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Mendelian Randomization Dictionary

, 2019
pdf of Lawlor DA, Wade K, et al. A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization ...
Professor Deborah A Lawlor
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Mendelian randomization

Nature Reviews Methods Primers, 2022
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson, M. Maria Glymour, Michael V. Holmes, Hyunseung Kang, Jean Morrison, Marcus R. Munafò, Tom Palmer, C. Mary Schooling, Chris Wallace, Qingyuan Zhao, George Davey Smith   +10 more
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Pleiotropy-robust Mendelian randomization [PDF]

International Journal of Epidemiology, 2016
Abstract Background The potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
van Kippersluis, Hans, Rietveld, Cornelius A   +1 more
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Mendelian Randomization [PDF]

JAMA, 2009
Despite several observational studies showing that lipoprotein(a), or Lp(a), is associated with myocardial infarction (MI)1, 2, only circumstantial evidence exists regarding the causal nature of this association. Observational epidemiological studies, even with a sound prospective design, can provide hints to disease pathogenesis when the effect size ...
George Thanassoulis, Christopher J. O’Donnell   +1 more
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Mendelian Randomization: Concepts and Scope [PDF]

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides a more robust understanding of the influence of these exposures on outcomes because germline ...
Richmond, Rebecca, Davey Smith, George
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Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
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Methodological Challenges in Mendelian Randomization [PDF]

Epidemiology, 2014
We give critical attention to the assumptions underlying Mendelian randomization analysis and their biological plausibility. Several scenarios violating the Mendelian randomization assumptions are described, including settings with inadequate phenotype definition, the setting of time-varying exposures, the presence of gene-environment interaction, the ...
Tyler J, VanderWeele, Eric J, Tchetgen Tchetgen, Marilyn, Cornelis, Peter, Kraft   +3 more
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Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. [PDF]

, 2007
BACKGROUND: In conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than vice versa, may invalidate causal interpretations of ...
Timpson, NJ, Timpson, Nic, Harbord, RM, Day, Ian, Timpson Nic, Lawlor, D, Smith George Davey, Smith, George Davey, Lawlor, Debbie A, Ebrahim, S, Harbord, Roger, Day Ian, Debbie A Lawlor, Nic Timpson, George Davey Smith, Ian Day, Shah Ebrahim, Roger Harbord, Lawlor Debbie A, Day, INM, Davey Smith, G, Ebrahim, Shah, Harbord Roger, Ebrahim Shah   +23 more
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The basic principles underlying Mendelian randomization.

, 2021
Fig 1A is the three assumptions for Mendelian randomization analysis. Fig 1B is the basic principles of bi-directional Mendelian randomization. SNP is the single nucleotide polymorphism and IV is the instrumental variable.
Zhenxing Tu (11576846), Hongquan Chen (4056973), Zhiguang Liu (174159), Jie Ding (73711)   +3 more
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Mendelian randomization in the bone field [PDF]

Bone, 2019
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement ...
Larsson, Susanna C, Michaëlsson, Karl, Burgess, Stephen   +2 more
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