Results 31 to 40 of about 4,939,244 (349)

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

Nature Communications, 2021
Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and ...
Liza Darrous, Ninon Mounier, Zoltán Kutalik   +2 more
doaj   +1 more source

Mendelian randomization for cardiovascular diseases: principles and applications

European Heart Journal, 2023
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous genetic variants associated with cardiometabolic traits and risk factors.
Susanna C. Larsson, A. Butterworth, Stephen Burgess   +2 more
semanticscholar   +1 more source

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. [PDF]

, 2007
BACKGROUND: In conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than vice versa, may invalidate causal interpretations of ...
Timpson, NJ, Timpson, Nic, Harbord, RM, Day, Ian, Timpson Nic, Lawlor, D, Smith George Davey, Smith, George Davey, Lawlor, Debbie A, Ebrahim, S, Harbord, Roger, Day Ian, Debbie A Lawlor, Nic Timpson, George Davey Smith, Ian Day, Shah Ebrahim, Roger Harbord, Lawlor Debbie A, Day, INM, Davey Smith, G, Ebrahim, Shah, Harbord Roger, Ebrahim Shah   +23 more
core   +1 more source

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Genetic Epidemiology, 2013
Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations.
S. Burgess, A. Butterworth, S. Thompson
semanticscholar   +1 more source

Understanding the Assumptions Underlying Mendelian Randomization [PDF]

European Journal of Human Genetics, 2021
With the rapidly increasing availability of large genetic data sets in recent years, Mendelian Randomization (MR) has quickly gained popularity as a novel secondary analysis method. Leveraging genetic variants as instrumental variables, MR can be used to estimate the causal effects of one phenotype on another even when experimental research is not ...
Christiaan de Leeuw, Jeanne Savage, Ioan Gabriel Bucur, Tom Heskes, Danielle Posthuma   +4 more
openaire   +3 more sources

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source

Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Nature Communications, 2022
Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing ...
Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson   +18 more
doaj   +1 more source

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

Human Molecular Genetics, 2014
Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects of modifiable exposures on disease outcomes.
G. Davey Smith, G. Hemani
semanticscholar   +1 more source

The next step in Mendelian randomization

eLife, 2023
Expanding a statistical approach called Mendelian randomization to include multiple variables may help researchers to identify new molecular causes of specific traits.
Matthias Weith, Andreas Beyer
openaire   +3 more sources

Using Mendelian Randomization to Improve the Design of Randomized Trials [PDF]

, 2021
Randomized controlled trials and Mendelian randomization studies are two study designs that provide randomized evidence in human biological and medical research.
Davey Smith, George, Ference, Brian, Holmes, Michael V   +2 more
core   +1 more source