Results 91 to 100 of about 4,939,244 (349)

Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study

SAGE Open Medicine
Objective: Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal.
Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao   +4 more
doaj   +1 more source

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score [PDF]

Annals of Statistics, 2018
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science.
Qingyuan Zhao, Jingshu Wang, G. Hemani, J. Bowden, Dylan S. Small   +4 more
semanticscholar   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Evaluating the causal relationship of Levo-carnitine and risk of schizophrenia: a bidirectional two-sample mendelian randomization study

BMC Psychiatry
Background Schizophrenia is a debilitating mental disorder affecting about 1% of the global population, characterized by significant cognitive impairments and a strong hereditary component.
Haoyuan Qiu, Zicheng Zhong, Tianxing Wu, Haoran Hu, Meijuan Zhou, Zhijun Feng   +5 more
doaj   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Concept of Mendelian randomization.

, 2015
Concept of Mendelian randomization.
Albert Hofman (107303), Oscar H. Franco (303354), Marte C. Liefaard (765482), Anna Vitezova (733786), Abbas Dehghan (174878), Jessica C. Kiefte-de Jong (591843), Symen Ligthart (701678), M. Carola Zillikens (152896), André G. Uitterlinden (2213413)   +8 more
core   +1 more source

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease.

, 2023
An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking.
Squassina, A., Royo, J.L., Sorbi, S., Scarmeas, N., Rujescu, D., Porcel, L.M., Nicolas, G., Galimberti, D., Mecocci, P., Soininen, H., Andreassen, O.A., Ruiz, A., Graff, C., Grenier-Boley, B., Kuulasmaa, T., Düzel, E., Grünblatt, E., Borroni, B., de Mendonça, A., Jürgen, D., Boada, M., Grimmer, T., Mehrabian, S., Tegos, T., Pérez-Tur, J., Schneider, A., Daniele, A., Moebus, S., Rodriguez-Rodriguez, E., Tremolizzo, L., Giedraitis, V., Ramirez, A., Clarimon, J., Lambert, J.C., de Rojas, I., Spalletta, G., Riedel-Heller, S., Van Duijn, C., Hausner, L., Kehoe, P., Solfrizzi, V., Parveen, K., Ingelsson, M., Seripa, D., Deleuze, J.F., Masullo, C., Frikke-Schmidt, R., Sánchez-Valle, R., Dufouil, C., Williams, J., Sleegers, K., García-González, P., Pastor, P., García-Alberca, J.M., Caffarra, P., Jessen, F., Bellenguez, C., Hanon, O., Luo, J., Nicolas, A., Heilmann-Heimbach, S., Mir, P., Bacq-Daian, D., Rainero, I., Álvarez, V., Rossi, G., Wiltfang, J., Moreno, F., Castillo, A., Papenberg, G., Tsolaki, M., Debette, S., Piñol-Ripoll, G., Amouyel, P., Real, L.M., Thomassen, J.Q., Scherbaum, N., Hort, J., Pasquier, F., Vyhnalek, M., Nacmias, B., Arosio, B., Benussi, L., Hiltunen, M., Sims, R., Peters, O., Boland, A., Popp, J., Parnetti, L., Küçükali, F., Dichgans, M., Puerta, R., van der Flier, W., Bullido, M.J., van der Lee, S., Sánchez-Juan, P.   +95 more
core   +1 more source

Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption

bioRxiv, 2018
Background Two-sample summary data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for assessing causality in epidemiology.
J. Bowden, F. Del Greco M, C. Minelli, Qingyuan Zhao, D. Lawlor, N. Sheehan, J. Thompson, G. Davey Smith   +7 more
semanticscholar   +1 more source

The challenge of Mendelian randomization approach [PDF]

Current Medical Research and Opinion, 2017
This review deals with methodological problems in current evidence that suggest links between gout and adverse cardiovascular (CV) outcomes and renal disease, and presents a recently adopted approach aimed at overcoming such drawbacks. The review aims to provide more reliable answers regarding the role of uric acid in the pathogenesis and progression ...
openaire   +2 more sources

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source