Results 181 to 190 of about 314,978 (365)

Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits

International Journal of Cancer, EarlyView.
What's New? Hepatocellular carcinoma arises from a combination of environmental and genetic factors, with the latter playing a potentially more significant role in nonviral hepatocellular carcinoma. Here, the authors characterized the genetic correlations and heritability between nonviral hepatocellular carcinoma and 901 epidemiologic, behavioral, and ...
Younghun Han, Vikram R. Shaw, Jinyoung Byun, Aaron P. Thrift, Catherine Zhu, Donghui Li, Rikita I. Hatia, Robin Kate Kelley, Sean P. Cleary, Anna S. Lok, Paige M. Bracci, Jennifer B. Permuth, Roxana Bucur, Jennifer Knox, Jian‐Min Yuan, Amit G. Singal, Prasun K. Jalal, R. Mark Ghobrial, Yuko Kono, Dimpy P. Shah, Mindie H. Nguyen, Neehar D. Parikh, Richard Kim, Hui‐Chen Wu, Hashem El‐Serag, Ping Chang, Yun Shin Chun, Jian Gu, Chad Huff, Asif Rashid, Lu‐Yu Hwang, Alison P. Klein, Saira A. Khaderi, Ahmed O. Kaseb, Kathrine A. McGlynn, Lewis R. Roberts, Manal M. Hassan, Christopher I. Amos   +37 more
wiley   +1 more source

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

, 2016
Philip Haycock, Stephen Burgess, Kaitlin H. Wade, Jack Bowden, Caroline L. Relton, George Davey Smith   +5 more
openalex   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, EarlyView.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence

Journal of Adolescence, EarlyView.
ABSTRACT Purpose Pain, sleep disturbances, and substance use are common in adolescence, with research indicating that genetic and environmental factors account for variation in each of these behavioral and health outcomes. Moreover, pain, sleep disturbances, and substance use often co‐occur during adolescence. However, research has not examined whether
Kit K. Elam, Angel Trevino, Jodi Kutzner, Jinni Su, Patrick D. Quinn   +4 more
wiley   +1 more source

Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies

, 2019
Judith S. Brand, Romy Gaillard, Jane West, Rosemary McEachan, John Wright, Ellis Voerman, Janine F. Felix, Kate Tilling, Debbie A. Lawlor   +8 more
openalex   +1 more source

The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Bacterial and viral pathogens may play a key role in Behçet's disease (BD) pathogenesis by triggering autoimmunity, molecular mimicry, or microbiome disruption. These infectious agents could initiate inflammatory pathways, contributing to BD's diverse clinical manifestations.
Mohsen Moghoofei, Hamid Pajavand, Razieh Shahbazi, Marzieh Rezaei, Elahe Taki   +4 more
wiley   +1 more source

Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
Complex bidirectional causal relationships were found between gut microbiota abundance and Sjögren's syndrome (SS). Five circulating cytokines were shown to potentially affect SS, including MIG, IL‐5, IL‐1RA, IL‐2RA, and SCGF‐β, and SS was found to increase levels of two circulating cytokines, IL‐1β and IL‐5.
Yuchen Cai, Tianyi Zhou, Wenjun Shi, Xia Ding, Xueyao Cai, Li Yu   +5 more
wiley   +1 more source

Reduced Serum Soluble L‐Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
The study included 88 generalized anxiety disorder (GAD) patients and 88 age and sex‐matched healthy controls (HCs). A psychiatrist confirmed the GAD diagnosis, assessed symptom severity using the GAD‐7 scale, and evaluated controls based on the DSM‐5 criteria.
Farzana Akter Munny, Abir Hasan Pranto, Shimanta Paul, Md. Aminul Haque, Rashna Sharmin, Sharifa Sultana, Md. Alamgir Hossain, Md. Rabiul Islam   +7 more
wiley   +1 more source

Unifying framework explaining how parental regulatory divergence can drive gene expression in hybrids and allopolyploids

Nature Communications
Hybridization and polyploidy are powerful evolutionary forces, inducing a range of phenotypic outcomes, including non-additive expression, subgenome dominance, deviations in genomic dosage, and transcriptome downsizing. The reasons for these patterns and
Karel Janko, Jan Eisner, Petr Cigler, Tomáš Tichopád   +3 more
doaj   +1 more source