Results 31 to 40 of about 143,068 (301)
Nature Communications, 2021 Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and ...
Liza Darrous +2 more
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The next step in Mendelian randomization
eLife, 2023 Expanding a statistical approach called Mendelian randomization to include multiple variables may help researchers to identify new molecular causes of specific traits.
Matthias Weith, Andreas Beyer
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Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. [PDF]
, 2007 BACKGROUND: In conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than vice versa, may invalidate causal interpretations of ...
Timpson, NJ +23 more
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Nature Communications, 2022 Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing ...
Lingyan Chen +18 more
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Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies [PDF]
, 2018 BACKGROUND—Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.
Mendelian Randomization of Dairy Consumption Working Group
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Multivariable Mendelian Randomization and Mediation [PDF]
Cold Spring Harbor Perspectives in Medicine, 2020 Mendelian randomization (MR) is the use of genetic variants associated with an exposure to estimate the causal effect of that exposure on an outcome. Mediation analysis is the method of decomposing the effects of an exposure on an outcome, which act directly, and those that act via mediating variables.
openaire +3 more sources
BMC Genomics, 2023 Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng +3 more
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Frontiers in Genetics, 2023 Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang +6 more
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Robust methods in Mendelian randomization [PDF]
, 2019 Mendelian randomization uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome using observational data.
core +2 more sources
Using Mendelian Randomization to Improve the Design of Randomized Trials [PDF]
, 2021 Randomized controlled trials and Mendelian randomization studies are two study designs that provide randomized evidence in human biological and medical research.
Davey Smith, George +2 more
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