Results 41 to 50 of about 178,874 (205)

Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis

Biomedicines
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet severe immune-related adverse events (irAEs) often necessitate immunotherapy discontinuation and cause life-threatening complications.
Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li   +4 more
doaj   +1 more source

Mendelian and Non-Mendelian Regulation of Gene Expression in Maize

PLoS Genetics, 2013
Transcriptome variation plays an important role in affecting the phenotype of an organism. However, an understanding of the underlying mechanisms regulating transcriptome variation in segregating populations is still largely unknown. We sought to assess and map variation in transcript abundance in maize shoot apices in the intermated B73 × Mo17 ...
Lin Li, Katherine Petsch, Rena Shimizu, Sanzhen Liu, Wayne Wenzhong Xu, Kai Ying, Jianming Yu, Michael J Scanlon, Patrick S Schnable, Marja C P Timmermans, Nathan M Springer, Gary J Muehlbauer   +11 more
openaire   +4 more sources

Prediction of genetic gain from quadratic optimisation with constrained rates of inbreeding [PDF]

, 2006
There are selection methods available that allow the optimisation of genetic contributions of selection candidates for maximising the rate of genetic gain while restricting the rate of inbreeding. These methods imply selection on quadratic indices as the
Avendano, S, John A. Woolliams, Woolliams John A, Avendaño Santiago, John A Woolliams, Villanueva Beatriz, Woolliams, JA, Villanueva, B., Beatriz Villanueva, Villanueva, B, Woolliams, John, Avenano, S., Santiago Avendaño   +12 more
core   +1 more source

Evaluating algorithmic approaches to rare disease case-finding: a retrospective validation study using electronic health records

Orphanet Journal of Rare Diseases
Background Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of AI to routinely
Freya Boardman-Pretty, Jyothika Kumar, Calum Grant, Elena Marchini, William Evans, Lara Menzies, Rand Dubis, Amanda Worker, Elizabeth Varones, Alan Warren, Jack Sams, Daniel Ollerenshaw, Jez Stockdale, Hadley Mahon, Peter Fish   +14 more
doaj   +1 more source

Equus in Online Mendelian Inheritance in Animals (OMIA)

Animals
Online Mendelian Inheritance in Animals (OMIA is a freely available information resource, which includes information for Equus inherited traits/diseases (collectively called phenes).
Imke Tammen, Ernest Bailey, Marius Mather, Frank W. Nicholas   +3 more
doaj   +1 more source

The Mendelian and Non-Mendelian Origins of Genetics [PDF]

, 2015
Mendel's paper as part of a large body of nineteenth-century literature on practical plant- and animal breeding and experimental hybridization, which contained a confusing and contradictory assortment of observations on heredity, some in line with Mendel’
Gliboff, Sander
core   +2 more sources

A machine learning algorithm for the detection of paroxysmal nocturnal haemoglobinuria (PNH) in UK primary care electronic health records

Orphanet Journal of Rare Diseases
Background Paroxysmal Nocturnal Haemoglobinuria (PNH) is an ultra-rare, acquired disorder that is challenging to diagnose due to varied symptoms, heterogeneous patient presentations, and lack of awareness among healthcare professionals.
Amanda Worker, Hadley Mahon, Jack Sams, Freya Boardman-Pretty, Elena Marchini, Rand Dubis, Alan Warren, Jez Stockdale, Jyothika Kumar, Elizabeth Varones, Daniel Ollerenshaw, Calum Grant, Peter Fish, Richard J. Kelly   +13 more
doaj   +1 more source

The Hidden Complexity of Mendelian Traits across Natural Yeast Populations

Cell Reports, 2016
Mendelian traits are considered to be at the lower end of the complexity spectrum of heritable phenotypes. However, more than a century after the rediscovery of Mendel’s law, the global landscape of monogenic variants, as well as their effects and ...
Jing Hou, Anastasie Sigwalt, Téo Fournier, David Pflieger, Jackson Peter, Jacky de Montigny, Maitreya J. Dunham, Joseph Schacherer   +7 more
doaj   +1 more source

Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study

Frontiers in Public Health, 2023
BackgroundObservational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding.
Tingting Wang, Qi Gao, Yuanyuan Yao, Ge Luo, Tao Lv, Guangxin Xu, Mingxia Liu, Jingpin Xu, Xuejie Li, Dawei Sun, Zhenzhen Cheng, Ying Wang, Chaomin Wu, Ruiyu Wang, Jingcheng Zou, Min Yan   +15 more
doaj   +1 more source

Causal effects of physical activity on the risk of overall ovarian cancer: A Mendelian randomization study

Digital Health, 2023
Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang, Huanling Zhao, Jiahao Zhu, Minmin Jiang   +3 more
doaj   +1 more source