Results 21 to 30 of about 143,068 (301)

Causal effects of physical activity on the risk of overall ovarian cancer: A Mendelian randomization study

Digital Health, 2023
Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang, Huanling Zhao, Jiahao Zhu, Minmin Jiang   +3 more
doaj   +1 more source

Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study : application to alcohol and cardiovascular traits [PDF]

, 2014
Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome.
Casas, Juan P., Leon, David A., Dudbridge, Frank, Whittaker, John C., Zuccolo, Luisa, Keating, Brendan J, Silverwood, Richard J., Holmes, Michael V, Smith, George Davey, Casas, Juan P, Silverwood, Richard J, Lawlor, Debbie A., Lawlor, Debbie A, Alcohol-ADH1B Consortium, Holmes, Michael V., Whittaker, John C, Leon, David A, Dale, Caroline E., Dale, Caroline E, Palmer, Tom M., Palmer, Tom, Keating, Brendan J.   +21 more
core   +1 more source

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
core   +1 more source

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

Emerging Themes in Epidemiology, 2009
Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried, Zhang Hongmei, Ogbuanu Ikechukwu U   +2 more
doaj   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj   +1 more source

Methodological Challenges in Mendelian Randomization [PDF]

Epidemiology, 2014
We give critical attention to the assumptions underlying Mendelian randomization analysis and their biological plausibility. Several scenarios violating the Mendelian randomization assumptions are described, including settings with inadequate phenotype definition, the setting of time-varying exposures, the presence of gene-environment interaction, the ...
Tyler J, VanderWeele, Eric J, Tchetgen Tchetgen, Marilyn, Cornelis, Peter, Kraft   +3 more
openaire   +2 more sources

Mendelian randomization in the bone field [PDF]

Bone, 2019
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement ...
Larsson, Susanna C, Michaëlsson, Karl, Burgess, Stephen   +2 more
openaire   +3 more sources

Understanding the Assumptions Underlying Mendelian Randomization [PDF]

European Journal of Human Genetics, 2021
With the rapidly increasing availability of large genetic data sets in recent years, Mendelian Randomization (MR) has quickly gained popularity as a novel secondary analysis method. Leveraging genetic variants as instrumental variables, MR can be used to estimate the causal effects of one phenotype on another even when experimental research is not ...
Christiaan de Leeuw, Jeanne Savage, Ioan Gabriel Bucur, Tom Heskes, Danielle Posthuma   +4 more
openaire   +3 more sources

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source