Results 71 to 80 of about 51,589 (295)

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data revealed causal relationship between heavy cigarette dependence and Barrett’s esophagus

SAGE Open Medicine
Background: The association between smoking dependence and the risk of developing Barrett’s esophagus remains unclear. This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using ...
Zhou An, Meichun Zeng, Xianhua Wang
doaj   +1 more source

Immunocytes do not mediate food intake and the causal relationship with allergic rhinitis: a comprehensive Mendelian randomization

Frontiers in Nutrition
BackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing ...
Zhi-qiang Zhang, Jing-yang Li, You-wei Bao, Yu-Qi Song, Dong-xu Song, Cheng Wang, Xin-hua Zhu   +6 more
doaj   +1 more source

Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where TNF or IL‐17 Blockade may have a Therapeutic Role

Arthritis &Rheumatology, Accepted Article.
Background Polymyalgia rheumatica (PMR) is an age‐related inflammatory disease with shoulder‐hip girdle involvement. Magnetic resonance imaging (MRI) reveals extracapsular/entheseal soft tissue involvements in both PMR and spondyloarthritis (SpA) with sacroiliac joint and peri‐entheseal spinal bone marrow oedema (BMO) being characteristic of SpA ...
Kerem Abacar, Gabriele De Marco, Jake Weddell, Katya Meridor, Tom Macleod, Andrew Scarsbrook, Kulveer Mankia, Edward Vital, Andrew Barr, Colin Pease, Helena Marzo‐Ortega, Sarah L. Mackie, Dennis McGonagle   +12 more
wiley   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj  

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study

Hereditas
Background The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as ...
Chongcheng Xi, Jie Zhang, Haihui Liu, Sian Tao, Ying Xie, Jibin Liu, Changqing Tong, Dong Tian, Hua Ye, Xiaobo Zhang   +9 more
doaj   +1 more source

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish

Developmental Dynamics, EarlyView.
Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan, Travis K. Johnson, Zachary Di Pastena, Jarrad N. Fuller, Lee B. Miles, Sebastian Dworkin   +5 more
wiley   +1 more source

Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk

Frontiers in Genetics
Background: Colorectal cancer (CRC) is a malignancy with high incidence and mortality rates globally, categorized into left-sided and right-sided CRC, each exhibiting significant differences in molecular characteristics, clinical manifestations, and ...
Zhihao Shang, Zhihao Shang, Songyang Xi, Songyang Xi, Songyang Xi, Yueyang Lai, Yueyang Lai, Haibo Cheng, Haibo Cheng   +8 more
doaj   +1 more source