Results 101 to 110 of about 143,068 (301)

Mendelian randomization Asthma exposure pain outcome.

, 2023
Mendelian randomization Asthma exposure pain outcome.
James A. Perry (10515389), Siobhan M. Schabrun (11929656), Susan G. Dorsey (11780093), Kathryn Ward (17174753), Evelina Mocci (374296), Seth A. Ament (9427801), Cynthia Renn (17174756), Angela Starkweather (10581244), Laura S. Stone (9392671)   +8 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Challenges and future directions for Mendelian randomization

Mendelian randomization has evolved from a niche methodology to a widely adopted research approach. In this Perspective, we briefly present a bibliometric analysis of the Mendelian randomization literature to inform a discussion of how Mendelian ...
Badini, Isabella, Davies, Neil M, Sanderson, Eleanor, Nho, Ju-Woo, Walker, Venexia, Levin, Michael G, Yuan, Shuai, Hemani, Gibran, Dolce, Julia, Mahida, Karina J, Damrauer, Scott M, Pingault, Jean-Baptiste   +11 more
core   +3 more sources

Immunocytes do not mediate food intake and the causal relationship with allergic rhinitis: a comprehensive Mendelian randomization

Frontiers in Nutrition
BackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing ...
Zhi-qiang Zhang, Jing-yang Li, You-wei Bao, Yu-Qi Song, Dong-xu Song, Cheng Wang, Xin-hua Zhu   +6 more
doaj   +1 more source

Mendelian randomization results of weighted median.

, 2023
Mendelian randomization results of weighted median.
Jianlin Zuo (13019001), Lanlan Chen (4860436), Haitao Li (305080), Hongqun Yang (11451091), Zhuangzhuang Ma (5220842), Chaofeng Yuan (17441259)   +5 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study

, 2018
Chelsea A Isom,1 Martha J Shrubsole,2,3 Qiuyin Cai,2 Walter E Smalley,4,5 Reid M Ness,5 Wei Zheng,2,3 Harvey J Murff3,6 1Department of General Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; 2Division of Epidemiology, Vanderbilt ...
Murff HJ, Cai Q, Isom CA, Shrubsole MJ, Smalley WE, Ness RM, Zheng W   +6 more
core  

Sleep disturbances and heart failure: observational study and Mendelian randomization study

Introduction Sleep disturbances are prevalent among patients with heart failure (HF) and may trigger acute exacerbations of the condition. However, the causal relationship between sleep disturbances and HF remains uncertain.
Junwen Wang, Ziyi Sun, Xufeng Chen, Yuyang Ye, Yong Peng, Xinru Hu, Yi Zhong   +6 more
core   +1 more source

IDENTIFYING CAUSAL GENETIC VARIANTS IN PSYCHIATRIC DISORDERS USING SUMMARY DATA BASED MENDELIAN RANDOMIZATION

, 2019
IDENTIFYING CAUSAL GENETIC VARIANTS IN PSYCHIATRIC DISORDERS USING SUMMARY DATA BASED MENDELIAN ...
Straub, Richard E., Pergola, Giulio, Chen, Qiang, Kleinman, Joel E., Sadashivaiah, Vijay, Jaffe, Andrew E., Shin, Joo Heon, Radulescu, Eugenia, Hyde, Thomas M., Weinberger, Daniel R.   +9 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source