Results 11 to 20 of about 164,706 (214)

Clarifying Mendelian vs non-Mendelian inheritance [PDF]

GENETICS
Abstract Gregor Mendel developed the principles of segregation and independent assortment in the mid-1800s based on his detailed analysis of several traits in pea plants. Those principles, now called Mendel's laws, in fact, explain the behavior of genes and alleles during meiosis and are now understood to underlie “Mendelian inheritance”
Susan Strome, Needhi Bhalla, Rohinton Kamakaka, Upasna Sharma, William Sullivan   +4 more
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Gene panel for Mendelian strokes [PDF]

Stroke and Vascular Neurology, 2020
Background Mendelian stroke causes nearly 7% of ischaemic strokes and is also an important aetiology of cryptogenic stroke. Identifying the genetic abnormalities in Mendelian strokes is important as it would facilitate therapeutic management and genetic ...
doaj   +2 more sources

Addressing the credibility crisis in Mendelian randomization [PDF]

BMC Medicine
Background Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyone who has ...
Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill   +4 more
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Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

Frontiers in Genetics, 2022
Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors.
Peng Shu, Lixian Ji, Zichuan Ping, Zhibo Sun, Wei Liu   +4 more
doaj   +1 more source

Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study

Orphanet Journal of Rare Diseases, 2022
Introduction This study implemented MendelScan, a primary care rare disease case-finding tool, into a UK National Health Service population. Rare disease diagnosis is challenging due to disease complexity and low physician awareness.
Orlando Buendia, Sneha Shankar, Hadley Mahon, Connor Toal, Lara Menzies, Pradeep Ravichandran, Jane Roper, Jag Takhar, Rudy Benfredj, Will Evans   +9 more
doaj   +1 more source

Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

eLife, 2023
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes.
Anatolie Marta, Tomáš Tichopád, Oldřich Bartoš, Jiří Klíma, Mujahid Ali Shah, Vendula Šlechtová Bohlen, Joerg Bohlen, Karel Halačka, Lukáš Choleva, Matthias Stöck, Dmitrij Dedukh, Karel Janko   +11 more
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Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding

Plants, 2023
Mendelian heredity is the cornerstone of plant breeding and has been used to develop new varieties of plants since the 19th century. However, there are several breeding cases, such as cytoplasmic inheritance, methylation, epigenetics, hybrid vigor, and ...
Mohsen Yoosefzadeh Najafabadi, Mohsen Hesami, Istvan Rajcan   +2 more
doaj   +1 more source

Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study : application to alcohol and cardiovascular traits [PDF]

, 2014
Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome.
Casas, Juan P., Leon, David A., Dudbridge, Frank, Whittaker, John C., Zuccolo, Luisa, Keating, Brendan J, Silverwood, Richard J., Holmes, Michael V, Smith, George Davey, Casas, Juan P, Silverwood, Richard J, Lawlor, Debbie A., Lawlor, Debbie A, Alcohol-ADH1B Consortium, Holmes, Michael V., Whittaker, John C, Leon, David A, Dale, Caroline E., Dale, Caroline E, Palmer, Tom M., Palmer, Tom, Keating, Brendan J.   +21 more
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Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
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Gene-disease network analysis reveals functional modules in mendelian, complex and environmental diseases [PDF]

, 2011
Scientists have been trying to understand the molecular mechanisms of diseases to design preventive and therapeutic strategies for a long time. For some diseases, it has become evident that it is not enough to obtain a catalogue of the disease-related ...
Furlong, Laura I., Mayer, Miguel Ángel, 1960-, Mayer Miguel A., Sanz Ferran, Rautschka Michael, Sanz, Ferran, Bauer-Mehren Anna, Bundschus Markus, Laura I Furlong, Mayer, Miguel A., Furlong, Laura I., 1971-, Miguel A Mayer, Markus Bundschus, Laura I. Furlong, Ferran Sanz, Michael Rautschka, Rautschka, Michael, Miguel A. Mayer, Anna Bauer-Mehren, Bauer-Mehren, Anna, Furlong Laura I., Bundschus, Markus   +21 more
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