Results 91 to 100 of about 4,310,301 (302)

Imputation of low‐density marker chip data in plant breeding: Evaluation of methods based on sugar beet

The Plant Genome, Volume 15, Issue 4, December 2022., 2022
Abstract Low‐density genotyping followed by imputation reduces genotyping costs while still providing high‐density marker information. An increased marker density has the potential to improve the outcome of all applications that are based on genomic data.
Tobias Niehoff, Torsten Pook, Mahmood Gholami, Timothy Beissinger   +3 more
wiley   +1 more source

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

International Journal of Epidemiology, 2016
Background: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments.
J. Bowden, F. Del Greco M, C. Minelli, G. Davey Smith, N. Sheehan, J. Thompson   +5 more
semanticscholar   +1 more source

Estimating Malaria Vaccine Efficacy in the Absence of a Gold Standard Case Definition: Mendelian Factorial Design [PDF]

arXiv, 2019
Accurate estimates of malaria vaccine efficacy require a reliable definition of a malaria case. However, the symptoms of clinical malaria are unspecific, overlapping with other childhood illnesses. Additionally, children in endemic areas tolerate varying levels of parasitemia without symptoms.
arxiv  

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

Epidemiology, 2016
Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the increasing availability of summarized data on genetic associations with risk ...
S. Burgess, J. Bowden, T. Fall, E. Ingelsson, S. Thompson   +4 more
semanticscholar   +1 more source

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score [PDF]

Annals of Statistics, 2018
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science.
Qingyuan Zhao, Jingshu Wang, G. Hemani, J. Bowden, Dylan S. Small   +4 more
semanticscholar   +1 more source

Mendelian randomization and colocalization analyses reveal an association between short sleep duration or morning chronotype and altered leukocyte telomere length

Communications Biology, 2023
Observational studies suggest certain sleep traits are associated with telomere length, but the causal nature of these associations is unclear. The study aimed to determine the causal associations between 11 sleep-related traits and leukocyte telomere ...
Jingyi Hu, Jiawen Lu, Qiuhan Lu, Weipin Weng, Zixuan Guan, Zhenqian Wang   +5 more
doaj   +1 more source

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M. McKeigue   +9 more
wiley   +1 more source

Immunocytes do not mediate food intake and the causal relationship with allergic rhinitis: a comprehensive Mendelian randomization

Frontiers in Nutrition
BackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing ...
Zhi-qiang Zhang, Jing-yang Li, You-wei Bao, Yu-Qi Song, Dong-xu Song, Cheng Wang, Xin-hua Zhu   +6 more
doaj   +1 more source

The promise and challenges of characterizing genome‐wide structural variants: A case study in a critically endangered parrot

Molecular Ecology Resources, EarlyView., 2023
Abstract There is growing interest in the role of structural variants (SVs) as drivers of local adaptation and speciation. From a biodiversity genomics perspective, the characterization of genome‐wide SVs provides an exciting opportunity to complement single nucleotide polymorphisms (SNPs). However, little is known about the impacts of SV discovery and
Jana R. Wold, Joseph G. Guhlin, Peter K. Dearden, Anna W. Santure, Tammy E. Steeves   +4 more
wiley   +1 more source

A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data revealed causal relationship between heavy cigarette dependence and Barrett’s esophagus

SAGE Open Medicine
Background: The association between smoking dependence and the risk of developing Barrett’s esophagus remains unclear. This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using ...
Zhou An, Meichun Zeng, Xianhua Wang
doaj   +1 more source