Results 41 to 50 of about 143,068 (301)

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects [PDF]

, 2011
Background Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism.
Craen, A.J.M., Westendorp, R.G., P. Eline Slagboom, Anton J. M. de Craen, Kromhout, D., Johanna M. Geleijnse, Craen, A.J.M. de, Erik J. Giltay, Rius-Ottenheim, N., Rudi G. Westendorp, Geleijnse, J.M., Giltay, E.J., Slagboom, P.E., Mast, R.C. van der, Nathaly Rius-Ottenheim, Daan Kromhout, Frans G. Zitman, Roos C. van der Mast, Zitman, F.G., Rius Ottenheim, N.   +19 more
core   +1 more source

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj   +1 more source

Mendelian randomization in family data [PDF]

BMC Proceedings, 2009
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques.
Morris, Nathan J, Gray-McGuire, Courtney, Stein, Catherine M   +2 more
openaire   +2 more sources

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

The basic principles underlying Mendelian randomization.

, 2021
Fig 1A is the three assumptions for Mendelian randomization analysis. Fig 1B is the basic principles of bi-directional Mendelian randomization. SNP is the single nucleotide polymorphism and IV is the instrumental variable.
Zhenxing Tu (11576846), Hongquan Chen (4056973), Zhiguang Liu (174159), Jie Ding (73711)   +3 more
core   +1 more source

Mendelian randomization in nutritional epidemiology [PDF]

Nutrition Reviews, 2009
Nutritional epidemiology aims to identify dietary and lifestyle causes for human diseases. Causality inference in nutritional epidemiology is largely based on evidence from studies of observational design, and may be distorted by unmeasured or residual confounding and reverse causation.
openaire   +2 more sources

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease.

, 2023
An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking.
Squassina, A., Royo, J.L., Sorbi, S., Scarmeas, N., Rujescu, D., Porcel, L.M., Nicolas, G., Galimberti, D., Mecocci, P., Soininen, H., Andreassen, O.A., Ruiz, A., Graff, C., Grenier-Boley, B., Kuulasmaa, T., Düzel, E., Grünblatt, E., Borroni, B., de Mendonça, A., Jürgen, D., Boada, M., Grimmer, T., Mehrabian, S., Tegos, T., Pérez-Tur, J., Schneider, A., Daniele, A., Moebus, S., Rodriguez-Rodriguez, E., Tremolizzo, L., Giedraitis, V., Ramirez, A., Clarimon, J., Lambert, J.C., de Rojas, I., Spalletta, G., Riedel-Heller, S., Van Duijn, C., Hausner, L., Kehoe, P., Solfrizzi, V., Parveen, K., Ingelsson, M., Seripa, D., Deleuze, J.F., Masullo, C., Frikke-Schmidt, R., Sánchez-Valle, R., Dufouil, C., Williams, J., Sleegers, K., García-González, P., Pastor, P., García-Alberca, J.M., Caffarra, P., Jessen, F., Bellenguez, C., Hanon, O., Luo, J., Nicolas, A., Heilmann-Heimbach, S., Mir, P., Bacq-Daian, D., Rainero, I., Álvarez, V., Rossi, G., Wiltfang, J., Moreno, F., Castillo, A., Papenberg, G., Tsolaki, M., Debette, S., Piñol-Ripoll, G., Amouyel, P., Real, L.M., Thomassen, J.Q., Scherbaum, N., Hort, J., Pasquier, F., Vyhnalek, M., Nacmias, B., Arosio, B., Benussi, L., Hiltunen, M., Sims, R., Peters, O., Boland, A., Popp, J., Parnetti, L., Küçükali, F., Dichgans, M., Puerta, R., van der Flier, W., Bullido, M.J., van der Lee, S., Sánchez-Juan, P.   +95 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source