Results 71 to 80 of about 5,619,365 (290)

Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease

Alzheimer’s Research & Therapy
Background With the approval of disease-modifying treatments (DMTs) for early Alzheimer’s disease (AD), there is an increased need for efficient and non-invasive detection methods for cerebral amyloid-β (Aβ) pathology. Current methods, including positron
Matthew D. Howe, Karysa J. Britton, Hannah E. Joyce, William Menard, Sheina Emrani, Zachary J. Kunicki, Melanie A. Faust, Brittany C. Dawson, Meghan C. Riddle, Edward D. Huey, Shorena Janelidze, Oskar Hansson, Stephen P. Salloway   +12 more
doaj   +1 more source

Reactions to learning a “not elevated” amyloid PET result in a preclinical Alzheimer’s disease trial

Alzheimer’s Research & Therapy, 2018
Background The experiences of biomarker-ineligible cognitively normal persons can inform trial conduct and the translation of preclinical Alzheimer’s disease (AD) into clinical practice.
Joshua D. Grill, Chelsea G. Cox, Kristin Harkins, Jason Karlawish   +3 more
doaj   +1 more source

Existence Results for Some Damped Second-Order Volterra Integro-Differential Equations [PDF]

, 2014
In this paper we make a subtle use of operator theory techniques and the well-known Schauder fixed-point principle to establish the existence of pseudo-almost automorphic solutions to some second-order damped integro-differential equations with pseudo ...
In Memory, Ould Hamidoune, Prof Yahya, Toka Diagana   +3 more
core  

Population-based incremental learning with memory scheme for changing environments [PDF]

, 2005
Copyright @ 2005 ACMIn recent years there has been a growing interest in studying evolutionary algorithms for dynamic optimization problems due to its importance in real world applications.
Yang, S
core   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

The RUB cage: Respiration-Ultrasonic vocalizations-Behavior acquisition set-up for assessing emotional memory in rats

Frontiers in Behavioral Neuroscience, 2011
In animals, emotional memory is classically assessed through pavlovian fear conditioning in which a neutral novel stimulus (conditioned stimulus) is paired with an aversive unconditioned stimulus.
Chloe eHegoburu, Chloe eHegoburu, Kiseko eShionoya, Kiseko eShionoya, Samuel eGarcia, Samuel eGarcia, Belkacem eMessaoudi, Belkacem eMessaoudi, Marc eThevenet, Marc eThevenet, Anne-Marie eMouly, Anne-Marie eMouly   +11 more
doaj   +1 more source

The age-related effect on cognitive performance in cognitively healthy elderly is mainly caused by underlying AD pathology or cerebrovascular lesions: implications for cutoffs regarding cognitive impairment

Alzheimer’s Research & Therapy, 2020
Background As research in treatments for neurocognitive diseases progresses, there is an increasing need to identify cognitive decline in the earliest stages of disease for initiation of treatment in addition to determining the efficacy of treatment. For
Emma Borland, Erik Stomrud, Danielle van Westen, Oskar Hansson, Sebastian Palmqvist   +4 more
doaj   +1 more source

Glucose enhancement of memory is modulated by trait anxiety in healthy adolescent males [PDF]

, 2011
Glucose administration is associated with memory enhancement in healthy young individuals under conditions of divided attention at encoding. While the specific neurocognitive mechanisms underlying this ‘glucose memory facilitation effect’ are currently ...
Chiron C, Craft S, Delis DC, Gold PE, Hilary L Hii, JAM van Eekelen, Jonathan K Foster, Kaplan RJ, Michael A Smith, Parent MB, Pettersen JA, Plat L, Riby LM, Spielberger CD, Strauss E   +14 more
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Vertical Surrounding Gate Transistor for High Density and Low Voltage Operation in DRAM

IEEE Access
In this article, a honeycomb vertical surrounding gate access transistor array scheme is proposed to further decrease the DRAM cell area with aggressively shrink bit line (BL) pitch and word line (WL) pitch adopting the ZigZag BL and WL air gap.
Wenqi Wang, Sang Don Yi, Fu Li, Qingchen Cao, Jiangliu Shi, Bok-Moon Kang, Meichen Jin, Chang Liu, Zhenhua Wu, Guilei Wang, Chao Zhao   +10 more
doaj   +1 more source