Results 61 to 70 of about 1,039,467 (200)

Heterogeneity of memory T cells in aging

Frontiers in Immunology, 2023
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases.
Abhinav Jain, Ines Sturmlechner, Cornelia M. Weyand, Cornelia M. Weyand, Jörg J. Goronzy, Jörg J. Goronzy, Jörg J. Goronzy   +6 more
doaj   +1 more source

Th17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients [PDF]

, 2016
Background: Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory syndrome. While the involvement
Czesnikiewicz-Guzik, Marta, Jasiewicz-Honkisz, Barbara, Maciag, Joanna, Matusik, Pawel T., Mikolajczyk, Tomasz, Osmenda, Grzegorz, Sagan, Agnieszka, Schramm, Agata, Siedlinski, Mateusz, Sliwa, Tomasz, Wilk, Grzegorz   +10 more
core   +3 more sources

Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection.

PLoS ONE, 2020
Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection against secondary genital tract infection. While it is known that naïve antigen-specific CD4+ T cells can traffic to the genital tract in an antigen-specific ...
Jennifer D Helble, Alexander O Mann, Michael N Starnbach   +2 more
doaj   +1 more source

Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. [PDF]

PLoS Pathogens, 2017
Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined.
Nelson D Glennie, Susan W Volk, Phillip Scott   +2 more
doaj   +1 more source

Single-cell transcriptome profiling reveals enriched memory T-cell subpopulations in hypertension

Frontiers in Cell and Developmental Biology, 2023
Introduction: The adaptive immune response mediated by T cells plays a vital role in the initiation and maintenance of blood pressure (BP) elevation. Memory T cells, which are antigen-specific T cells, can respond specifically to repeated hypertensive ...
Xiaoqi Wang, Xiaobin Wu, Pei Zhang, Yuan Zhou, Jun Cai, Ling Jin, Ling Jin   +6 more
doaj   +1 more source

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +3 more sources

Futility Sustains Memory T Cells [PDF]

Immunity, 2014
Memory T cells display a distinct metabolic profile compared to effector T cells. In this issue of Immunity, O'Sullivan et al. (2014) report that memory T cells activate a "futile cycle" of de novo fatty-acid synthesis and concurrent fatty-acid oxidation to generate ATP for cell survival.
Weinberg, Samuel E., Chandel, Navdeep S.   +1 more
openaire   +2 more sources

Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

Frontiers in Immunology, 2021
Ataxia Telangiectasia (AT) is a rare inherited disorder characterized by progressive cerebellar ataxia, chromosomal instability, cancer susceptibility and immunodeficiency.
Thomas J. Weitering, Janine E. Melsen, Monique M. van Ostaijen-ten Dam, Corry M. R. Weemaes, Marco W. Schilham, Mirjam van der Burg   +5 more
doaj   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

Differential Cytokine Utilization and Tissue Tropism Results in Distinct Repopulation Kinetics of Naïve vs. Memory T Cells in Mice

Frontiers in Immunology, 2019
Naïve and memory T cells co-exist in the peripheral T cell pool, but the cellular mechanisms that maintain the balance and homeostasis of these two populations remain mostly unclear.
Hye Kyung Kim, Hyunsoo Chung, Juntae Kwon, Ehydel Castro, Christopher Johns, Nga V. Hawk, SuJin Hwang, Jung-Hyun Park, Ronald E. Gress   +8 more
doaj   +1 more source