Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies [PDF]
Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by ...
A Hruby +82 more
core +6 more sources
Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes [PDF]
Mortality rate is increased in type 2 diabetes (T2D). Low vitamin D levels are associated with increased mortality risk in T2D. In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588 ...
Alessi, Elena +36 more
core +1 more source
Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar +3 more
doaj +1 more source
Genome-wide association study identifies common and low-frequency variants at the AMHgene locus that strongly predict serum AMH levels in males [PDF]
Anti-Müllerian hormone (AMH) is an essential messenger of sexual differentiation in the foetus and is an emerging biomarker of postnatal reproductive function in females.
Day, Felix R. +5 more
core +1 more source
Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children. [PDF]
BACKGROUND: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes ...
Amaku, Marcos +4 more
core +2 more sources
Biomarkers and type 2 diabetes [PDF]
This is the author accepted manuscript. The final version is available from Bioscientifica via http://dx.doi.org/10.1530/EC-15-0087Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations.
Abbasi, Ali
core +4 more sources
Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. [PDF]
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the
Burgess, Stephen, Thompson, Simon G
core +5 more sources
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? [PDF]
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent ...
Abbas +173 more
core +2 more sources
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan +9 more
doaj +1 more source
Serum resistin is causally related to mortality risk in patients with type 2 diabetes: Preliminary evidences from genetic data [PDF]
Resistin has been firmly associated with all-cause mortality. We investigated, whether, in patients with type 2 diabetes (T2D), this association is sustained by a cause-effect relationship.
Cignarelli, Mauro +9 more
core +1 more source

