Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction We sought to examine the association of race/ethnicity with willingness to engage in studies that involve procedures typical of Alzheimer's disease (AD) clinical trials and determine whether any observed differences could be explained by ...
Christian R. Salazar +3 more
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Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin
Methods and Protocols, 2020 Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insulin ...
Caitlin N. Suire +2 more
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Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
Scientific Data, 2021 Measurement(s) Protein Expression • gene expression • electrophysiology data • protein measurement • behavior Technology Type(s) immunofluorescence microscopy assay • RNA sequencing • electrophysiology assay • Electrochemiluminescence Immunoassay ...
Stefania Forner +20 more
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From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders [PDF]
, 2016 Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally,
Di Bonaventura, Maria Vittoria Micioni +3 more
core +2 more sources
Potential health effects of Champagne wine consumption [PDF]
, 2011 Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of cardiovascular and neurodegenerative disorders.
Corona, Giulia +7 more
core +1 more source
Overgeneral past and future thinking in dysphoria: the role of emotional cues and cueing methodology [PDF]
, 2015 Overgeneral memory, where individuals exhibit difficulties in retrieving specific episodes from autobiographical memory, has been consistently linked with emotional disorders. However, the majority of this literature has relied upon a single methodology,
Anderson, Rachel J. +2 more
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Protocol for single-nucleus ATAC sequencing and bioinformatic analysis in frozen human brain tissue
STAR Protocols, 2022 Summary: Single-nucleus ATAC sequencing (snATAC-seq) employs a hyperactive Tn5 transposase to gain precise information about the cis-regulatory elements in specific cell types. However, the standard protocol of snATAC-seq is not optimized for all tissues,
Zechuan Shi +4 more
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The history of written language disorders: reexamining Pitres’ case (1884) of pure agraphia [PDF]
, 2003 The first clinical description of pure agraphia was reported by the French neurologist Pitres in 1884. Pitres used the case study evidence to argue for modality-specific memory representations and the localization of writing.
Aimard +66 more
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Modulation of adult-born neurons in the inflamed hippocampus. [PDF]
, 2013 Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core +2 more sources
Communicating mild cognitive impairment diagnoses with and without amyloid imaging
Alzheimer’s Research & Therapy, 2017 Background Mild cognitive impairment (MCI) has an uncertain etiology and prognosis and may be challenging for clinicians to discuss with patients and families.
Joshua D. Grill +17 more
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