Results 21 to 30 of about 4,939,244 (349)

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Nature Genetics, 2018
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the ‘no horizontal pleiotropy’ assumption can cause severe bias in MR.
M. Verbanck, Chia-Yen Chen, B. Neale, R. Do   +3 more
semanticscholar   +1 more source

Methodological Challenges in Mendelian Randomization [PDF]

Epidemiology, 2014
We give critical attention to the assumptions underlying Mendelian randomization analysis and their biological plausibility. Several scenarios violating the Mendelian randomization assumptions are described, including settings with inadequate phenotype definition, the setting of time-varying exposures, the presence of gene-environment interaction, the ...
Tyler J, VanderWeele, Eric J, Tchetgen Tchetgen, Marilyn, Cornelis, Peter, Kraft   +3 more
openaire   +2 more sources

Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study : application to alcohol and cardiovascular traits [PDF]

, 2014
Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome.
Casas, Juan P., Leon, David A., Dudbridge, Frank, Whittaker, John C., Zuccolo, Luisa, Keating, Brendan J, Silverwood, Richard J., Holmes, Michael V, Smith, George Davey, Casas, Juan P, Silverwood, Richard J, Lawlor, Debbie A., Lawlor, Debbie A, Alcohol-ADH1B Consortium, Holmes, Michael V., Whittaker, John C, Leon, David A, Dale, Caroline E., Dale, Caroline E, Palmer, Tom M., Palmer, Tom, Keating, Brendan J.   +21 more
core   +1 more source

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

BMC Medicine, 2022
Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization
Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Geng-dong Chen, Dongxin Lin, D. Fan, Xiaoling Guo, Zheng-ping Liu   +8 more
semanticscholar   +1 more source

Mendelian randomization in the bone field [PDF]

Bone, 2019
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement ...
Larsson, Susanna C, Michaëlsson, Karl, Burgess, Stephen   +2 more
openaire   +3 more sources

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
core   +1 more source

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

Emerging Themes in Epidemiology, 2009
Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried, Zhang Hongmei, Ogbuanu Ikechukwu U   +2 more
doaj   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj   +1 more source

Statistical methods for Mendelian randomization in genome-wide association studies: A review

Computational and Structural Biotechnology Journal, 2022
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
doaj   +1 more source