Results 151 to 160 of about 236,698 (345)
Clinical Pharmacology &Therapeutics, EarlyView.Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost +9 more
wiley +1 more source
HeliyonThis study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan +9 more
doaj
Allium Vegetables Intake and Digestive System Cancer Risk: A Study Based on Mendelian Randomization, Network Pharmacology and Molecular Docking [PDF]
arXivBackground: Allium vegetables (garlic and onion) are one of the flavorings in people's daily diets. Observational studies suggest that intake of allium vegetables may be correlated with a lower incidence of digestive system cancers. However, the existence of a causal relationship is still controversial due to confounding factors and reverse causation ...
arxiv
Instrumental Variables Estimation with Some Invalid Instruments and its Application to Mendelian Randomization [PDF]
arXiv, 2014 Instrumental variables have been widely used for estimating the causal effect between exposure and outcome. Conventional estimation methods require complete knowledge about all the instruments' validity; a valid instrument must not have a direct effect on the outcome and not be related to unmeasured confounders.
arxiv
Developmental Dynamics, EarlyView.Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan +5 more
wiley +1 more source
Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseasePrecision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard‐of‐care for Mendelian cardiovascular disease (CVD).
Babken Asatryan +19 more
doaj +1 more source
Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates [PDF]
arXiv, 2018 Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of the exposure on the outcome. Complications arise with a binary exposure that is a dichotomization of
arxiv
Discovering new hub genes of dilated cardiomyopathy
ESC Heart Failure, EarlyView.Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu +9 more
wiley +1 more source