Results 71 to 80 of about 2,605,266 (346)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Brain Sciences, 2021 In the present study, we investigated the effects of a four-week working memory (WM) and attention training program using commercial brain training (Synaptikon GmbH, Berlin). Sixty young healthy adults were assigned to the experimental and active control
Florian Scholl +2 more
doaj +1 more source
Effects of Transport Memory and Nonlinear Damping in a Generalized Fisher's Equation
, 2001 Memory effects in transport require, for their incorporation into reaction diffusion investigations, a generalization of traditional equations. The well-known Fisher's equation, which combines diffusion with a logistic nonlinearity, is generalized to ...
A. R. Bishop +22 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Temperature memory effect/triple-shape memory effect in niti shape memory alloys and shape memory effect in keratin [PDF]
, 2019 Besides the shape memory effect (SME), in which the permanent shape can be recovered at the presence of the right stimulus, the temperature memory effect (TME) is another feature of shape memory materials. The TME refers to a phenomenon that a particular temperature can be memorized in a certain manner.
openaire +2 more sources
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +6 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Itô equation model for dispersion of solutes in heterogeneous media
Journal of Numerical Analysis and Approximation Theory, 2008 Transport processes in heterogeneous media such as ionized plasmas, natural porous media, and turbulent atmosphere are often modeled as diffusion processes in random velocity fields. Using the Itô formalism, we decompose the second spatial moments of the
N. Suciu +4 more
doaj +2 more sources
How do individual cognitive differences relate to acceptability judgments?: A reply to Sprouse, Wagers, and Phillips [PDF]
, 2012 Sprouse, Wagers, and Phillips (2012) carried out two experiments in which they measured individual differences in memory to test processing accounts of island effects. They found that these individual differences failed to predict the magnitude of island
Casasanto, Laura Staum +2 more
core +1 more source