Results 201 to 210 of about 95,337 (328)

RETRACTED: No causal association between atopic dermatitis and COVID‐19 outcomes: A Mendelian randomization study [PDF]

Jin Chen, Yuwen Li
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Mendelian randomization of autoimmune hepatitis and cardiovascular diseases. [PDF]

Am Heart J Plus
Tang F, Zhao TJ, Dong PW, Sun KD, Sun XB, Wang Q.   +5 more
europepmc   +1 more source

Investigating the shared genetic architecture between primary sclerosing cholangitis and inflammatory bowel diseases: a Mendelian randomization study [PDF]

Xuan Dong, Lili Gong, Mei‐Zhu Hong, Jin‐Shui Pan   +3 more
openalex   +1 more source

Additional file 2 of Causal effects of serum lipid biomarkers on early age-related macular degeneration using Mendelian randomization

, 2023
Fenfen Li, Yuqin Wang, Lishuang Chen, Chong Chen, Qi Chen, Lue Xiang, Feng-Qin Rao, Lijun Shen, Qinxiang Zheng, Quanyong Yi, Xiu‐Feng Huang   +10 more
openalex   +1 more source

A century of theories of balancing selection

Biological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi Li Richter, Iain R. Moodie, Sofie Nilén, Colin Olito, Erik I. Svensson, Peter Czuppon, Tim Connallon   +10 more
wiley   +1 more source

Mendelian Randomization and Infection: Pitfalls and Promises. [PDF]

J Infect Dis
Hamilton F, Butler-Laporte G, Davey Smith G.   +2 more
europepmc   +1 more source

Brief description of Mendelian randomized studies

Revista Española de Enfermedades Digestivas
Mendelian randomization (MR) offers a more rigorous framework than traditional observational studies by using genetic variants to assess causal relationships. Three critical assumptions are necessary for MR validity: relevance, independence, and exclusion restriction. These assumptions ensure that the genetic variants accurately reflect the risk factor'
openaire   +2 more sources

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

Cancer Science, EarlyView.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo, JianGuo Xu, ZhiYuan Wang, XiaoFang Wang, YangHao Wang, Yu Zhang, FangFang Li, Hui Fang, XiaoYun Huang, MuYe Li, XiaoJuan Liu, JiHong Tang, PeiYang Fan, GuoJing Zhao, YongWen He, Li Bian   +15 more
wiley   +1 more source

The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates? [PDF]

AJE Adv
Woolf B, Burgess S.
europepmc   +1 more source