Results 1 to 10 of about 945,021 (335)

Memory disorders in children [PDF]

, 2013
Memory disorders are a frequent consequence of a variety of childhood neurological conditions. We will review the characteristics of memory disorders as a function of the main four memory systems: short-term memory, episodic memory, semantic memory, and procedural memory.
Majerus, Steve, Van der Linden, Martial
openaire   +4 more sources

The financial consequences of undiagnosed memory disorders. [PDF]

J financ econ
Gresenz CR, Mitchell JM, Rodriguez B, Wang C, Turner RS, van der Klaauw W.   +5 more
europepmc   +2 more sources

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

Nature Communications, 2021
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla   +34 more
doaj   +1 more source

Grey and white matter correlates of recent and remote autobiographical memory retrieval:Insights from the dementias [PDF]

, 2014
The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more ...
A Barnabe, A Gilboa, A Gilboa, A Mechelli, A Viard, A Viard, AE Cavanna, B Levine, Bonnie Y. K. Lam, BYK Lam, CM Kipps, D Rueckert, DL Greenberg, DL Greenberg, DR Addis, E Mioshi, E Mioshi, E Svoboda, EA Maguire, EA Maguire, EA Maguire, G Northoff, G Winocur, GB Karas, GM McKhann, H Söderlund, HE Moss, HJ Rosen, HJ Rosen, HM Bonnici, J Ashburner, J Greene, J Morris, John R. Hodges, JR Binder, JR Hodges, K Oishi, K Rascovsky, L Nadel, L Squire, Laurie Miller, M Irish, M Irish, M Irish, M Irish, M Irish, M Irish, M Irish, M McKinnon, M Mion, M Moscovitch, M Piefke, M Sollberger, M Sugiura, M Visser, MA Conway, MA Conway, Michael Hornberger, ML Gorno-Tempini, Muireann Irish, N Philippi, O Meulenbroek, Olivier Piguet, P Piolino, P Piolino, P Piolino, P Piolino, R Cabeza, R Reitan, R Westmacott, Ramon Trullas, RS Rosenbaum, S Mori, S Oddo, S Savage, S Sheldon, S Steinvorth, Shadi El Wahsh, Sharpley Hsieh, SM Smith, SM Smith, SM Smith, Suncica Lah, TC Chua, TE Nichols, V Matuszewski, Y Zhang   +86 more
core   +6 more sources

Reasons for undergoing amyloid imaging among cognitively unimpaired older adults

Annals of Clinical and Translational Neurology, 2021
Objectives Preclinical Alzheimer’s disease (AD) clinical trials screen cognitively unimpaired older adults for biomarker criteria and disclose their results.
Mary M. Ryan, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source

Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials

Alzheimer’s Research & Therapy, 2023
Background Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample size calculations. Alzheimer’s disease (AD) is an area of active treatment development.
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source

Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials

Alzheimer’s Research & Therapy, 2023
Background Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials successfully answer the scientific questions under study.
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source

Microglial APOE4: more is less and less is more

Molecular Neurodegeneration, 2023
Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer’s disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear.
Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jones   +1 more
doaj   +1 more source

Temporally Graded Activation of Neocortical Regions in Response to Memories of Different Ages [PDF]

, 2007
The temporally graded memory impairment seen in many neurobehavioral disorders implies different neuroanatomical pathways and/or cognitive mechanisms involved in storage and retrieval of memories of different ages.
Antuono, Piero, Douville, Kelli, Franczak, Malgorzata, Miller, Sarah K., Nielson, Kristy A., Rao, Stephen M., Seidenberg, Michael, Woodard, John L.   +7 more
core   +2 more sources

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

Journal of Neuroinflammation, 2018
Background Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer’s disease.
Liqi Tong, G. Aleph Prieto, Carl W. Cotman   +2 more
doaj   +1 more source