Results 51 to 60 of about 1,039,467 (200)

Redefining Memory T Cell Subsets [PDF]

Trends in Immunology, 2020
It has become increasingly clear that the terms used to define memory T cell subsets no longer accurately reflect our understanding of memory T cell biology. Here, we discuss the limitations of our current terminology and propose a new approach for defining memory T cell subsets.
Rod A, Rahimi, Andrew D, Luster
openaire   +2 more sources

Altered Endometrial Memory T-Cell Profiles During the Window of Implantation in Women with Previous Miscarriage

Biomedicines
Aim: This study aimed to characterize and compare the composition of central (TCM), effector (TEM), tissue-resident (TRM), and terminally differentiated (TEMRA) memory T cells in mid-luteal endometrium during the window of implantation (WOI) in women ...
Dimitar Parvanov, Rumiana Ganeva, Margarita Ruseva, Maria Handzhiyska, Jinahn Safir, Lachezar Jelezarsky, Dimitar Metodiev, Georgi Stamenov, Savina Hadjidekova   +8 more
doaj   +1 more source

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)

Медицинская иммунология, 2018
Memory T cells are necessary for development of the immune response and represent one of the most numerous population of human T lymphocytes. On the contrary, suppressive regulatory T cells (Tregs) may terminate the immune response and help to maintain ...
E. K. Oleinik, A. V. Churov, V. M. Oleinik   +2 more
doaj   +1 more source

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Cell Reports, 2020
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RBhi ...
Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford   +13 more
doaj   +1 more source

Superior T memory stem cell persistence supports long-lived T cell memory [PDF]

, 2013
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood.
David A. Price, Diane L. Bolton, Emma Gostick, Enrico Lugli, Genoveffa Franchini, Jason M. Brenchley, Kaimei Song, Luca Gattinoni, Maria H. Dominguez, Mario Roederer, Monica Vaccari, Nicholas P. Restifo, Nichole R. Klatt, O’Connor, Pratip K. Chattopadhyay, Roederer, Thomas A. Waldmann   +16 more
core   +1 more source

Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells

Frontiers in Immunology, 2018
Memory T-cells are essential to maintain long-term immunological memory. It is widely thought that the bone marrow (BM) plays an important role in the long-term maintenance of memory T-cells.
Mariona Baliu-Piqué, Myrddin W. Verheij, Julia Drylewicz, Lars Ravesloot, Lars Ravesloot, Rob J. de Boer, Ad Koets, Ad Koets, Kiki Tesselaar, José A. M. Borghans   +9 more
doaj   +1 more source

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +5 more sources

Plasticity of human CD4 T cell subsets

Frontiers in Immunology, 2014
Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of pathogen-specific T cells.
Jens eGeginat, Moira eParoni, Stefano eMaglie, Johanna Sophie Alfen, Ilko eKastirr, Paola eGruarin, Marco eDeSimone, Massimiliano ePagani, Sergio eAbrignani   +8 more
doaj   +1 more source

Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria in the mouse. [PDF]

PLoS ONE, 2010
Memory CD8(+) T cells represent an important effector arm of the immune response in maintaining long-lived protective immunity against viruses and some intracellular bacteria such as Listeria monocytogenes (L.m).
Marc Bajénoff, Emilie Narni-Mancinelli, Frédéric Brau, Grégoire Lauvau   +3 more
doaj   +1 more source