Results 151 to 160 of about 4,310,301 (302)

Evaluation of Moderate Alcohol Use and Cognitive Function Among Men Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study [PDF]

, 2012
Shiu Lun Au Yeung, C Q Jiang, Kar Keung Cheng, Bohong Liu, W. S. Zhang, TH Lam, GM Leung, C. Mary Schooling   +7 more
openalex   +1 more source

Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

Movement Disorders, EarlyView.
Abstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Camila C. Piccinin, Saar Anis, Jeryl Ritzi T. Yu, Philippe A. Salles, Henry Mauricio Chaparro‐Solano, Avery Kundrick, Shelley Ivary, James Y. Liao, Sean J. Nagel, Ignacio F. Mata   +9 more
wiley   +1 more source

The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies

The Clinical Respiratory Journal, Volume 16, Issue 12, Page 777-792, December 2022., 2022
The risk of death in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46–1.57; I2: 86.14%). Abstract Introduction The aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe ...
Maryam Afraie, Pardis Mohammadzedeh, Mobin Azami, Sorour Khateri, Kamran Zamani, Farhad Moradpour, Yousef Moradi   +6 more
wiley   +1 more source

Gut microbiota in combination with blood metabolites reveals characteristics of the disease cluster of coronary artery disease and cognitive impairment: a Mendelian randomization study

Frontiers in Immunology
BackgroundThe coexistence of coronary artery disease (CAD) and cognitive impairment has become a common clinical phenomenon. However, there is currently limited research on the etiology of this disease cluster, discovery of biomarkers, and identification
Shihan Xu, Shihan Xu, Shihan Xu, Yanfei Liu, Yanfei Liu, Yanfei Liu, Qing Wang, Qing Wang, Qing Wang, Fenglan Liu, Yanfang Xian, Fengqin Xu, Fengqin Xu, Fengqin Xu, Fengqin Xu, Yue Liu, Yue Liu   +16 more
doaj   +1 more source

The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies [PDF]

, 2012
Brandon L. Pierce, Tyler J. VanderWeele
openalex   +1 more source

Long‐Read Sequencing: The Third Generation of Diagnostic Testing for Dystonia

Movement Disorders, EarlyView.
Abstract Long‐read sequencing methodologies provide powerful capacity to identify all types of genomic variations in a single test. Long‐read platforms such as Oxford Nanopore and PacBio have the potential to revolutionize molecular diagnostics by reaching unparalleled accuracies in genetic discovery and long‐range phasing.
Thomas Wirth, Kishore R. Kumar, Michael Zech   +2 more
wiley   +1 more source

Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses

The Journal of Nutrition, Health and Aging
Background: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases.
Shuai-Kang Wang, Qi-Jun Wang, Xuan Zhao, Peng Wang, Xiang-Yu Li, Wei Wang, Shi-Bao Lu   +6 more
doaj  

Exploring the causal links between cigarette smoking, alcohol consumption, and aneurysmal subarachnoid hemorrhage: a two-sample Mendelian randomization analysis

Frontiers in Nutrition
BackgroundAneurysmal subarachnoid hemorrhage (aSAH) represents a critical health concern characterized by elevated mortality and morbidity rates. Although both genetic predisposition and lifestyle choices influence aSAH susceptibility, understanding the ...
Heng Lin, Yanqing Yin, Jie Li, Siwei Liu, Xiaoao Long, Zhuangbin Liao   +5 more
doaj   +1 more source

Associations Between Lipids and Lipid‐Lowering Drug Target Genes and Osteomyelitis: A Mendelian Randomization Analysis

Medicine Advances, EarlyView.
In this study, we identified several SNPs in PCSK9 as genetic tools to comprehensively assess the influential role of PCSK9 in CHD, CRP, and osteomyelitis. PCSK9 is associated with a lower risk of osteomyelitis, and PCSK9 is also associated with a reduction in CRP concentrations. Our study supports the notion that WC may be a potential mediator between
Zhiyi Zhou, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Wanzhe Liao, Yahan Li, Linghui Liu, Ziyuan Lu   +8 more
wiley   +1 more source

Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics

Frontiers in Immunology
BackgroundThe current landscape of acne therapeutics is notably lacking in targeted treatments, highlighting a critical need for the discovery of new drug targets to improve treatment outcomes.ObjectivesThis study aims to investigate the connections ...
Sui Deng, Rui Mao, Yifeng He
doaj   +1 more source