Results 51 to 60 of about 1,044,819 (294)

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels [PDF]

, 2017
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to ...
Asquith, Asquith, Asquith, Beura, Bingaman, Bjorkdahl, Bonhoeffer, Borghans, Bruno, Chao, Choo, De Boer, De Boer, De Boer, De Boer, Debacq, Ganusov, Ganusov, Grossman, Hogan, Hogan, Hogan, Hogan, Homann, Kassiotis, Le Campion, Leignadier, Lenz, Macallan, Min, Mohri, Mohri, Nelson, Parretta, Pepper, Pitcher, Purton, Restifo, Ribeiro, Robertson, Seddon, Surh, Tough, Vezys, Vrisekoop, Westera, Yates, Younes   +47 more
core   +4 more sources

Redefining Memory T Cell Subsets [PDF]

Trends in Immunology, 2020
It has become increasingly clear that the terms used to define memory T cell subsets no longer accurately reflect our understanding of memory T cell biology. Here, we discuss the limitations of our current terminology and propose a new approach for defining memory T cell subsets.
Rod A, Rahimi, Andrew D, Luster
openaire   +2 more sources

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis

Brain Sciences, 2017
Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis.
Tanima Bose
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. [PDF]

, 2016
Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes.
Atkinson, Mark A, Brusko, Todd M, Gitelman, Stephen E, Gottlieb, Peter A, Haller, Michael J, Hulme, Maigan A, Mathews, Clayton E, Michels, Aaron W, Perry, Daniel J, Posgai, Amanda L, Schatz, Desmond A, Schultz, Andrew R, Shuster, Jonathan J, Wasserfall, Clive H, Zou, Baiming   +14 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)

Медицинская иммунология, 2018
Memory T cells are necessary for development of the immune response and represent one of the most numerous population of human T lymphocytes. On the contrary, suppressive regulatory T cells (Tregs) may terminate the immune response and help to maintain ...
E. K. Oleinik, A. V. Churov, V. M. Oleinik   +2 more
doaj   +1 more source

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Cell Reports, 2020
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RBhi ...
Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford   +13 more
doaj   +1 more source