Results 21 to 30 of about 429,538 (268)

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source

Memory T cells: strategies for optimizing tumor immunotherapy

Protein & Cell, 2020
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells ...
Qingjun Liu, Zhongjie Sun, Ligong Chen
doaj   +1 more source

Memory T Cell Migration [PDF]

Frontiers in Immunology, 2015
Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy.
Qianqian eZhang, Qianqian eZhang, Fadi G. Lakkis   +2 more
openaire   +3 more sources

Age related human T cell subset evolution and senescence

Immunity & Ageing, 2019
T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects.
Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li, Ling Xu   +8 more
doaj   +1 more source

C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection [PDF]

Open Biology, 2016
The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8+ T cells is controlled by costimulatory molecules, which modulates the development of memory ...
Mohammad Haque, Jianyong Song, Kristin Fino, Youfei Wang, Praneet Sandhu, Xinmeng Song, Christopher Norbury, Bing Ni, Deyu Fang, Shahram Salek-Ardakani, Jianxun Song   +10 more
doaj   +1 more source

SARS-CoV-2 reactive memory T cell immunity in healthy individuals

Zhongguo shuxue zazhi, 2022
Objective To understand the memory phenotype and function of SARS-CoV-2 reactive CD4+ T cells in healthy individuals. Methods In this study, SARS-CoV-2-derived peptides were used to stimulate PBMC from participants.SARS-CoV-2 reactive memory T cells were
Chen LUO, Yonghua YIN, Yudi XIE, Zhihang HE, Ling LI, Zhong LIU, Jue WANG, Qiang CHEN   +7 more
doaj   +1 more source

Effector and memory CD4+ and CD8+ T cells in the chronic infection process.

Folia Histochemica et Cytobiologica, 2009
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate
Piotr Radziwon, Alina Lipska, Kamil Safiejko, Dominika Ojdana, Jacek Dadan, Elzbieta Tryniszewska   +5 more
doaj   +1 more source

Memory T Cells Discrepancies in COVID-19 Patients

Microorganisms, 2023
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected patients, with an ...
Hajir A. Al Saihati, Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Sabry Y. Mahmoud, Eman S. Farrag, Taha I. A. Mohamed, Samah M. Fathy, Mohamed E. Elnosary, Ali Sobhy, Abdelazeem E. Ahmed, Ahmed M. El-Adly, Fareed S. El-Shenawy, Asmaa A. Elsadek, Amal Rayan, Zeinab Albadry M. Zahran, Omnia El-Badawy, Mohamed G. M. El-Naggar, Magdy M. Afifi, Asmaa M. Zahran   +19 more
doaj   +1 more source

The origins of memory T cells [PDF]

Nature, 2017
Memory T cells protect against previously encountered pathogens, but their origins are unclear. Two studies track DNA modifications over time and find that these cells arise from effector T cells. Memory T cells protect against previously encountered pathogens, but their origins are unclear.
Kyla D, Omilusik, Ananda W, Goldrath
openaire   +2 more sources

Memory T Cells

Biology of Blood and Marrow Transplantation, 2008
Memory. is the diary that we all carry about with us. Oscar Wilde, ‘‘The Importance of Being Earnest’’ And so it is with the immune system. Memory T cells are a critical component of the adaptive immune system. Our ability to respond rapidly to antigens/ pathogens that we have been exposed to previously is at the heart of the adaptive immune system. In
openaire   +2 more sources