Results 81 to 90 of about 11,896,249 (305)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of cyclopentane addition on increasing the energy storage density in a CO2 hydrate power generation system

Nihon Kikai Gakkai ronbunshu, 2020
In this study, we clarify the effect of cyclopentane (CP), which is a formation reaction promoter and shifts the phase equilibrium curve to high temperature and low pressure, on the energy storage density of the proposed CO2 hydrate power generation ...
Masahito KAWAI, Shin’ya OBARA, Toshiaki KENCHI   +2 more
doaj   +1 more source

Congruency effects on recognition memory: A context effect.

Canadian Journal of Experimental Psychology / Revue canadienne de psychologie expérimentale, 2015
Two recent studies have reported that incongruent selective attention items are better remembered than congruent items on a surprise recognition memory test (Krebs, Boehler, De Belder, & Egner, 2013; Rosner, D’Angelo, MacLellan, & Milliken, 2014).
Milliken, Bruce, Rosner, Tamara, Rosner, Tamara   +2 more
openaire   +4 more sources

Effect of flunitrazepam on sleep and memory [PDF]

Psychiatry and Clinical Neurosciences, 1998
Flunitrazepam’s (FNZ) effect on sleep and memory 1 mg and 2 mg was investigated in 6 healthy volunteers (mean age 21.5 ± 0.8 years) by polysomnography (PSG) and memory testing. A PSG was recorded on each study night. Memory testing was done before sleep (40 min after taking FNZ or placebo), and after waking (560 min after medication).
K, Misaki, H, Nakagawa, Y, Koshino, H, Kishi, T, Ota, K, Okuda, I, Kanda, K, Isaki, T, Ito   +8 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On the spatial interaction of visual working memory and attention: Evidence for a global effect from memory-guided saccades [PDF]

, 2010
Herwig A, Beisert M, Schneider WX. On the spatial interaction of visual working memory and attention: Evidence for a global effect from memory-guided saccades. Journal of Vision.
M. Beisert, Beisert, M., W. X. Schneider, Beisert, Miriam, Schneider, W., Schneider, Werner X., Herwig, Arvid ; https://orcid.org/, A. Herwig, Herwig, A.   +8 more
core   +1 more source

Идентификация параметров математической α-модели переноса радона в накопительной камере по данным пункта Карымшина на Камчатке

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
Радон — инертный радиоактивный газ, исследования вариаций которого в сопоставлении с сейсмичностью считаются перспективными для целей разработки методик прогноза землетрясений.
Твёрдый, Д.А., Макаров, Е.О., Паровик, Р.И.   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Why do doctored images distort memory? [PDF]

, 2009
Doctored images can cause people to believe in and remember experiences that never occurred, yet the underlying mechanism(s) responsible are not well understood. How does compelling false evidence distort autobiographical memory?
Nash, Robert Alastair, Nash, Robert A., Rebecca J. Brewer, Brewer, RJ, Robert A. Nash, Kimberley A. Wade, Wade, Kimberley A., Nash, RA, Brewer, Rebecca J., Wade, KA   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source