Results 211 to 220 of about 51,589 (295)

Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors

, 2015
Stephen Burgess, Adam S. Butterworth, John R. Thompson   +2 more
openalex   +1 more source

The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study [PDF]

, 2016
Robert Carreras‐Torres, Philip Haycock, Caroline L. Relton, Richard M. Martin, George Davey Smith, Peter Kraft, Chi Gao, Shelley S. Tworoger, Loı̈c Le Marchand, Lynne R. Wilkens, Sungshim L. Park, Christopher A. Haiman, John K. Field, Michael Davies, Michael W. Marcus, Geoffrey Liu, Neil E. Caporaso, David C. Christiani, Yongyue Wei, Chu Chen, Jennifer A. Doherty, Gianluca Severi, Gary E. Goodman, Rayjean J. Hung, Christopher I. Amos, James McKay, Mattias Johansson, Paul Brennan   +27 more
openalex   +1 more source

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

Mendelian randomization analysis of modifiable risk factors for breast cancer. [PDF]

Discov Oncol
Ousmane D, Liu J, Liu Z, Zhou Z, Liu L, Wang J.   +5 more
europepmc   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study. [PDF]

Clin Cosmet Investig Dermatol
Ge C, Wang Y, Zhao X, Hao J, Zhang J, Lu M, Li C, Feng J, Zhang Q.   +8 more
europepmc   +1 more source

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer [PDF]

, 2016
Caroline J. Bull, James Yarmolinsky, Kaitlin H. Wade   +2 more
openalex   +1 more source

A Recursive Model Approach to Include Epigenetic Effects in Genetic Evaluations Using Simulated DNA Methylation Effects

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The advancement of epigenetics has highlighted DNA methylation as an intermediate‐omic influencing gene regulation and phenotypic expression. With emerging technologies enabling the large‐scale and affordable capture of methylation data, there is growing interest in integrating this information into genetic evaluation models for animal ...
Adrián López‐Catalina, Mohamed Ragab, Antonio Reverter, Oscar González‐Recio   +3 more
wiley   +1 more source

Plasma Homocysteine Levels and Intracerebral Hemorrhage: A Mendelian Randomization Analysis. [PDF]

Cureus
Chen S, Guo X, He Y, Wang Y.
europepmc   +1 more source

Genetically Predicted Testosterone and Systemic Inflammation in Men: A Separate-Sample Mendelian Randomization Analysis in Older Chinese Men

, 2015
Jie Zhao, Chaoqiang Jiang, TH Lam, Bin Liu, Kar Keung Cheng, Lin Xu, Shiu Lun Au Yeung, Weisen Zhang, GM Leung, C. Mary Schooling   +9 more
openalex   +2 more sources