Results 71 to 80 of about 1,039,467 (200)

Immunotherapeutic Potential of T Memory Stem Cells

Frontiers in Oncology, 2021
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM
Yujie Li, Dengqiang Wu, Xuejia Yang, Sufang Zhou, Sufang Zhou   +4 more
doaj   +1 more source

Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression [PDF]

, 2014
The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further ...
Cahn, Pedro, Falivene, Juliana, Gherardi, Maria Magdalena, Ghiglione, Yanina Alexandra, Giavedoni, Luis, Laufer, Natalia Lorna, Ruiz, Maria Julia, Salomon, Horacio Eduardo, Socías, María Eugenia, Sued, Omar Gustavo, Turk, Gabriela Julia Ana   +10 more
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Are human V\u3b42pos T cells really resistant to aging and Human Cytomegalovirus infection? [PDF]

, 2019
In their recent paper, Weili Xu et al. [1] described the different behaviors of V\u3b41pos and V\u3b42pos T cell subsets in response to lifelong stress and claimed that V\u3b42pos T cells are not affected by aging and Human Cytomegalovirus (HCMV ...
Dieli, F., Mavilio, D., Mikulak, J.
core   +2 more sources

Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells

JCI Insight, 2023
Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens.
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily DeFranco, Sandra Andorf, Tamara Tilburgs   +9 more
doaj   +1 more source

Central memory CD8+ T lymphocytes mediate lung allograft acceptance [PDF]

, 2014
Memory T lymphocytes are commonly viewed as a major barrier for long-term survival of organ allografts and are thought to accelerate rejection responses due to their rapid infiltration into allografts, low threshold for activation, and ability to produce
Alexander Sasha Krupnick, Andrew E. Gelman, Banuelos, Bernd H. Zinselmeyer, Cervera, Correale, Cypel, Daniel Kreisel, Ely, Gelman, Hollyce Hartzler, Iwakoshi, Jon H. Ritter, Kaech, Kaiser, Kelsey Toth, Konieczny, Lentsch, Mackey, Mark J. Miller, Masopust, Mikhail Y. Berezin, Myers, Nadazdin, Nozaki, Ryuiji Higashikubo, Sakaguchi, Shah, Sheridan, Sis, Steven T. Wang, Wan, Wenjun Li, Xue Lin, Yousem, Zhai, Ziegler   +36 more
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Tissue-Resident Memory T Cells [PDF]

Immunity, 2014
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance.
Schenkel, Jason M., Masopust, David
openaire   +2 more sources

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

Journal for ImmunoTherapy of Cancer
Background Responsiveness to chimeric antigen receptor (CAR) T cell therapy correlates with CAR T cell expansion and persistence in vivo. Multiple strategies improve persistence by increasing stem-like properties or sustaining CAR T cell activity with ...
Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm   +9 more
doaj   +1 more source

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines

Cell Reports, 2018
Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A recently described subset of memory CD8+ T cells defined by intermediate expression of the chemokine receptor CX3CR1 was shown to have self-renewal ...
Claire Louse Gordon, Lian Ni Lee, Leo Swadling, Claire Hutchings, Madeleine Zinser, Andrew John Highton, Stefania Capone, Antonella Folgori, Eleanor Barnes, Paul Klenerman   +9 more
doaj   +1 more source

Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T cell Responses [PDF]

, 2012
Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in cellular responses. However, the effect of increased H2O2on an antigen-specific CD8+ T cell response was unknown.
A. E. Weant, Abate, Ahmed, Alexander-Miller, Barber, Blackburn, Case, Cayota, Chae, Chaudhri, Choi, Chung, Cui, D. G. Juneau, D.-Y. Yu, Das, Devadas, E. M. Hiltbold, E.-Y. Moon, Gopalakrishna, Grayson, Grayson, Hockenbery, Ichii, Imboden, Intlekofer, J. M. Grayson, Jabbari, Jonsson, Joshi, K. E. Crump, Kusmartsev, Kwon, L. B. Poole, Laniewski, Lee, Low, Matthews, May, Meng, Michalek, Moon, Murali-Krishna, Murali-Krishna, Mustelin, Nishi, Pearce, Perl, Piganelli, R. D. Michalek, Rutishauser, Shlomai, Tebo, Wherry, Wood, Wood, Xanthoudakis, Yang, Yang, Yi, Zenewicz, Zhang   +61 more
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In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo [PDF]

, 2018
Indexación: Scopus.Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist ...
Bono, M.R., Cruz, P., Cuadra, B., César Cárdenas, J., Fernández, D., Flores-Santibáñez, F., Gálvez-Cancino, F., Lladser, A., Núñez, S., Rosemblatt, M., Rosemblatt, M.V., Sauma, D.   +11 more
core   +2 more sources