Results 181 to 190 of about 236,698 (345)
Exploration, EarlyView.The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe‐related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota ...
Changwu Wu +7 more
wiley +1 more source
Pedigree reconstruction for triploid apple cultivars using single nucleotide polymorphism array data
PLANTS, PEOPLE, PLANET, Volume 5, Issue 1, Page 98-111, January 2023., 2023 Many economically, culturally, and historically important apple cultivars are triploids, which have three copies of each chromosome instead of the more typical two copies in diploids. Despite their prevalence and importance, there have been conflicting reports regarding their origin and their ability to beget diploids.
Nicholas P. Howard +7 more
wiley +1 more source
Advanced Genetics, EarlyView.Here, causal relations are examined between 2940 plasma proteins and 19 cardiovascular diseases (CVD) using a human genetics‐based method. 218 proteins are found whose blood levels influence CVD risks, with about half being new discoveries and largely confirmed in an independent cohort.
Chen Li +13 more
wiley +1 more source
Frontiers in NutritionBackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing ...
Zhi-qiang Zhang +6 more
doaj +1 more source
The impact of coarsening an exposure on partial identifiability in instrumental variable settings [PDF]
arXivIn instrumental variable (IV) settings, such as in imperfect randomized trials and observational studies with Mendelian randomization, one may encounter a continuous exposure, the causal effect of which is not of true interest. Instead, scientific interest may lie in a coarsened version of this exposure.
arxiv
A New Gene Theory and an Explanation of the Phenomenon of Dominance to Mendelian Segregation of the Cytogene [PDF]
, 1946 Carl C. Lindegren
openalex +1 more source
MR.RGM: An R Package for Fitting Bayesian Multivariate Bidirectional Mendelian Randomization Networks [PDF]
arXivMotivation: Mendelian randomization (MR) infers causal relationships between exposures and outcomes using genetic variants as instrumental variables. Typically, MR considers only a pair of exposure and outcome at a time, limiting its capability of capturing the entire causal network.
arxiv
SAGE Open MedicineBackground: The association between smoking dependence and the risk of developing Barrett’s esophagus remains unclear. This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using ...
Zhou An, Meichun Zeng, Xianhua Wang
doaj +1 more source
Weak instruments in multivariable Mendelian randomization: methods and practice [PDF]
arXivThe method of multivariable Mendelian randomization uses genetic variants to instrument multiple exposures, to estimate the effect that a given exposure has on an outcome conditional on all other exposures included in a linear model. Unfortunately, the inclusion of every additional exposure makes a weak instruments problem more likely, because we ...
arxiv