Results 51 to 60 of about 178,874 (205)

Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers [PDF]

open access: yes, 2014
We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis.
Kumari, Meena   +449 more
core   +1 more source

Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies [PDF]

open access: yes, 2018
BACKGROUND—Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.
Mendelian Randomization of Dairy Consumption Working Group
core   +1 more source

Mechanisms of Mendelian dominance [PDF]

open access: yesClinical Genetics, 2017
Genetic dominance has long been considered as a qualitative reflection of interallelic interactions. Dominance arises from many multiple sources whose unifying theme is the existence of non‐linear relationships between the genotypic and phenotypic values.
R.A. Veitia, S. Caburet, J.A. Birchler
openaire   +2 more sources

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects [PDF]

open access: yes, 2011
Background Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism.
Craen, A.J.M.   +19 more
core   +1 more source

A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level

open access: yesCommunications Biology
The cellular and molecular mechanisms governing sexual reproduction are conserved across eukaryotes. Nevertheless, hybridization can disrupt these mechanisms, leading to asexual reproduction, often accompanied by polyploidy. In this study, we investigate
Dmitrij Dedukh   +6 more
doaj   +1 more source

Identification and analyses of exonic and copy number variants in spastic paraplegia

open access: yesScientific Reports
Hereditary spastic paraplegias are a diverse group of degenerative disorders that are clinically categorized as isolated; with involvement of lower limb spasticity, or symptomatic, where spastic paraplegia is complicated by further neurological features.
Anum Shafique   +8 more
doaj   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

open access: yesClinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan   +7 more
doaj   +1 more source

Human papilloma virus infection drives unique metabolic and immune profiles in head and neck and cervical cancers: implications for targeted therapies and prognostic markers

open access: yesDiscover Oncology
Human papillomavirus (HPV) is a key driver of head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESC). Yet, these cancers exhibit distinct molecular and clinical features influenced by HPV status. This study utilizes RNA
Saira Hamid   +7 more
doaj   +1 more source

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

open access: yesHeliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan   +9 more
doaj   +1 more source

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

open access: yesNature Communications, 2021
Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and ...
Liza Darrous   +2 more
doaj   +1 more source

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