Results 61 to 70 of about 164,706 (214)

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj   +1 more source

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

Nature Communications, 2021
Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and ...
Liza Darrous, Ninon Mounier, Zoltán Kutalik   +2 more
doaj   +1 more source

Genome and RNA sequencing boost neuromuscular diagnoses to 62% from 34% with exome sequencing alone

Annals of Clinical and Translational Neurology
Objective Most families with heritable neuromuscular disorders do not receive a molecular diagnosis. Here we evaluate diagnostic utility of exome, genome, RNA sequencing, and protein studies and provide evidence‐based recommendations for their ...
Rhett G. Marchant, Samantha J. Bryen, Melanie Bahlo, Anita Cairns, Katherine R. Chao, Alastair Corbett, Mark R. Davis, Vijay S. Ganesh, Roula Ghaoui, Kristi J. Jones, Andrew J. Kornberg, Monkol Lek, Christina Liang, Daniel G. MacArthur, Emily C. Oates, Anne O'Donnell‐Luria, Gina L. O'Grady, Ikeoluwa A. Osei‐Owusu, Haloom Rafehi, Stephen W. Reddel, Richard H. Roxburgh, Monique M. Ryan, Sarah A. Sandaradura, Liam W. Scott, Elise Valkanas, Ben Weisburd, Helen Young, Frances J. Evesson, Leigh B. Waddell, Sandra T. Cooper   +29 more
doaj   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm
G protein‐coupled receptors (GPCRs) are the largest and most diverse class of membrane proteins, mediating cellular responses to a wide range of extracellular stimuli.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
doaj   +1 more source

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

Correction: Mendelian and Non-Mendelian Regulation of Gene Expression in Maize [PDF]

, 2018
Correction: Mendelian and Non-Mendelian Regulation of Gene Expression in ...
Jianming Yu (102511), Jianming Yu, Gary J Muehlbauer, Lin Li (28817), Patrick S. Schnable, Patrick S. Schnable (102516), Lin Li, Marja C. P. Timmermans, Rena Shimizu, Kai Ying (102508), Michael J Scanlon, Katherine Petsch (102501), Michael J. Scanlon (102514), Sanzhen Liu, Gary J. Muehlbauer (76095), Marja C. P. Timmermans (102518), Katherine Petsch, Wayne Wenzhong Xu, Patrick S Schnable, Michael J. Scanlon, Gary J. Muehlbauer, Nathan M. Springer, Marja C P Timmermans, Rena Shimizu (102502), Kai Ying, Nathan M Springer, Sanzhen Liu (102504), Nathan M. Springer (102520), Wayne Wenzhong Xu (102506)   +28 more
core   +1 more source

The Spreading of Mendelian Characters [PDF]

Science, 1908
n ...
openaire   +3 more sources

MENDELSEEK: An algorithm that predicts mendelian genes and elucidates what makes them special.

PLoS Computational Biology
Although individual Mendelian diseases-those caused by a single gene-are rare, their collective disease burden is substantial. Identifying the causal gene for each condition is essential for accurate diagnosis and effective treatment.
Hongyi Zhou, Brice Edelman, Jeffrey Skolnick   +2 more
doaj   +1 more source

Association between Lp(a) and T2D: a Mendelian randomization study [PDF]

Introduction Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed.
Tadeusz Osadnik, Mateusz Lejawa, Jacek Jóźwiak, Marek Gierlotka, Marcin Goławski, Maciej Banach   +5 more
core   +1 more source

Mendelian randomization approach. [PDF]

, 2013
Mendelian randomization approach.
Akshay Anand (118579), Amod Gupta (118583), Suresh Kumar Sharma (118585), Sudesh Prabhakar (118584), Neel Kamal Sharma (118581), Ramandeep Singh (118586), Wei Chen (23863)   +6 more
core   +1 more source