Results 11 to 20 of about 184,242 (260)

Agricultural science, plant breeding and the emergence of a Mendelian system in Britain, 1880-1930 [PDF]

, 2011
Following Thomas P. Hughes’s systems approach in the history of technology, and making use of previously unexamined sources, this dissertation seeks to show that the development of British Mendelism may be explained, and the success it enjoyed more ...
Charnley, Berris
core   +6 more sources

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
core   +1 more source

Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases [PDF]

, 2011
Scientists have been trying to understand the molecular mechanisms of diseases to design preventive and therapeutic strategies for a long time. For some diseases, it has become evident that it is not enough to obtain a catalogue of the disease-related ...
Furlong, Laura I., Mayer, Miguel Ángel, 1960-, Mayer Miguel A., Sanz Ferran, Rautschka Michael, Sanz, Ferran, Bauer-Mehren Anna, Bundschus Markus, Laura I Furlong, Mayer, Miguel A., Furlong, Laura I., 1971-, Miguel A Mayer, Markus Bundschus, Laura I. Furlong, Ferran Sanz, Michael Rautschka, Rautschka, Michael, Miguel A. Mayer, Anna Bauer-Mehren, Bauer-Mehren, Anna, Furlong Laura I., Bundschus, Markus   +21 more
core   +1 more source

Correction: Mendelian and Non-Mendelian Regulation of Gene Expression in Maize [PDF]

, 2018
Correction: Mendelian and Non-Mendelian Regulation of Gene Expression in ...
Jianming Yu (102511), Jianming Yu, Gary J Muehlbauer, Lin Li (28817), Patrick S. Schnable, Patrick S. Schnable (102516), Lin Li, Marja C. P. Timmermans, Rena Shimizu, Kai Ying (102508), Michael J Scanlon, Katherine Petsch (102501), Michael J. Scanlon (102514), Sanzhen Liu, Gary J. Muehlbauer (76095), Marja C. P. Timmermans (102518), Katherine Petsch, Wayne Wenzhong Xu, Patrick S Schnable, Michael J. Scanlon, Gary J. Muehlbauer, Nathan M. Springer, Marja C P Timmermans, Rena Shimizu (102502), Kai Ying, Nathan M Springer, Sanzhen Liu (102504), Nathan M. Springer (102520), Wayne Wenzhong Xu (102506)   +28 more
core   +1 more source

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source

Response to mass selection when an identified major gene is segregating [PDF]

, 1998
A deterministic model to predict response with mass selection when a major locus is segregating is presented. The model uses a selection index framework in which the weight of the different components included in the index are adjusted to describe the ...
Ricardo Pong-Wong, Pong-Wong, R.; id_orcid, John A. Woolliams, Woolliams, John, John A Woolliams   +4 more
core   +1 more source

Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis

Biomedicines
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet severe immune-related adverse events (irAEs) often necessitate immunotherapy discontinuation and cause life-threatening complications.
Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li   +4 more
doaj   +1 more source

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

Emerging Themes in Epidemiology, 2009
Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried, Zhang Hongmei, Ogbuanu Ikechukwu U   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Evaluating algorithmic approaches to rare disease case-finding: a retrospective validation study using electronic health records

Orphanet Journal of Rare Diseases
Background Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of AI to routinely
Freya Boardman-Pretty, Jyothika Kumar, Calum Grant, Elena Marchini, William Evans, Lara Menzies, Rand Dubis, Amanda Worker, Elizabeth Varones, Alan Warren, Jack Sams, Daniel Ollerenshaw, Jez Stockdale, Hadley Mahon, Peter Fish   +14 more
doaj   +1 more source