Results 71 to 80 of about 4,310,301 (302)

Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain

Advanced Science, EarlyView.
This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li, Qing Ma, Jie Zhang, Rui‐Ying Yin, Jia You, Qi‐Zheng Hao, Xin‐Rui Wu, Ju‐Jiao Kang, Lin‐Bo Wang, Yue‐Ting Deng, Yu‐Zhu Li, Chun Shen, Bang‐Sheng Wu, Jian‐Feng Feng, Yi‐Heng Tu, Xiao Xiao, Jin‐Tai Yu, Wei Cheng   +17 more
wiley   +1 more source

Risk factors of systemic lupus erythematosus: an overview of systematic reviews and Mendelian randomization studies

Advances in Rheumatology, 2023
Background The etiology of systemic lupus erythematosus is complex and incurable. A large number of systematic reviews have studied the risk factors of it.
Xin-Yu Xiao, Qian Chen, Yun-Zhou Shi, Li-Wen Li, Can Hua, Hui Zheng   +5 more
doaj   +1 more source

Depression and 24 gastrointestinal diseases: a Mendelian randomization study

Translational Psychiatry, 2023
The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted Mendelian randomization (MR) analyses to systematically explore the associations of depression with 24 gastrointestinal diseases.
Xixian Ruan, Jie Chen, Yuhao Sun, Yao Zhang, Jianhui Zhao, Xiao-Yang Wang, Xia Li, S. Yuan, S. Larsson   +8 more
semanticscholar   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Evaluating the potential role of pleiotropy in Mendelian randomization studies

Human Molecular Genetics, 2018
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ...
G. Hemani, J. Bowden, G. Davey Smith
semanticscholar   +1 more source

Dietary factors and risk for asthma: A Mendelian randomization analysis

Frontiers in Immunology, 2023
Background Previous research has found a link between dietary factors and asthma. However, few studies have analyzed the relationship between dietary factors and asthma using Mendelian randomization.
Wenwen Yang, Yanjiang Yang, Li He, M. Zhang, Shuo Sun, Feng Wang, Biao Han   +6 more
semanticscholar   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source

Association of demographic and clinical factors with risk of acute pancreatitis: An exposure‐wide Mendelian randomization study

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
The incidence of acute pancreatitis is increasing over years especially in western countries, but the etiologies of acute pancreatitis have not been well understood. And it is unclear whether the reported possible risk factors are real causes of acute pancreatitis.
Qiu‐Yi Tang, Qi Yang, Xian‐Qiang Yu, Yu‐Xiu Liu, Zhi‐Hui Tong, Bai‐Qiang Li, Ya‐Ting Chen, Evan Yi‐Wen Yu, Wei‐Qin Li   +8 more
wiley   +1 more source

Endocrine and metabolic factors and the risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

Frontiers in Endocrinology
Background Previous observational studies have investigated the association between endocrine and metabolic factors and idiopathic pulmonary fibrosis (IPF), yet have produced inconsistent results.
Yan Jiang, Rumeng Chen, Shuling Xu, Yining Ding, Mengling Zhang, Meihua Bao, Binsheng He, Sen Li   +7 more
semanticscholar   +1 more source