Results 21 to 30 of about 164,706 (214)

Monogenic Lupus: A Developing Paradigm of Disease

Frontiers in Immunology, 2018
Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients with a single gene defect. This rare variant of lupus generally presents with early onset severe disease, especially affecting the kidneys and central nervous system.
Jessie M. Alperin, Lourdes Ortiz-Fernández, Amr H. Sawalha, Amr H. Sawalha   +3 more
doaj   +1 more source

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. [PDF]

, 2007
BACKGROUND: In conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than vice versa, may invalidate causal interpretations of ...
Timpson, NJ, Timpson, Nic, Harbord, RM, Day, Ian, Timpson Nic, Lawlor, D, Smith George Davey, Smith, George Davey, Lawlor, Debbie A, Ebrahim, S, Harbord, Roger, Day Ian, Debbie A Lawlor, Nic Timpson, George Davey Smith, Ian Day, Shah Ebrahim, Roger Harbord, Lawlor Debbie A, Day, INM, Davey Smith, G, Ebrahim, Shah, Harbord Roger, Ebrahim Shah   +23 more
core   +1 more source

Celer: an Efficient Program for Genotype Elimination [PDF]

Electronic Proceedings in Theoretical Computer Science, 2010
This paper presents an efficient program for checking Mendelian consistency in a pedigree. Since pedigrees may contain incomplete and/or erroneous information, geneticists need to pre-process them before performing linkage analysis.
Nicoletta De Francesco, Giuseppe Lettieri, Luca Martini   +2 more
doaj   +1 more source

Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea

ERJ Open Research, 2023
Background Based on evidence from existing observational research, clarifying the causal relationship between gastro-oesophageal reflux disease (GORD) and obstructive sleep apnoea (OSA) is challenging.
Gui Chen, Xin Gong, Shenrong Liu, Junyang Xie, Yingqi Wang, Wucheng Guo, Wenjing Liao, Lijuan Song, Xiaowen Zhang   +8 more
doaj   +1 more source

Coffee Consumption and Kidney Function: A Mendelian Randomization Study [PDF]

, 2019
Rationale & ObjectiveChronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment.
Wilson, James; id_orcid, Taal, Maarten W., Kennedy, Oliver J, Kennedy, Oliver John, Roderick, Paul J., Hayes, Peter C, Poole, Robin, Grzeszkowiak, Eryk Jan, Hayes, Peter, Roderick, Paul, Hayes, Peter C., Fallowfield, Jonathan A., Parkes, Julie, Fallowfield, Jonathan, Pirastu, Nicola, Grzeszkowiak, Eryk J., Kennedy, Oliver J., Wilson, James F.   +17 more
core   +2 more sources

IDENTIFYING CAUSAL GENETIC VARIANTS IN PSYCHIATRIC DISORDERS USING SUMMARY DATA BASED MENDELIAN RANDOMIZATION [PDF]

, 2019
IDENTIFYING CAUSAL GENETIC VARIANTS IN PSYCHIATRIC DISORDERS USING SUMMARY DATA BASED MENDELIAN ...
Straub, Richard E., Pergola, Giulio, Chen, Qiang, Kleinman, Joel E., Sadashivaiah, Vijay, Jaffe, Andrew E., Shin, Joo Heon, Radulescu, Eugenia, Hyde, Thomas M., Weinberger, Daniel R.   +9 more
core   +1 more source

Evolution of dominance in gene expression pattern associated with phenotypic robustness

BMC Ecology and Evolution, 2021
Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
doaj   +1 more source

COVID-19 is associated with the risk of cardiovascular disease death: A two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
doaj   +1 more source

Response to mass selection when an identified major gene is segregating [PDF]

, 1998
A deterministic model to predict response with mass selection when a major locus is segregating is presented. The model uses a selection index framework in which the weight of the different components included in the index are adjusted to describe the ...
Ricardo Pong-Wong, Pong-Wong, R.; id_orcid, John A. Woolliams, Woolliams, John, John A Woolliams   +4 more
core   +1 more source