Results 151 to 160 of about 95,337 (328)

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

, 2020
Jing Chen, Jonas Bačelis, Pol Solé-Navais, Amit Kumar Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Debbie A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang   +17 more
openalex   +1 more source

Association between cannabis use with urological cancers: A population‐based cohort study and a mendelian randomization study in the UK biobank

, 2022
Jingyi Huang, Da Huang, Xiaohao Ruan, Jinlun Huang, Danfeng Xu, Susan Heavey, Jonathan Olivier, Rong Na   +7 more
openalex   +1 more source

Integrated Roles of Systemic Diseases and Serum Biomarkers in the Incidence of Age‐Related Macular Degeneration: The UK Biobank Study

Medicine Bulletin, EarlyView.
ABSTRACT Background To evaluate the associations of systemic diseases with AMD incidence and explore whether polygenic risk score (PRS) for AMD influences these associations. To assess the impacts of polymorbidities and serum biomarkers on AMD risk. Methods This prospective study of 471156 AMD‐free UK Biobank participants assessed systemic diseases ...
Jun Yu, Yuzhou Zhang, Mary Ho, Ka Wai Kam, Shi Song Rong, Alvin L. Young, Chi Pui Pang, Clement C. Tham, Jason C. Yam, Li Jia Chen   +9 more
wiley   +1 more source

Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study

Drugs - Real World Outcomes
Background The relationship between antidepressants, depression, and the incidence of postpartum hemorrhage (PPH) has been reported in observational studies, but the causal link between these factors remains unknown.
Zhenzhen Chen, Qingqing Lv, Shiteng Lin, Wanlong Lin, Wei Zhuang   +4 more
doaj   +1 more source

Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study

Frontiers in Cardiovascular Medicine
BackgroundObservational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this association reflects a causal association.
Chennan Liu, Chennan Liu, Laicheng Wang, Mei Lin, Mei Lin, Jing You, Jing You, Xuan Zheng, Xuan Zheng, Ailing Wang, Ailing Wang, Yunchai Lin, Yunchai Lin, Feng Peng, Feng Peng, Dan Hu   +15 more
doaj   +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Deviation From Genetically Predicted BMI and All‐Cause Mortality: A Cohort Study in the UK Biobank

Obesity, EarlyView.
ABSTRACT Objective The relation between genetically predicted BMI (gBMI) and actual BMI may have health effects. This study examines the relationship between deviations from gBMI and all‐cause mortality in 208,146 UK Biobank participants. Methods We derived gBMI from polygenic risk scores, with deviations calculated as the difference between observed ...
Nuno R. Zilhao, Jie Zhang, Dorret I. Boomsma, Thorkild I. A. Sørensen, Christina C. Dahm   +4 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

, 2016
Philip Haycock, Stephen Burgess, Kaitlin H. Wade, Jack Bowden, Caroline L. Relton, George Davey Smith   +5 more
openalex   +1 more source