Results 91 to 100 of about 51,589 (295)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis

Frontiers in Cardiovascular Medicine
ObjectiveInflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to ...
Xuanchun Huang, Lanshuo Hu, Jun Li, Shiyi Tao, Tiantian Xue   +4 more
doaj   +1 more source

Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk [PDF]

, 2007
Carlotta Sacerdote, Simonetta Guarrera, George Davey Smith, Sara Grioni, Vittorio Krogh, Giovanna Masala, Amalia Mattiello, Domenico Palli, Salvatore Panico, ­Rosario ­Tumino, Fabrizio Veglia, Giuseppe Matullo, P. Vineis   +12 more
openalex   +1 more source

Mendelian Randomization Analysis in Observational Epidemiology

Journal of Lipid and Atherosclerosis, 2019
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
openaire   +3 more sources

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Arthritis &Rheumatology, EarlyView.
Jie Zheng, George Davey Smith, Jonathan H. Tobias   +2 more
wiley   +1 more source

Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective The gut microbiota (GM) plays a role in epilepsy development via the microbiota–gut–brain axis. However, its relationship with various epilepsy subtypes and its mediating role through immune cells remain unclear. Thus, identifying the GM linked to specific epilepsy subtypes and investigating immune mechanisms to predict epilepsy risk,
Xu Zhang, Zhenlin Yang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Capitalizing on Mendelian randomization to assess the effects of treatments [PDF]

, 2007
George Davey Smith
openalex   +1 more source

Food Addiction Is Strongly Associated With Psychopathology and Reduced Psychological Well‐Being Among Adults Irrespective of BMI

European Eating Disorders Review, EarlyView.
ABSTRACT Background and Aims Food addiction has been linked to psychopathology and reduced psychological well‐being. Here, we investigated whether these associations are mainly driven by food addiction itself or mediated via an increase in BMI. Methods Data stem from a nationwide survey from Denmark (n = 1474 participants).
Christina Horsager, Emil Færk, Jens Meldgaard Bruun, Marlene B. Lauritsen, Søren Dinesen Østergaard   +4 more
wiley   +1 more source

Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Epigenetics & Chromatin
Background The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple ...
Hongwei Liu, Hanqing Zhang, Zhaoxu Yin, Miaomiao Hou   +3 more
doaj   +1 more source

Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization [PDF]

, 2008
George Davey Smith, Nicholas J. Timpson, Shah Ebrahim   +2 more
openalex   +1 more source