Results 61 to 70 of about 486,459 (304)

Writing with Pictures: Immersive Technology and 21st Century Professional Development [PDF]

open access: yes, 2010
In The Language of New Media, Lev Manovich asks, “What kind of space is virtual space?” (254). This seemingly simple question will pose a number of challenges for writing centers as they develop services that transcend physical space. As writing center
Carpenter, Russell
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Hodonymy of Chengdu and Yekaterinburg: a Comparative Aspect

open access: yesНаучный диалог, 2020
The nominative types and models of the hodonyms of Chengdu and Yekaterinburg is compared in the article, the task of finding universals in the hodonymy is set.
E. E. Ivanova, Ling Lan
doaj   +1 more source

Excavaciones arqueológicas y el entorno urbano de Berlín : recordar y olvidar la huellas de la Segunda Guerra Mundial [PDF]

open access: yes, 2018
This essay examines how the Second World War can be remembered through archeology at two tourism sites in Berlin. Through data collected from site visits and observations, the motifs of burial, authenticity, and historical value are found to engage ...
Florence, Eloise
core  

The Dr Elizabeth Casson Memorial Lecture 2018: Occupational stories from a global city [PDF]

open access: yes, 2018
The Dr Elizabeth Casson Memorial Lecture 2018, given on June 12th 2018 at the 42nd Annual Conference and Exhibition of the Royal College of Occupational Therapists, held at the Belfast Waterfront, Belfast, UK.
Pollard, Nicholas
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Юзовка – Сталино – Донецк: политизация национального вопроса в прозе о Донбассе советских писателей 1930–1980-х гг.

open access: yesStudia Rossica Posnaniensia
Donetsk is a young industrial city. This is captured in the history of its naming, reflective of the transformations of the politics of the two empires: Yuzovka – Stalino – Donetsk.
Eleonora Shestakova
doaj   +1 more source

Memento Mori : Memento Maori – moko and memory [PDF]

open access: yes, 2009
Moko patterns, mau moko, “wearing ink” is often explained as an act of remembrance, a symbol of honour or success, of grieving or loss. Memento mori, remembering the dead and remembrance of death, pervades the Maori world, and is profoundly expressed in ...
Te Awekotuku, Ngahuia
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Mount Rushmore: A Tomb for Dead Ideas of American Greatness [PDF]

open access: yes, 2015
The Mount Rushmore National Memorial stands in the Black Hills of South Dakota as a symbol of American greatness. However, the public perceptions of the greatness represented in this memorial do not take into consideration the ideals held by the three ...
Rollins, Caleb
core   +1 more source

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