Results 51 to 60 of about 245,319 (256)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2018 The interplay of reinforcement learning and memory is at the core of several recent neural network models, such as the Attention-Gated MEmory Tagging (AuGMEnT) model.
Marco Martinolli +2 more
doaj +1 more source
Rapid acquisition of long spatial sequences in long-term memory [PDF]
, 2012 Learning complex movement sequences requires an active, attentional selection of the content that is learned. The selection mechanism can not be investigated in classical stimulus-guided sequence learning paradigms because it requires a movement sequence
Drever, Johannes
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Journal of Intelligence, 2023 There have been few studies on associations between age-related declines in fluid cognition and functional ability in population-representative samples of middle-aged and older adults. We used a two-stage process (longitudinal factor analysis followed by
Elizabeth P. Handing +2 more
doaj +1 more source
Transactional memory concurrency : new models and systems [PDF]
, 2009 textTransactional memory (TM) aims to bring the benefits of ACID transactions to the volatile world of program synchronization. Architectural trends are making software transactions more appealing, as more programmers struggle with the problems of locks ...
Ramadan, Hany E.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Is there a relation between working memory limitation and sentence comprehension? A study of conduction and agrammatic aphasia [PDF]
, 2006 The study explored the nature of the relation between phonological working memory and sentence comprehension in conduction and agrammatic aphasia. We compared two types of processing required during sentence comprehension: syntactic-semantic and word ...
Friedmann, Naama, Gvion, Aviah
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