Results 41 to 50 of about 4,939,244 (349)

Mendelian randomization in family data [PDF]

BMC Proceedings, 2009
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques.
Morris, Nathan J, Gray-McGuire, Courtney, Stein, Catherine M   +2 more
openaire   +2 more sources

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

Frontiers in Genetics, 2023
Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang, Duorui Nie, Yujing Chen, Zixing Liu, Mengzhao Li, Chun Gong, Qiong Liu   +6 more
doaj   +1 more source

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

International Journal of Epidemiology, 2017
MendelianRandomization is a software package for the R open-source software environment that performs Mendelian randomization analyses using summarized data.
O. Yavors’ka, S. Burgess
semanticscholar   +1 more source

Guidelines for performing Mendelian randomization investigations: update for summer 2023

Wellcome Open Research, 2019
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization ...
S. Burgess, G. D. Smith, N. Davies, F. Dudbridge, D. Gill, M. M. Glymour, F. Hartwig, Z. Kutalik, M. Holmes, C. Minelli, Jean Morrison, W. Pan, C. Relton, E. Theodoratou, S. Swanson   +14 more
semanticscholar   +1 more source

Multivariable Mendelian Randomization and Mediation [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to estimate the causal effect of that exposure on an outcome. Mediation analysis is the method of decomposing the effects of an exposure on an outcome, which act directly, and those that act via mediating variables.
openaire   +3 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj   +1 more source

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

bioRxiv, 2017
Background Mendelian randomisation (MR) is being increasingly used as a strategy to improve causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association ...
F. Hartwig, G. Davey Smith, J. Bowden
semanticscholar   +1 more source