Results 31 to 40 of about 45,355 (266)

Rheumatoid arthritis and risk of lung diseases in East Asians and Europeans: Evidence from a Mendelian randomization study

SAGE Open Medicine
Background: Rheumatoid arthritis might increase the risk of lung diseases, such as interstitial lung disease and lung cancer. However, the causal relationships remained unclear.
Shengkai Zhang, Xiang Huang, Meiying Huang, Xinhan Peng, Qiuye Cao, Yi Lan   +5 more
doaj   +1 more source

Causal relationship among obesity and body fat distribution and epilepsy subtypes

Frontiers in Neurology, 2022
ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality.
Kaiping Zhou, Huan Yang, Ruomeng Chen, Weiping Wang, Zhenzhen Qu   +4 more
doaj   +1 more source

Introduction to Mendelian randomization

Annals of Clinical Epidemiology
Mendelian randomization (MR), i.e. instrumental variable analysis using genetic instruments, is an approach that incorporates population genetics to improve causal inference. Given that genetics are randomly allocated at conception, this resembles the randomization process in randomized controlled trials and hence is more resistant to unobserved ...
Yeung, Shiu Lun Au, Luo, Shan, Iwagami, Masao, Goto, Atsushi   +3 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Smoking and stroke: A mendelian randomization study [PDF]

Annals of Neurology, 2019
We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630 noncases, and 1,545 cases of intracerebral hemorrhage and 1,481 noncases.
Larsson, Susanna C, Burgess, Stephen, Michaëlsson, Karl   +2 more
openaire   +4 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis

Journal of International Medical Research
Objective Observational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.
Shuai Zhou, Peiwen Zhou, Tianshi Yang, Junzhuo Si, Wenyan An, Yanfang Jiang   +5 more
doaj   +1 more source

Recent Developments in Mendelian Randomization Studies [PDF]

Current Epidemiology Reports, 2017
Mendelian randomization (MR) is a strategy for evaluating causality in observational epidemiological studies. MR exploits the fact that genotypes are not generally susceptible to reverse causation and confounding, due to their fixed nature and Mendel's First and Second Laws of Inheritance.
Zheng, Jie, Baird, Denis, Borges, Carolina, Bowden, Jack, Hemani, Gibran, Haycock, Philip, Evans, David M, Davey Smith, George   +7 more
openaire   +5 more sources

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

The causal relationship between obesity and IgA nephropathy: a Mendelian randomization study

Linchuang shenzangbing zazhi
ObjectiveTo explore the potential causal relationship between obesity and IgA nephropathy through Mendelian randomization. MethodsSummary-level data from genome-wide association studies of obesity-related shapes (body mass index, percentage body fat ...
Peng-tao Dong, Zheng Wang, Xiao-yu Li, Qing Zhang   +3 more
doaj   +1 more source