Results 171 to 180 of about 95,337 (328)

Depression as a causal factor in obstructive sleep apnea: An analysis based on the NHANES 2005–2008

Sleep Research, EarlyView.
Abstract Background Depression and obstructive sleep apnea (OSA) have complex and incompletely understood pathophysiological links. Our study used National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2008 to elucidate their associations.
Guo‐qiang Song, Hua‐man Wu, Yi‐meng Duan, Guo‐qiang Hu   +3 more
wiley   +1 more source

Investigating the shared genetic architecture between obstructive sleep apnea and sleep‐related traits

Sleep Research, EarlyView.
Abstract Background Despite a strong link between obstructive sleep apnea (OSA) and sleep traits, the shared genetic architecture remains unclear. This study aims to explore the shared genetic basis and bidirectional causal between OSA and sleep traits.
Sizhi Ai, Hengyu Zhang, Jiaqi Liu, Zhen Song, Zaiming Liao, Guohua Li, Shujuan Yin, Binhe Yu, Sheng Guo, Ruizhi Zhang, Caihui Cha, Yingjun Zheng   +11 more
wiley   +1 more source

Commentary: Role of vitamin D in disease through the lens of Mendelian randomization—Evidence from Mendelian randomization challenges the benefits of vitamin D supplementation for disease prevention [PDF]

, 2019
Despoina Manousaki, J. Brent Richards
openalex   +1 more source

Real‐World Molecular Testing in European Early‐Onset Colorectal Cancer

United European Gastroenterology Journal, EarlyView.
ABSTRACT Purpose The global incidence and mortality of early‐age onset colorectal cancer (EOCRC, or CRC diagnosed under 50 years) has increased in recent decades. High‐risk surveillance and personalised oncological treatment may improve patients' outcomes.
Penelope V. Edwards, Kussai Giuma Ali Eloussta, Andrew Latchford, Omar Faiz, Huw Thomas, Filomena Liccardo, Nikhil Pawa, Robert Hüneburg, Jacob Nattermann, Andrew George, Francesc Balaguer, Marc Martí, Antonino Spinelli, Caterina Foppa, Noel F. F. C. de Miranda, Irene López, Elena Hurtado, Fernando Jiménez, Marta Jiménez‐Toscano, Edurne Álvaro, Gonzalo Sanz, Araceli Ballestero, José A. Rueda, Cristina Viyuela, Lorena Brandáriz, Rosario Vidal‐Tocino, Damián García‐Olmo, Carlos Pastor, Rogelio González‐Sarmiento, Andreana N. Holowatyj, Terri McVeigh, José Perea, Kevin J. Monahan, On behalf of Collaborators GEOCODE and SECOC Consortia   +33 more
wiley   +1 more source

Editorial: Mendelian Randomization: Approach and Applications [PDF]

Frontiers in Genetics, 2021
Guo-Liang Wu, Yao-Zhong Liu, Lei Zhang
openaire   +3 more sources

Development of a prognostic nomogram and genetic insights for prostate cancer patients with secondary primary malignancies: A SEER retrospective cohort study and Mendelian randomization analysis

UroPrecision, EarlyView.
Abstract Background Prostate cancer (PCa) patients are at risk of developing second primary malignancies (SPMs), which can significantly shorten their survival. Understanding the risk of SPMs and associated factors is crucial to the optimization of patient follow‐up.
Qi Zhang, Lufan Liang, Ziyu Liu, Ziyang Yang, Jiahao Cheng, Xuan Li, Yueting Huang, Weisi Chen, Jiazhen Yin, Ligong Chen, Zhang Cao, Di Gu   +11 more
wiley   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Association of Physical Activity with Asthma and Chronic Obstructive Pulmonary Disease and Mediation of Frailty: Mendelian Randomization Analyses

International Journal of COPD
Nanxin Chen,1 Xuejie Si,2 Jun Wang,2 Wenjing Chen2 1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The ...
Chen N, Si X, Wang J, Chen W
doaj  

The causal relationship between snoring and benign prostatic hyperplasia: A Mendelian randomization study

, 2023
Kai Ma, Song Pan, Luchen Yang, Qiang Dong   +3 more
openalex   +1 more source