Results 51 to 60 of about 4,939,244 (349)

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

Statistics in Medicine, 2017
Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions.
J. Bowden, F. Del Greco M, C. Minelli, G. Davey Smith, N. Sheehan, John F. Thompson   +5 more
semanticscholar   +1 more source

Bilirubin, Gallstones, and Mendelian Randomization [PDF]

JAMA Internal Medicine, 2013
Gallstonedisease causes a substantialhealthandeconomicburden in theUnited States andother developed countries.More than 6millionmen and 14millionwomen aged 20 to 74 years in the United States have gallbladder disease.1 Approximately 650 000 to 700 000 cholecystectomies are performed annually in the United States, and the costs associated with the ...
openaire   +2 more sources

Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants

Epidemiology, 2016
Mendelian randomization investigations are becoming more powerful and simpler to perform, due to the increasing size and coverage of genome-wide association studies and the increasing availability of summarized data on genetic associations with risk ...
S. Burgess, J. Bowden, T. Fall, E. Ingelsson, S. Thompson   +4 more
semanticscholar   +1 more source

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects [PDF]

, 2011
Background Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism.
Craen, A.J.M., Westendorp, R.G., P. Eline Slagboom, Anton J. M. de Craen, Kromhout, D., Johanna M. Geleijnse, Craen, A.J.M. de, Erik J. Giltay, Rius-Ottenheim, N., Rudi G. Westendorp, Geleijnse, J.M., Giltay, E.J., Slagboom, P.E., Mast, R.C. van der, Nathaly Rius-Ottenheim, Daan Kromhout, Frans G. Zitman, Roos C. van der Mast, Zitman, F.G., Rius Ottenheim, N.   +19 more
core   +1 more source

The basic principles underlying Mendelian randomization.

, 2021
Fig 1A is the three assumptions for Mendelian randomization analysis. Fig 1B is the basic principles of bi-directional Mendelian randomization. SNP is the single nucleotide polymorphism and IV is the instrumental variable.
Zhenxing Tu (11576846), Hongquan Chen (4056973), Zhiguang Liu (174159), Jie Ding (73711)   +3 more
core   +1 more source

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

Evaluating the potential role of pleiotropy in Mendelian randomization studies

Human Molecular Genetics, 2018
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ...
G. Hemani, J. Bowden, G. Davey Smith
semanticscholar   +1 more source

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study

BMC Psychiatry, 2023
Background Complex immune-brain interactions that affect neural development, survival and function might have causal and therapeutic implications for psychiatric illnesses.
Chengdong Wang, Dongdong Zhu, Dongjun Zhang, Xiaowei Zuo, Lei Yao, Teng Liu, Xiaodan Ge, Chenlu He, Yuan Zhou, Ziyuan Shen   +9 more
semanticscholar   +1 more source

Mendelian randomization in nutritional epidemiology [PDF]

Nutrition Reviews, 2009
Nutritional epidemiology aims to identify dietary and lifestyle causes for human diseases. Causality inference in nutritional epidemiology is largely based on evidence from studies of observational design, and may be distorted by unmeasured or residual confounding and reverse causation.
openaire   +2 more sources

Causal relationship among obesity and body fat distribution and epilepsy subtypes

Frontiers in Neurology, 2022
ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality.
Kaiping Zhou, Huan Yang, Ruomeng Chen, Weiping Wang, Zhenzhen Qu   +4 more
doaj   +1 more source