Results 41 to 50 of about 51,589 (295)

The causal relationship between obesity and IgA nephropathy: a Mendelian randomization study

Linchuang shenzangbing zazhi
ObjectiveTo explore the potential causal relationship between obesity and IgA nephropathy through Mendelian randomization. MethodsSummary-level data from genome-wide association studies of obesity-related shapes (body mass index, percentage body fat ...
Peng-tao Dong, Zheng Wang, Xiao-yu Li, Qing Zhang   +3 more
doaj   +1 more source

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants

BMC Medicine, 2022
Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs).
Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani, Deborah A. Lawlor   +7 more
doaj   +1 more source

Causal effects of gut microbiome on hypertension: a Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to ...
Gang He, Yu Cao, Houzhao Wang, Houzhao Wang, Xiaoying Lv   +4 more
doaj   +1 more source

The challenge of Mendelian randomization approach [PDF]

Current Medical Research and Opinion, 2017
This review deals with methodological problems in current evidence that suggest links between gout and adverse cardiovascular (CV) outcomes and renal disease, and presents a recently adopted approach aimed at overcoming such drawbacks. The review aims to provide more reliable answers regarding the role of uric acid in the pathogenesis and progression ...
openaire   +2 more sources

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj  

Mendelian randomization in nutritional epidemiology [PDF]

Nutrition Reviews, 2009
Nutritional epidemiology aims to identify dietary and lifestyle causes for human diseases. Causality inference in nutritional epidemiology is largely based on evidence from studies of observational design, and may be distorted by unmeasured or residual confounding and reverse causation.
openaire   +3 more sources

Recent Developments in Mendelian Randomization Studies [PDF]

Current Epidemiology Reports, 2017
Mendelian randomization (MR) is a strategy for evaluating causality in observational epidemiological studies. MR exploits the fact that genotypes are not generally susceptible to reverse causation and confounding, due to their fixed nature and Mendel's First and Second Laws of Inheritance.
Gibran Hemani, Jack Bowden, Jie Zheng, George Davey Smith, Denis Baird, Maria Carolina Borges, David M. Evans, David M. Evans, Philip C Haycock   +8 more
openaire   +5 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study

SAGE Open Medicine
Objective: Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal.
Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao   +4 more
doaj   +1 more source