Results 121 to 130 of about 1,249,343 (219)

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2–JAM3 tight junction structure and the blood–brain barrier integrity

Brain Pathology, EarlyView.
Pathogenic JAM2 mutations disrupt the JAM2–JAM3 heterodimer structure and tight junction integrity, leading to blood–brain barrier breakdown. Consequently, Jam2‐deficient mice develop prominent midbrain calcification and significant motor impairments, identifying the JAM2–JAM3 interaction as a vital target for primary brain calcification therapeutics ...
Dehao Yang, Lebo Wang, Chenxin Ying, Yihua Shi, Yuru Guo, Haotian Wang, Xinhui Chen, Yaoting Wang, Xinchen Wang, Fan Zhang, Xiaosheng Zheng, Yiling Chen, Haoyu Wang, Zhiru Lin, Jiaxiang Li, Haibin Xia, Jiawen Chen, Feng Fu, Bo Wang, Sheng Wu, Ping Wang, Fei Xie, Zhidong Cen, Zhiping Wang, Wei Luo   +24 more
wiley   +1 more source

Genomic dissection of divergent selection reveals a roadmap for reciprocal improvement of Chinese and American soybean

Journal of Integrative Plant Biology, EarlyView.
Genomic dissection of 2,377 soybean accessions identified 261 trait‐associated loci with distinct beneficial alleles in Chinese and American germplasms, enabled development of the Soybean Targeted Improvement Navigation System framework for targeted allele introgression, and provided genomic resources for knowledge‐driven soybean design breeding ...
Chengzhi Jiao, Delin Li, Hao Zhang, Zhongren Zhang, Xueqing Wang, Long Yan, Tianqing Zheng, Chaosen Zhao, Hongmei Qiu, Guangnan Xing, Guoyu Hu, Like Liu, Qiang Wang, Wen Huang, Xing Wang, Yumin Wang, Long Miao, YanFei Li, Xin Jing, Xiaojian Fang, Yu Tian, Ying‐Hui Li, Xiaobo Wang, Li‐Juan Qiu   +23 more
wiley   +1 more source

Gap‐Free Cannabis sativa Assemblies Reveal Post‐Polyploid Genome Remodelling and Refine the Evolution of Cannabinoid Synthase Genes

Plant Biotechnology Journal, EarlyView.
ABSTRACT Despite the therapeutic importance of cannabinoids, the scarcity of gap‐free Cannabis genomes has limited the dissection of the genetic and genomic basis of cannabinoid biosynthesis and genome evolution. Here, we generated two haplotype‐phased, gap‐free, gold‐standard assemblies and used them to investigate post‐polyploid genome remodelling ...
Jiangjiang Zhang, Chuchu Qin, Zhao Li, Lining Zhao, Ashok Biswas, Touming Liu, Mingbao Luan, Lin Li, Defang Li, Jianbin Yan   +9 more
wiley   +1 more source

Modeling and Implementation of Synchronization for Large-Aperture Electromagnetic MEMS Mirrors

Micromachines
MEMS-based LiDAR has showcased extensive application potential in the autonomous driving sector, attributed to its cost-effectiveness, compactness, and seamless integration capabilities.
Fahu Xu, Lingxiao Zhao
doaj   +1 more source

Multitask Diffractive Deep Neural Networks Enabled by Joint Distance–Frequency Encoding

Nanophotonics, Volume 15, Issue 21, 12 November 2026.
A joint distance–frequency encoding strategy enables a single passive diffractive neural network to switch among four computational tasks. By combining mechanically tunable layer spacing with a dual‐frequency phase‐independent metasurface, the same hardware performs orbital angular momentum classification, direction recognition, logic operations, and ...
Zhengxuan Jiang, Zongmao Fei, Wen Jiang, Guowen Ding, Ke Chen, Yijun Feng   +5 more
wiley   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Electrostatic MEMS Two-Dimensional Scanning Micromirrors Integrated with Piezoresistive Sensors

Micromachines
The MEMS scanning micromirror requires angle sensors to provide real-time angle feedback during operation, ensuring a stable and accurate deflection of the micromirror.
Yameng Shan, Lei Qian, Kaixuan He, Bo Chen, Kewei Wang, Wenchao Li, Wenjiang Shen   +6 more
doaj   +1 more source

Two-axis polydimethylsiloxane-based electromagnetic microelectromechanical system scanning mirror for optical coherence tomography

, 2018
Compact size and fast imaging abilities are key requirements for the clinical implementation of an optical coherence tomography (OCT) system. Among the various small-sized technology, a microelectromechanical system (MEMS) scanning mirror is widely used ...
Kim, J, Sehui Kim, Kim, JY, Lim, G, Changho Lee, Chulhong Kim   +5 more
core   +1 more source