Results 61 to 70 of about 245,319 (256)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Limitations of Human Visual Working Memory [PDF]
, 2004 The present empirical study investigates limitations of human visual working memory (VWM). The experiments of the present work involve the experimental paradigm of change detection using simple geometrical objects in the form of rectangles of different ...
Wesenick, Maria-Barbara
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Frontiers in Psychology, 2017 While some first language (L1) reading models suggest that inefficient word recognition and small working memory tend to inhibit higher-level comprehension processes; the Compensatory Encoding Model maintains that slow word recognition and small working ...
Feifei Han
doaj +1 more source
Attribute Memory Transfer Network for Unsupervised Cross-Domain Person Re-Identification
IEEE Access, 2020 Person re-identification (re-ID) presents various applications in surveillance system, but most existing models are proposed under supervised framework. These methods require large amounts of annotated pedestrian data, which limits their scalability and ...
Xiaochen Zheng +5 more
doaj +1 more source
Proposal for space-borne quantum memories for global quantum networking
npj Quantum Information, 2021 Global-scale quantum communication links will form the backbone of the quantum internet. However, exponential loss in optical fibres precludes any realistic application beyond few hundred kilometres.
Mustafa Gündoğan +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Adults' performance in an episodic-like memory task: The role of experience [PDF]
, 2019 Episodic memory is the ability to consciously recollect personal past events. This type of memory has been tested in non-human animals by using depletion paradigms that assess whether they can remember the "what," "where," and "when" (i.e., how long ago)
Atance, Cristina M, Martin-Ordas, Gema
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source