Results 51 to 60 of about 164,706 (214)

Robust methods in Mendelian randomization [PDF]

, 2019
Mendelian randomization uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome using observational data.

core   +2 more sources

A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level

Communications Biology
The cellular and molecular mechanisms governing sexual reproduction are conserved across eukaryotes. Nevertheless, hybridization can disrupt these mechanisms, leading to asexual reproduction, often accompanied by polyploidy. In this study, we investigate
Dmitrij Dedukh, Anatolie Marta, Ra-Yeon Myung, Myeong-Hun Ko, Da-Song Choi, Yong-Jin Won, Karel Janko   +6 more
doaj   +1 more source

On Explaining Mendelian Phenomena [PDF]

Science, 1919
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openaire   +2 more sources

A Mendelian Character in Cattle [PDF]

Science, 1906
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openaire   +2 more sources

Identification and analyses of exonic and copy number variants in spastic paraplegia

Scientific Reports
Hereditary spastic paraplegias are a diverse group of degenerative disorders that are clinically categorized as isolated; with involvement of lower limb spasticity, or symptomatic, where spastic paraplegia is complicated by further neurological features.
Anum Shafique, Ayesha Nadeem, Faiza Aslam, Humera Manzoor, Muhammad Noman, Elizabeth Wohler, P. Dane Witmer, Nara Sobreira, Sadaf Naz   +8 more
doaj   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

The basic principles underlying Mendelian randomization. [PDF]

, 2021
Fig 1A is the three assumptions for Mendelian randomization analysis. Fig 1B is the basic principles of bi-directional Mendelian randomization. SNP is the single nucleotide polymorphism and IV is the instrumental variable.
Zhenxing Tu (11576846), Hongquan Chen (4056973), Zhiguang Liu (174159), Jie Ding (73711)   +3 more
core   +1 more source

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study [PDF]

ObjectiveVariation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA).
Pannoutsopoulou, K., Wheeler, M., Jones, G., Spector, T.D., Laslett, L.L., Cicuttini, F.M., Cooper, C., Metrustry, S., Zhang, W., Doherty, S., Arden, N.K., Doherty, M., Valdes, A.M., Zeggini, E., Maciewicz, R.A., Hart, D.J., Muir, K.R.   +16 more
core   +1 more source

The Mendelian Inheritance of Mutations [PDF]

Science, 1908
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openaire   +3 more sources

Human papilloma virus infection drives unique metabolic and immune profiles in head and neck and cervical cancers: implications for targeted therapies and prognostic markers

Discover Oncology
Human papillomavirus (HPV) is a key driver of head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESC). Yet, these cancers exhibit distinct molecular and clinical features influenced by HPV status. This study utilizes RNA
Saira Hamid, Mohd Shahnawaz Khan, Meraj Alam Khan, Naoshad Muhammad, Mayank Singh, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +7 more
doaj   +1 more source