Results 21 to 30 of about 1,044,819 (294)

T cell memory [PDF]

Seminars in Immunology, 2009
There is perhaps no more important function of the adaptive immune system than to confer protection from reinfection by pathogens previously encountered and defeated. Within the T cell lineage, this property of remembering past antigenic threats resides in the small subset of memory cells which persist long after the disappearance of the short-lived ...
openaire   +2 more sources

Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells.

PLoS ONE, 2015
CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important.
Eleonora Li Causi, Suraj C Parikh, Lindsey Chudley, David M Layfield, Christian H Ottensmeier, Freda K Stevenson, Gianfranco Di Genova   +6 more
doaj   +1 more source

Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting [PDF]

International Journal of Nutrition Sciences
Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion.
Sara Assadiasl, Narjes Soleimanifar, Mohammad Hassan Alamolhoda, Hanieh Mojtahedi, Maryam Sadr, Sepehr Safdel, Zahra Mozooni, Mohammad Hossein Nicknam   +7 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Journal of Hematology & Oncology, 2018
Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM
Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li   +11 more
doaj   +1 more source

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]

, 2017
The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian, Gordon, David E, Hull, Philip A, Jeng, Mark Y, Johnson, Jeffrey, Kasler, Herb, Krogan, Nevan, Kwon, Hye-Sook, Ng, Che-Ping, Ott, Melanie, Tsou, Chia-Lin, Verdin, Eric   +11 more
core   +1 more source

Memory T Cells in Flavivirus Vaccination

Vaccines, 2018
Flaviviruses include many medically important viruses, such as Dengue virus (DENV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV), West Nile (WNV), yellow fever (YFV), and Zika viruses (ZIKV).
Guangyu Li, Cody Teleki, Tian Wang
doaj   +1 more source

Metabolic features of naïve and memory CD4⁺T cells in quiescence and during proliferation

Acta Biomedica Scientifica, 2022
Background. Memory CD4+ T cells proliferation is the basis for accelerated secondary immune response. The characteristics of memory CD4+ T cells providing their faster division compared to naive CD4+ T lymphocytes are poorly understood.
V. V. Vlasova, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulations [PDF]

, 2015
CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Treg). FOXP3+ T cells are reported to be increased in tumour-bearing patients or animals, and considered to suppress ...
Fujii, H, Husson, F, Josse, J, Miyachi, Y, Ono, M, Tanioka, M   +5 more
core   +3 more sources

Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin α\(_4\)β\(_7\) [PDF]

, 2009
Background: The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 ...
Chakupurakal, Geothy, Cobbold, Mark, Mautner, Vivien, Moss, Paul AH, Onion, David   +4 more
core   +1 more source