Results 11 to 20 of about 4,939,244 (349)
Introduction to Mendelian randomization
Annals of Clinical EpidemiologyMendelian randomization (MR), i.e. instrumental variable analysis using genetic instruments, is an approach that incorporates population genetics to improve causal inference.
S. A. Yeung +3 more
semanticscholar +3 more sources
Mendelian Randomization: Concepts and Scope. [PDF]
Cold Spring Harbor Perspectives in Medicine, 2021 Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides
R. Richmond, G. Davey Smith
semanticscholar +4 more sources
Mendelian Randomization Dictionary
, 2019 pdf of Lawlor DA, Wade K, et al. A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization ...
Professor Deborah A Lawlor
openaire +2 more sources
Pleiotropy-robust Mendelian randomization [PDF]
International Journal of Epidemiology, 2016 Abstract Background The potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
van Kippersluis, Hans +1 more
openaire +3 more sources
Wellcome Open Research, 2020 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent +5 more
doaj +1 more source
Frontiers in Public Health, 2023 BackgroundObservational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding.
Tingting Wang +15 more
doaj +1 more source
Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies [PDF]
, 2018 BACKGROUND—Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.
Mendelian Randomization of Dairy Consumption Working Group
core +2 more sources
JAMA, 2009 Despite several observational studies showing that lipoprotein(a), or Lp(a), is associated with myocardial infarction (MI)1, 2, only circumstantial evidence exists regarding the causal nature of this association. Observational epidemiological studies, even with a sound prospective design, can provide hints to disease pathogenesis when the effect size ...
George Thanassoulis +1 more
openaire +1 more source
Digital Health, 2023 Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang +3 more
doaj +1 more source
Wellcome Open Research, 2023 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess +7 more
doaj +1 more source