Results 11 to 20 of about 133,969 (268)
Frontiers in Genetics, 2022 Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors.
Peng Shu +4 more
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Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study
Orphanet Journal of Rare Diseases, 2022 Introduction This study implemented MendelScan, a primary care rare disease case-finding tool, into a UK National Health Service population. Rare disease diagnosis is challenging due to disease complexity and low physician awareness.
Orlando Buendia +9 more
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Mendelian Randomization: Concepts and Scope [PDF]
Cold Spring Harbor Perspectives in Medicine, 2021 Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides a more robust understanding of the influence of these exposures on outcomes because germline ...
Richmond, Rebecca, Davey Smith, George
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Journal of Organization Design, 2023 AbstractIn his most recent book, Daniel Levinthal develops a theory of strategy and organization centred around a “Mendelian executive” who consciously seeks new strategic opportunities but is constrained by path dependence to search in spaces adjacent to the current state of affairs.
Marengo, L, Settepanella, S, Valente, M
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Nature Reviews Methods Primers, 2022 Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson +10 more
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Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
eLife, 2023 Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes.
Anatolie Marta +11 more
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Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding
Plants, 2023 Mendelian heredity is the cornerstone of plant breeding and has been used to develop new varieties of plants since the 19th century. However, there are several breeding cases, such as cytoplasmic inheritance, methylation, epigenetics, hybrid vigor, and ...
Mohsen Yoosefzadeh Najafabadi +2 more
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Mendelian and Non-Mendelian Quadratic Operators [PDF]
Applied Mathematics & Information Sciences, 2013 In this paper, we attempt to provide mathematical models of Mendelian and Non-Mendelian inheritances of the bisexual population system having Fisher's {\textbf{1:1}} principle. In our model, we always assume that distributions of the same phenotype of female and male populations are equal. We study the evolution of a Mendelian trait.
Ganikhodjaev, Nasir +2 more
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Monogenic Lupus: A Developing Paradigm of Disease
Frontiers in Immunology, 2018 Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients with a single gene defect. This rare variant of lupus generally presents with early onset severe disease, especially affecting the kidneys and central nervous system.
Jessie M. Alperin +3 more
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