Results 141 to 150 of about 184,242 (260)

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Derivation for bidirectional Mendelian randomization model.

Derivation for bidirectional Mendelian randomization model.
Jinhao Zou (4853308), Rajesh Talluri (432994), Sanjay Shete (29012)   +2 more
core   +1 more source

Iqcm Is Dispensable for Male Fertility in Mice

iNew Medicine, EarlyView.
Schematic overview of the experimental workflow. Iqcm is highly expressed in mice testis (left). Iqcm−/− mice were generated via CRISPR/Cas9 (second panel). Phenotypic analyses including testis/epididymis histology (H&E), sperm morphology, and litter size revealed no significant differences between Iqcm+/+ and Iqcm−/− mice (third panel).
Zhaojuan Yu, Yuhui Ye, Mingfei Xiang, Zhaolian Wei, Zhen Lu, Jia Peng, Yunxia Cao   +6 more
wiley   +1 more source

Stroke and brain white/gray matter alterations: A Mendelian randomization investigation. [PDF]

Medicine (Baltimore)
Wu X, Yang L, Xu W, Guan H.
europepmc   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

Genetically predicted associations between inflammatory cytokines and juvenile idiopathic arthritis: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Pang J, Pan L, Liu P, Qin W, Yang J, Feng Y, He S, Yang S.   +7 more
europepmc   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

Lost in the System: The Labyrinth of Rare Disease Diagnosis

European Medical Journal
Peter Fish
doaj   +1 more source