Results 31 to 40 of about 1,044,819 (294)

Distinct CD4−CD8− (Double-Negative) Memory T-Cell Subpopulations Are Associated With Indeterminate and Cardiac Clinical Forms of Chagas Disease

Frontiers in Immunology, 2021
CD4−CD8− (double-negative, DN) T cells are critical orchestrators of the cytokine network associated with the pathogenic inflammatory response in one of the deadliest cardiomyopathies known, Chagas heart disease, which is caused by Trypanosoma cruzi ...
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Carolina Cattoni Koh, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Maria do Carmo Pereira Nunes, Kenneth John Gollob, Kenneth John Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +10 more
doaj   +1 more source

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection [PDF]

, 2015
ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis.
Agata Stryjewska, Alexander Weidemann, Ananda W. Goldrath, Best, Bingfei Yu, Brabletz, Cannarile, Christiane Zweier, Conidi, Danny Huylebroeck, Engel, Eve Seuntjens, Garavelli, Gattinoni, Goldrath, Goossens, Goossens, Grégoire, Gründemann, Hand, Haring, Harney, Harney, Harty, Higashi, Higashi, Hikono, Hikono, Hisato Kondoh, J. Adam Best, Jessica V. Nguyen, Jody Haigh, Joshi, Kaech, Kaech, Kaech, Kaech, Kallies, Knell, Kyla D. Omilusik, Larabee, Lin, Luca Gattinoni, Lynne M. Bird, Massari, Masson, Mowat, Murre, Olson, Postigo, Postigo, Rahul Roychoudhuri, Remacle, Rice, Rubinstein, Sarkar, Sawada, Sekido, Seuntjens, Steven Goossens, Takemoto, Van de Putte, van den Berghe, van Grunsven, Verschueren, Verstappen, Voehringer, Williams, Wirth, Yang, Yasui, Yujiro Higashi, Zweier   +72 more
core   +3 more sources

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source

Memory T cells: strategies for optimizing tumor immunotherapy

Protein & Cell, 2020
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells ...
Qingjun Liu, Zhongjie Sun, Ligong Chen
doaj   +1 more source

CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]

, 1988
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments.
Jonjic, Stipan, Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J., Weiland, Frank   +4 more
core   +1 more source

Age related human T cell subset evolution and senescence

Immunity & Ageing, 2019
T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects.
Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li, Ling Xu   +8 more
doaj   +1 more source

Memory T Cells Discrepancies in COVID-19 Patients

Microorganisms, 2023
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected patients, with an ...
Hajir A. Al Saihati, Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Sabry Y. Mahmoud, Eman S. Farrag, Taha I. A. Mohamed, Samah M. Fathy, Mohamed E. Elnosary, Ali Sobhy, Abdelazeem E. Ahmed, Ahmed M. El-Adly, Fareed S. El-Shenawy, Asmaa A. Elsadek, Amal Rayan, Zeinab Albadry M. Zahran, Omnia El-Badawy, Mohamed G. M. El-Naggar, Magdy M. Afifi, Asmaa M. Zahran   +19 more
doaj   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Effector and memory CD4+ and CD8+ T cells in the chronic infection process.

Folia Histochemica et Cytobiologica, 2009
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate
Piotr Radziwon, Alina Lipska, Kamil Safiejko, Dominika Ojdana, Jacek Dadan, Elzbieta Tryniszewska   +5 more
doaj   +1 more source

C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection [PDF]

Open Biology, 2016
The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8+ T cells is controlled by costimulatory molecules, which modulates the development of memory ...
Mohammad Haque, Jianyong Song, Kristin Fino, Youfei Wang, Praneet Sandhu, Xinmeng Song, Christopher Norbury, Bing Ni, Deyu Fang, Shahram Salek-Ardakani, Jianxun Song   +10 more
doaj   +1 more source