Results 21 to 30 of about 248,446 (274)

Evolution of dominance in gene expression pattern associated with phenotypic robustness

BMC Ecology and Evolution, 2021
Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
doaj   +1 more source

Efficient allelic-drive in Drosophila. [PDF]

, 2019
Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single ...
Berni, Mateus, Bier, Ethan, Bobik, Marketta, Gantz, Valentino M, Guichard, Annabel, Haque, Tisha, Kaduskar, Bhagyashree, Klanseck, Carissa, Kushwah, Raja Babu Singh, Xu, Xiang-Ru S   +9 more
core   +3 more sources

COVID-19 is associated with the risk of cardiovascular disease death: A two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
doaj   +1 more source

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]

, 2018
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo, Alver, Maris, Bloom, Jonathan M, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Engreitz, Jesse M, Ernst, Jason, Esko, Tonu, Ganna, Andrea, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Khera, Amit V, Lander, Eric S, Manichaikul, Ani, Mitchell, Braxton, Montasser, May, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, O'Connell, Jeffrey R, Peloso, Gina M, Perry, James A, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni E, Salomaa, Veikko, Seed, Cotton, Surakka, Ida L, Vasan, Ramachandran S, Willer, Cristen J, Wilson, James G, Zekavat, Seyedeh Maryam, Zhou, Wei   +36 more
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Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment [PDF]

, 2018
Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal ...
Strawbridge, Rona J., van Zuydam, Natalie R.   +1 more
core   +1 more source

MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2020
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent, Christopher N. Foley, Andrew J. Grant, Amy M. Mason, James R. Staley, Stephen Burgess   +5 more
doaj   +1 more source

Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance [PDF]

Journal of Neurochemistry, 2016
Abstract Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease ( PD ) is associated with resting tremor, postural instability,
Hernandez, Dena G, Reed, Xylena, Singleton, Andrew B   +2 more
openaire   +2 more sources

Genes in the postgenomic era [PDF]

, 2006
We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype ...
B. Alberts, B. Alberts, C. Finta, C. Kenneth Waters, C. Kenneth Waters, C. Kenneth Waters, D. Communi, D. Kampa, E.M. Neumann-Held, Frederic L. Holmes, G. Stent, George C Williams, Karola Stotz, Karola Stotz, Karola Stotz, Kim Sterelny, Lenny Moss, M Burian Richard, M.W Gray, Marcel Weber, Michael Morange, Michael R Dietrich, Michael R Dietrich, Niall Dillon, P. Kapranov, P.S.R. Coelho, Paul E. Griffiths, Pavel V. Baranov, Petter Portin, Raphael Falk, Raphael Falk, Richard Dawkins, Richard Dawkins, Robert C Olby, T. Blumenthal, Thomas Hunt Morgan, Thomas Kuhn, Thomas. Fogle, Y. Chapdelaine   +38 more
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Key mendelian variants [PDF]

Nature Genetics, 2015
Genetic comparison of the effects of mutant and wild-type alleles is a powerful way to define gene function. But those few disease-causing variants that provide qualitatively different insights into the disease mechanisms of more common sporadic diseases have the greatest translational value.
openaire   +2 more sources

Mendelian and non-Mendelian genetics in model plants

The Plant Cell, 2022
Abstract The “Mendelian Rules” of inheritance are cornerstones of genetics, described in Mendel’s seminal publication from 1866. The experimental results and their interpretation have been discussed in numerous ways. This perspective emphasizes the contribution of Mendel’s preparations prior to his crossing experiments to the discovery ...
openaire   +2 more sources