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Smoking and stroke: A mendelian randomization study [PDF]
Annals of Neurology, 2019 We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630 noncases, and 1,545 cases of intracerebral hemorrhage and 1,481 noncases.Larsson, Susanna C, Burgess, Stephen, Michaëlsson, Karl +2 moreopenaire +4 more sourcesStratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers [PDF]
, 2014 We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis.Kumari, Meena, Paternoster, Lavinia, Postmus, Iris, Bjørngaard, Johan Håkon, Frayling Tim, Räikkönen, Katri, Munafò, Marcus R., Caroline Hayward (149856), Power Christine, Ahluwalia, TS, Sorensen, Thorkild I. A., Kirsten Ohm Kyvik (75576), Gabrielsen, Maiken Elvestad, Johan H Bjorngaard, Christiansen, Lene, Meg E. Fluharty (669886), Kyvik, KO, Smith, BH, Sandosh Padmanabhan (238533), Padmanabhan Sandosh, Wannamethee S. Goya, Morris Richard W., Kaprio, Jaakko, Cavadino, Alana, Peter H Whincup, Wannamethee, S. Goya, Whincup, PH, Martin Preisig, Vink, JM, Ford, I, Davey Smith George, Hällfors Jenni, Marioni, Riccardo R., Kyvik, Kirsten Ohm, Marques-Vidal, P, Marques-Vidal Pedro, Davey Smith, George, Cavadino, A, Skaaby, Tea, Vink, J.M., Lawlor, Debbie, Taylor Amy E., Ohm Kyvik, Kirsten; id_orcid, Wannamethee, S Goya, Marika Kaakinen, Taylor, A.E., Lavinia Paternoster (153181), Treur, J., Eriksson, Johan, Ahluwalia, T., Dale, C., Munafò, MR, Iris Postmus, Watt, G, Husemoen, Lise Lotte N., Treur, J.L., J. Wouter Jukema (127361), Jarvelin, Marjo-Riitta, Kisialiou Aliaksei, Nohr, EA, Davey Smith, G., Jukema, JW, Wong, A., Jari Lahti, Hällfors, J., Paternoster, L., Romundstad Pål R., Sattar, N, Smith, GD, Fergusson, D., Aarno Palotie (41342), Palotie, A, Ian Ford, Pål R Romundstad, Martin A Kennedy, Lavinia Paternoster, Dale Caroline, Kaprio Jaakko, Wannamethee, SG, Hyppönen, E., Tim Frayling, Eriksson, J, Linneberg Allan, Naveed Sattar, Ford, Ian, et al., Jenni Hällfors (669893), Dalgård, Christine, Postmus Iris, Fluharty, M.E., Tarunveer S. Ahluwalia (418885), Maiken E Gabrielsen, Linneberg, A., Husemoen, L., Palotie, A., Christine Dalgård, Bjørn Olav Åsvold (669889), Jarvelin Marjo-Riitta, Sorensen, TIA, Kisialiou, A., David M Fergusson, Husemoen, LL, Sørensen, Thorkild I. A., Bjorngaard, J.H., Bjorngaard, Johan H., Andrew Wong (256256), Treur, Jorien L, Ahluwalia, Tarunveer Singh, Alex McConnachie, Fergusson, DM, Ahluwalia, Tarunveer S, Lene Christiansen, Sørensen, Thorkild I.A., George Davey Smith, Sørensen, T.I.A., Hyppönen, Elina, Graham Watt (246706), Borodulin, Katja, Ohm Kyvik Kirsten, Ohm Kyvik, K., Campbell, A., Kuh, D., Kumari Meena, Andrew Wong, Borodulin Katja, Wong, A, Jari Lahti (149903), Husemoen, LLN, Fergusson, D, Frayling, Tim, Richard W Morris, Eriksson Johan, Asvold, B.O., Räikkönen Katri, Ellen A. Nohr (162402), Elina Hyppönen (163747), Männistö, Satu, McConnachie, A, Johan Eriksson, Alana Cavadino (448066), Smith, B.H., Martin Preisig (111534), Elina Hyppönen, Johan Eriksson (131534), Lene Christiansen (158189), Lahti, J., Marioni, R, Kaakinen Marika, Jukema, J.W., Fergusson David M., Whincup, P.H., Preisig, M, Gabrielsen, Maiken E., Pål R. Romundstad (420886), Power, C, Tyrrell, Jessica, Katja Borodulin, Archie Campbell (669891), Taylor, Amy E., McConnachie Alex, Kivimaki Mika, Smith, Blair H., Meg E Fluharty, Tea Skaaby (292885), Ben-Shlomo, Y., Preisig, Martin, Marjo-Riitta Jarvelin (110290), Marioni, R., Borodulin, K., Kumari, M., Jarvelin, MR, Hällfors, J, Sørensen, TI, Kennedy, M.A., Fluharty, ME, Fluharty, M., Alex McConnachie (104022), Vink Jacqueline M., Ben-Shlomo, Y, Nohr, Ellen A, Ian Ford (30666), Dalgård Christine, John Horwood (669895), Nohr Ellen A., Nohr, Ellen A., Smith, Blair H.; id_orcid, Munafo, M.R., Tarunveer S Ahluwalia, Satu Männistö, Taylor, Amy E, Romundstad, P.R., Marika Kaakinen (116620), Kisialiou, A, Marcus R Munafò, Männistö, S, Vink, Jacqueline M, Kennedy Martin A., Kivimaki, M., Tyrrell, J, Horwood, J., Postmus, I, Bjorngaard, Johan H, Hayward, C, Asvold, Bjørn Olav, Sørensen, Thorkild I A, Amy E. Taylor (111604), Horwood, John, Linneberg, A, Lawlor, D, Aliaksei Kisialiou (267828), Jessica Tyrrell (482364), Debbie Lawlor, Kivimaki, M, Jacqueline M Vink, Ohm Kyvik, K, Christine Power, Whincup, Peter H., Marjo-Riitta Jarvelin, Munafò Marcus R., Asvold, Bjorn Olav, Watt, G., Hyppönen Elina, Marioni, Riccardo, Ford Ian, Sørensen Thorkild I. A., Romundstad, PR, Yoav Ben-Shlomo, Watt, Graham, Åsvold Bjørn Olav, Kumari, M, Pedro Marques-Vidal, Jaakko Kaprio (43154), Frayling, T, Fergusson, D.M., Ellen A Nohr, Palotie Aarno, Satu Männistö (201550), Kaakinen, M, Maiken E. Gabrielsen (669890), Sorensen, T.I.A., Pedro Marques-Vidal (58558), Allan Linneberg, Martin A. Kennedy (278135), Katja Borodulin (669897), Sørensen, Thorkild IA, Jessica Tyrrell, Kaakinen, Marika, Bjorngaard, J., Hayward, C., Åsvold, BO, Kivimaki, Mika, Jukema, J. Wouter, Christiansen, L., Jorien L Treur, Jukema, J Wouter, Fluharty, Meg E, Sattar Naveed, Marques-Vidal, Pedro, Power, Christine, Horwood John, Bjorngaard, JH, Archie Campbell, Kuh, Diana, Campbell, A, Naveed Sattar (8785), Dorret I Boomsma, Gonneke Willemsen (75573), Räikkönen, K, Blair H. Smith (625812), Whincup, Peter H, J Wouter Jukema, Sattar, Naveed, Diana Kuh, Palotie, Aarno, Kaprio, J., Christine Power (448073), Dorret I. Boomsma (109746), Dale, C, Kirsten Ohm Kyvik, Thorkild I. A. Sørensen (37671), Ahluwalia, Tarun Veer Singh, Mika Kivimaki (2222011), S Goya Wannamethee, Kuh Diana, Cavadino Alana, George Davey Smith (82619), Smith, G.D., Husemoen, Lise Lotte N, Hyppönen, E, Nohr, Ellen A; id_orcid, Frayling, T., Dale, Caroline, Kennedy, MA, Boomsma Dorret I., Eriksson, J., Morris, R., Richard W. Morris (351802), Power, C., Lahti, Jari, Åsvold, B., Tyrrell Jessica, Lawlor, D., Willemsen, Gonneke, Jarvelin, M-R, Campbell, Archie, Sorensen, Thorkild, Borodulin, K, Dalgård, C, Jenni Hällfors, Padmanabhan, Sandosh, Katri Räikkönen (149957), Männistö Satu, Lise Lotte N. Husemoen (244333), Fluharty Meg E., Morris, RW, Horwood, L.J., Marioni Riccardo, Kennedy, Martin A., Blair H Smith, Gonneke Willemsen, Romundstad, Pål R., Ahluwalia Tarunveer S., Dalgård, Christine; id_orcid, Ohm Kyvik, Kirsten, Skaaby Tea, Marques-Vidal, P., Davey Smith, G, Kaprio, J, Jukema J. Wouter, Treur, Jorien L., Kuh, D, Watt Graham, Willemsen, G, Caroline Hayward, Boomsma, D.I.; id_orcid, Allan Linneberg (139773), Tea Skaaby, Männistö, S., Morris, R.W., Taylor, AE, Marcus R. Munafò (171830), Boomsma, Dorret I, Fergusson, David M, Riccardo Marioni (669892), Christiansen, L, Cavadino, A., Caroline Dale, Campbell Archie, Lahti, J, Ahluwalia, Tarunveer S., Willemsen, G.; id_orcid, Morris, Richard W., Bjørn Olav Åsvold, Caroline Dale (448065), David M. Fergusson (278134), Munafò, Marcus R, Meena Kumari (95278), Romundstad, Pål R, Graham Watt, Hayward Caroline, Taylor, A., Johan H. Bjorngaard (669888), Postmus, I., Smith, George Davey, Bjorngaard Johan H., Treur Jorien L., Paternoster Lavinia, Nohr, E.A., Boomsma, Dorret I., Husemoen, L.L., Ben-Shlomo, Yoav, Hayward, Caroline, Husemoen, L.L.N., Kaakinen, M., Smith Blair H., Sattar, N., Smith, Blair H, Lawlor, Debbie A, Ford, I., Linneberg, Allan, Romundstad, Pål Richard, Willemsen Gonneke, Alana Cavadino, S. Goya Wannamethee (669283), Lahti Jari, Wong Andrew, Vink, Jacqueline M., Peter H. Whincup (168892), Debbie Lawlor (669896), Kennedy, Martin A, Aarno Palotie, Boomsma, DI, Yoav Ben-Shlomo (95286), Lawlor Debbie, Katri Räikkönen, Padmanabhan, S, Gabrielsen Maiken E., Preisig Martin, Riccardo Marioni, Lise Lotte N Husemoen, Christine Dalgård (323021), Morris, Richard W, Mika Kivimaki, Järvelin, M.R., Treur, JL, Fluharty, Meg E., Amy E Taylor, Wannamethee, S.G., Meena Kumari, Räikkönen, K., Willemsen, G., Preisig, M., Husemoen Lise Lotte N., McConnachie, A., Jacqueline M. Vink (109713), Aliaksei Kisialiou, Padmanabhan, S., Hällfors, Jenni, Ahluwalia, T.S., Tim Frayling (157530), Horwood, J, Jaakko Kaprio, Gabrielsen, Maiken E, McConnachie, Alex, Boomsma, D.I., Fluharty, Meg, Fergusson, David M., Thorkild I A Sørensen, Frayling, T.M., Skaaby, T, Kisialiou, Aliaksei, Gabrielsen, M., Sørensen, T.I., Iris Postmus (312601), Skaaby, T., Christiansen Lene, Kyvik, K.O., Whincup Peter H., Jorien L. Treur (669894), Dalgard, C., Tyrrell, J., Sandosh Padmanabhan, Hayward, Caroline; id_orcid, Gabrielsen, ME, John Horwood, Wong, Andrew, Paternoster, L, Ben-Shlomo Yoav, Gabrielsen, M.E., Diana Kuh (188923) +449 morecore +1 more sourceChronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...Anu Singh, Aroonima Misra, Sufian Zaheerwiley +1 more sourceExtensions to Mendelian randomization
, 2009 The Mendelian randomization approach is concerned with the causal pathway between a gene, an intermediate phenotype and a disease. The aim of the approach is to estimate the causal association between the phenotype and the disease when confounding or ...Thompson, J, Palmer, Thomas Mcore +7 more sourcesRecent Developments in Mendelian Randomization Studies [PDF]
Current Epidemiology Reports, 2017 Mendelian randomization (MR) is a strategy for evaluating causality in observational epidemiological studies. MR exploits the fact that genotypes are not generally susceptible to reverse causation and confounding, due to their fixed nature and Mendel's First and Second Laws of Inheritance.Zheng, Jie, Baird, Denis, Borges, Carolina, Bowden, Jack, Hemani, Gibran, Haycock, Philip, Evans, David M, Davey Smith, George +7 moreopenaire +5 more sourcesMendelian randomisation for nutritional psychiatry [PDF]
The Lancet Psychiatry, 2020 Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the cause of psychiatric ill-health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small effect sizes for individual nutrients.Carnegie, Rebecca, Zheng, Jie, Sallis, Hannah M, Jones, Hannah J, Wade, Kaitlin H, Zammit, Stan, Evans, Jonathan, Zammit, Stan, Munafò, Marcus R, Martin, Richard M +9 moreopenaire +5 more sources
