Results 141 to 150 of about 236,698 (345)

Statistical methods for Mendelian randomization in genome-wide association studies: A review

Computational and Structural Biotechnology Journal, 2022
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
doaj  

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts. [PDF]

, 2019
It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene1. The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most ...
Ashley, Euan A, Balliu, Brunilda, Battle, Alexis, Bejerano, Gill, Bernstein, Jonathan A, Bonner, Devon, Boycott, Kym M, Care4Rare Canada Consortium, Davidson, Jean M, Davis, Joe R, Ferraro, Nicole M, Fisk, Dianna G, Frésard, Laure, Grove, Megan E, Hartley, Taila, Ingelsson, Erik, Joshi, Ruchi, Kernohan, Kristin D, Kohler, Jennefer N, Li, Xin, Lind, Lars, Liu, Boxiang, Marwaha, Shruti, Merker, Jason D, Montgomery, Stephen B, Prybol, Cameron J, Reuter, Chloe M, Smail, Craig, Smith, Kevin S, Strober, Benjamin J, Teran, Nicole A, Undiagnosed Diseases Network, Utiramerur, Sowmithri, Wheeler, Matthew T, Zappala, Zachary, Zastrow, Diane B   +35 more
core  

On certain characteristics of the Silk-worm which are apparently non-Mendelian [PDF]

, 1914
Keiko Toyama
openalex   +1 more source

Linked Mendelian Characters in a New Species of Drosophila [PDF]

, 1916
C. W. Metz
openalex   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

Partitioning of the genetic trends of French dairy sheep in Mendelian samplings and long-term contributions

Journal of Dairy Science, 2023
: The genetic trend of milk yield for 4 French dairy sheep breeds (Lacaune, Basco-Béarnaise, Manech Tête Noire, and Manech Tête Rousse) was partitioned in Mendelian sampling trends by categories of animals defined by sex and by selection pathways.
S. Antonios, A. Legarra, R. Pong-Wong, J.M. Astruc, S.T. Rodríguez-Ramilo, Z.G. Vitezica   +5 more
doaj  

Some properties of evolution algebras [PDF]

, 2013
The paper is devoted to the study of finite dimensional complex evolu- tion algebras. The class of evolution algebras isomorphic to evolution algebras with Jordan form matrices is described.
Camacho Santana, Luisa María, Gómez Martín, José Ramón, Omirov, Bakhrom Abdazovich, Turdibaev, R.M.   +3 more
core   +1 more source

A Mendelian Interpretation of Variation that is Apparently Continuous [PDF]

, 1910
E. M. East
openalex   +1 more source

Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir, Ronny Wickström, Anna Gunnerbeck, Stefanie Prast‐Nielsen, Nele Brusselaers   +4 more
wiley   +1 more source

Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data

Lipids in Health and Disease
Background Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging via Mendelian randomization methods.
Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang, Mengru Zhu   +6 more
doaj   +1 more source