Results 41 to 50 of about 81,479 (293)
Biomarkers and type 2 diabetes [PDF]
, 2015 This is the author accepted manuscript. The final version is available from Bioscientifica via http://dx.doi.org/10.1530/EC-15-0087Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations.
Abbasi, Ali
core +4 more sources
Frontiers in Public HealthBackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao +4 more
doaj +1 more source
Causal relationship among obesity and body fat distribution and epilepsy subtypes
Frontiers in Neurology, 2022 ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality.
Kaiping Zhou +4 more
doaj +1 more source
Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score [PDF]
, 2019 Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science.
Bowden, Jack +4 more
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Mendelian randomization and pleiotropy analysis
Quantitative Biology, 2021 BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
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Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
SAGE Open MedicineBackground: Rheumatoid arthritis might increase the risk of lung diseases, such as interstitial lung disease and lung cancer. However, the causal relationships remained unclear.
Shengkai Zhang +5 more
doaj +1 more source
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source
Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates [PDF]
, 2018 Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of ...
Burgess, S. (Stephen) +1 more
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Bilirubin, Gallstones, and Mendelian Randomization [PDF]
JAMA Internal Medicine, 2013 Gallstonedisease causes a substantialhealthandeconomicburden in theUnited States andother developed countries.More than 6millionmen and 14millionwomen aged 20 to 74 years in the United States have gallbladder disease.1 Approximately 650 000 to 700 000 cholecystectomies are performed annually in the United States, and the costs associated with the ...
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