the age of 90. Chironomid workers within and beyond Japan must never forget that three entomologists, Drs Masaaki Tokunaga, Hiroshi Hashimoto and ...
Masaru Yamamoto
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
La volonté politique de commémoration des morts appartient aux vivants
Conserveries Mémorielles, 2017 The monument materializes absence. This is a way to collectively share marks of the past revealing the political will of commemoration. Frequently referred to as the "duty of memory,” the understanding of what has been done and what can be done, do not ...
Audrey Rousseau
doaj
Approaching Religion, 2016 This paper discusses and analyses the memorial complex of Tsitsernakaberd in Yerevan as an architectural and symbolic entity in relation to Armenian national identity in the aftermath of the Armenian genocide of 1915.
Serafim Seppälä
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
La cena del Señor a la luz de los diálogos luterano-católicos
Estudios Eclesiásticos, 2018 Con la celebración de los 50 años de diálogo entre católicos y luteranos, podemos empezar a establecer un balance que ofrece interesantes pistas doctrinales sobre la situación doctrinal de ambas confesiones. De las tres cuestiones sobre la eucaristía que
Pablo Blanco Sarto
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Processos de constituição da docência: trajetórias de vida pessoal e profissional
Revista NUPEM, 2019 Nesta pesquisa interpretativa analisa-se o processo de constituição da docência de uma professora que atuou por 17 anos na Educação Básica, narrado em seu memorial de formação, tendo como fios condutores as trajetórias de sua vida pessoal, profissional e
Aline Maria de Medeiros Rodrigues Reali +2 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source