Results 71 to 80 of about 4,939,244 (349)
Mendelian randomisation for nutritional psychiatry [PDF]
The Lancet Psychiatry, 2020 Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients.Carnegie, Rebecca, Zheng, Jie, Sallis, Hannah M, Jones, Hannah J, Wade, Kaitlin H, Zammit, Stan, Evans, Jonathan, Zammit, Stan, Munafò, Marcus R, Martin, Richard M +9 moreopenaire +5 more sourcesG3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou +9 morewiley +1 more sourceMendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
Nature Communications, 2020 Mendelian randomization is a useful tool to infer causal relationships between traits, but can be confounded by the presence of pleiotropy. Here, the authors have developed MR-link, a Mendelian randomization method which accounts for unobserved ...Adriaan van der Graaf, Annique Claringbould, Antoine Rimbert, BIOS Consortium, Harm-Jan Westra, Yang Li, Cisca Wijmenga, Serena Sanna +7 moredoaj +1 more sourceAndrogen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma +18 morewiley +1 more sourceStratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers [PDF]
, 2014 We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis.Kumari, Meena, Paternoster, Lavinia, Postmus, Iris, Bjørngaard, Johan Håkon, Frayling Tim, Räikkönen, Katri, Munafò, Marcus R., Caroline Hayward (149856), Power Christine, Ahluwalia, TS, Sorensen, Thorkild I. A., Kirsten Ohm Kyvik (75576), Gabrielsen, Maiken Elvestad, Johan H Bjorngaard, Christiansen, Lene, Meg E. Fluharty (669886), Kyvik, KO, Smith, BH, Sandosh Padmanabhan (238533), Padmanabhan Sandosh, Wannamethee S. Goya, Morris Richard W., Kaprio, Jaakko, Cavadino, Alana, Peter H Whincup, Wannamethee, S. Goya, Whincup, PH, Martin Preisig, Vink, JM, Ford, I, Davey Smith George, Hällfors Jenni, Marioni, Riccardo R., Kyvik, Kirsten Ohm, Marques-Vidal, P, Marques-Vidal Pedro, Davey Smith, George, Cavadino, A, Skaaby, Tea, Vink, J.M., Lawlor, Debbie, Taylor Amy E., Ohm Kyvik, Kirsten; id_orcid, Wannamethee, S Goya, Marika Kaakinen, Taylor, A.E., Lavinia Paternoster (153181), Treur, J., Eriksson, Johan, Ahluwalia, T., Dale, C., Munafò, MR, Iris Postmus, Watt, G, Husemoen, Lise Lotte N., Treur, J.L., J. Wouter Jukema (127361), Jarvelin, Marjo-Riitta, Kisialiou Aliaksei, Nohr, EA, Davey Smith, G., Jukema, JW, Wong, A., Jari Lahti, Hällfors, J., Paternoster, L., Romundstad Pål R., Sattar, N, Smith, GD, Fergusson, D., Aarno Palotie (41342), Palotie, A, Ian Ford, Pål R Romundstad, Martin A Kennedy, Lavinia Paternoster, Dale Caroline, Kaprio Jaakko, Wannamethee, SG, Hyppönen, E., Tim Frayling, Eriksson, J, Linneberg Allan, Naveed Sattar, Ford, Ian, et al., Jenni Hällfors (669893), Dalgård, Christine, Postmus Iris, Fluharty, M.E., Tarunveer S. Ahluwalia (418885), Maiken E Gabrielsen, Linneberg, A., Husemoen, L., Palotie, A., Christine Dalgård, Bjørn Olav Åsvold (669889), Jarvelin Marjo-Riitta, Sorensen, TIA, Kisialiou, A., David M Fergusson, Husemoen, LL, Sørensen, Thorkild I. A., Bjorngaard, J.H., Bjorngaard, Johan H., Andrew Wong (256256), Treur, Jorien L, Ahluwalia, Tarunveer Singh, Alex McConnachie, Fergusson, DM, Ahluwalia, Tarunveer S, Lene Christiansen, Sørensen, Thorkild I.A., George Davey Smith, Sørensen, T.I.A., Hyppönen, Elina, Graham Watt (246706), Borodulin, Katja, Ohm Kyvik Kirsten, Ohm Kyvik, K., Campbell, A., Kuh, D., Kumari Meena, Andrew Wong, Borodulin Katja, Wong, A, Jari Lahti (149903), Husemoen, LLN, Fergusson, D, Frayling, Tim, Richard W Morris, Eriksson Johan, Asvold, B.O., Räikkönen Katri, Ellen A. Nohr (162402), Elina Hyppönen (163747), Männistö, Satu, McConnachie, A, Johan Eriksson, Alana Cavadino (448066), Smith, B.H., Martin Preisig (111534), Elina Hyppönen, Johan Eriksson (131534), Lene Christiansen (158189), Lahti, J., Marioni, R, Kaakinen Marika, Jukema, J.W., Fergusson David M., Whincup, P.H., Preisig, M, Gabrielsen, Maiken E., Pål R. Romundstad (420886), Power, C, Tyrrell, Jessica, Katja Borodulin, Archie Campbell (669891), Taylor, Amy E., McConnachie Alex, Kivimaki Mika, Smith, Blair H., Meg E Fluharty, Tea Skaaby (292885), Ben-Shlomo, Y., Preisig, Martin, Marjo-Riitta Jarvelin (110290), Marioni, R., Borodulin, K., Kumari, M., Jarvelin, MR, Hällfors, J, Sørensen, TI, Kennedy, M.A., Fluharty, ME, Fluharty, M., Alex McConnachie (104022), Vink Jacqueline M., Ben-Shlomo, Y, Nohr, Ellen A, Ian Ford (30666), Dalgård Christine, John Horwood (669895), Nohr Ellen A., Nohr, Ellen A., Smith, Blair H.; id_orcid, Munafo, M.R., Tarunveer S Ahluwalia, Satu Männistö, Taylor, Amy E, Romundstad, P.R., Marika Kaakinen (116620), Kisialiou, A, Marcus R Munafò, Männistö, S, Vink, Jacqueline M, Kennedy Martin A., Kivimaki, M., Tyrrell, J, Horwood, J., Postmus, I, Bjorngaard, Johan H, Hayward, C, Asvold, Bjørn Olav, Sørensen, Thorkild I A, Amy E. Taylor (111604), Horwood, John, Linneberg, A, Lawlor, D, Aliaksei Kisialiou (267828), Jessica Tyrrell (482364), Debbie Lawlor, Kivimaki, M, Jacqueline M Vink, Ohm Kyvik, K, Christine Power, Whincup, Peter H., Marjo-Riitta Jarvelin, Munafò Marcus R., Asvold, Bjorn Olav, Watt, G., Hyppönen Elina, Marioni, Riccardo, Ford Ian, Sørensen Thorkild I. A., Romundstad, PR, Yoav Ben-Shlomo, Watt, Graham, Åsvold Bjørn Olav, Kumari, M, Pedro Marques-Vidal, Jaakko Kaprio (43154), Frayling, T, Fergusson, D.M., Ellen A Nohr, Palotie Aarno, Satu Männistö (201550), Kaakinen, M, Maiken E. Gabrielsen (669890), Sorensen, T.I.A., Pedro Marques-Vidal (58558), Allan Linneberg, Martin A. Kennedy (278135), Katja Borodulin (669897), Sørensen, Thorkild IA, Jessica Tyrrell, Kaakinen, Marika, Bjorngaard, J., Hayward, C., Åsvold, BO, Kivimaki, Mika, Jukema, J. Wouter, Christiansen, L., Jorien L Treur, Jukema, J Wouter, Fluharty, Meg E, Sattar Naveed, Marques-Vidal, Pedro, Power, Christine, Horwood John, Bjorngaard, JH, Archie Campbell, Kuh, Diana, Campbell, A, Naveed Sattar (8785), Dorret I Boomsma, Gonneke Willemsen (75573), Räikkönen, K, Blair H. Smith (625812), Whincup, Peter H, J Wouter Jukema, Sattar, Naveed, Diana Kuh, Palotie, Aarno, Kaprio, J., Christine Power (448073), Dorret I. Boomsma (109746), Dale, C, Kirsten Ohm Kyvik, Thorkild I. A. Sørensen (37671), Ahluwalia, Tarun Veer Singh, Mika Kivimaki (2222011), S Goya Wannamethee, Kuh Diana, Cavadino Alana, George Davey Smith (82619), Smith, G.D., Husemoen, Lise Lotte N, Hyppönen, E, Nohr, Ellen A; id_orcid, Frayling, T., Dale, Caroline, Kennedy, MA, Boomsma Dorret I., Eriksson, J., Morris, R., Richard W. Morris (351802), Power, C., Lahti, Jari, Åsvold, B., Tyrrell Jessica, Lawlor, D., Willemsen, Gonneke, Jarvelin, M-R, Campbell, Archie, Sorensen, Thorkild, Borodulin, K, Dalgård, C, Jenni Hällfors, Padmanabhan, Sandosh, Katri Räikkönen (149957), Männistö Satu, Lise Lotte N. Husemoen (244333), Fluharty Meg E., Morris, RW, Horwood, L.J., Marioni Riccardo, Kennedy, Martin A., Blair H Smith, Gonneke Willemsen, Romundstad, Pål R., Ahluwalia Tarunveer S., Dalgård, Christine; id_orcid, Ohm Kyvik, Kirsten, Skaaby Tea, Marques-Vidal, P., Davey Smith, G, Kaprio, J, Jukema J. Wouter, Treur, Jorien L., Kuh, D, Watt Graham, Willemsen, G, Caroline Hayward, Boomsma, D.I.; id_orcid, Allan Linneberg (139773), Tea Skaaby, Männistö, S., Morris, R.W., Taylor, AE, Marcus R. Munafò (171830), Boomsma, Dorret I, Fergusson, David M, Riccardo Marioni (669892), Christiansen, L, Cavadino, A., Caroline Dale, Campbell Archie, Lahti, J, Ahluwalia, Tarunveer S., Willemsen, G.; id_orcid, Morris, Richard W., Bjørn Olav Åsvold, Caroline Dale (448065), David M. Fergusson (278134), Munafò, Marcus R, Meena Kumari (95278), Romundstad, Pål R, Graham Watt, Hayward Caroline, Taylor, A., Johan H. Bjorngaard (669888), Postmus, I., Smith, George Davey, Bjorngaard Johan H., Treur Jorien L., Paternoster Lavinia, Nohr, E.A., Boomsma, Dorret I., Husemoen, L.L., Ben-Shlomo, Yoav, Hayward, Caroline, Husemoen, L.L.N., Kaakinen, M., Smith Blair H., Sattar, N., Smith, Blair H, Lawlor, Debbie A, Ford, I., Linneberg, Allan, Romundstad, Pål Richard, Willemsen Gonneke, Alana Cavadino, S. Goya Wannamethee (669283), Lahti Jari, Wong Andrew, Vink, Jacqueline M., Peter H. Whincup (168892), Debbie Lawlor (669896), Kennedy, Martin A, Aarno Palotie, Boomsma, DI, Yoav Ben-Shlomo (95286), Lawlor Debbie, Katri Räikkönen, Padmanabhan, S, Gabrielsen Maiken E., Preisig Martin, Riccardo Marioni, Lise Lotte N Husemoen, Christine Dalgård (323021), Morris, Richard W, Mika Kivimaki, Järvelin, M.R., Treur, JL, Fluharty, Meg E., Amy E Taylor, Wannamethee, S.G., Meena Kumari, Räikkönen, K., Willemsen, G., Preisig, M., Husemoen Lise Lotte N., McConnachie, A., Jacqueline M. Vink (109713), Aliaksei Kisialiou, Padmanabhan, S., Hällfors, Jenni, Ahluwalia, T.S., Tim Frayling (157530), Horwood, J, Jaakko Kaprio, Gabrielsen, Maiken E, McConnachie, Alex, Boomsma, D.I., Fluharty, Meg, Fergusson, David M., Thorkild I A Sørensen, Frayling, T.M., Skaaby, T, Kisialiou, Aliaksei, Gabrielsen, M., Sørensen, T.I., Iris Postmus (312601), Skaaby, T., Christiansen Lene, Kyvik, K.O., Whincup Peter H., Jorien L. Treur (669894), Dalgard, C., Tyrrell, J., Sandosh Padmanabhan, Hayward, Caroline; id_orcid, Gabrielsen, ME, John Horwood, Wong, Andrew, Paternoster, L, Ben-Shlomo Yoav, Gabrielsen, M.E., Diana Kuh (188923) +449 morecore +1 more sourceMendelian randomization and pleiotropy analysis
Quantitative Biology, 2021 BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...openaire +3 more sourcesCis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa +9 morewiley +1 more source
