Results 81 to 90 of about 51,589 (295)
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source
Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study
ESC Heart Failure, EarlyView.Abstract Aims Numerous observational studies have reported an association between calcific aortic valve stenosis (CAVS) and an increased risk of other cardiovascular diseases (CVDs). However, the potential causal association is uncertain. Methods and results A bidirectional Mendelian randomization (MR) analysis was performed to confirm the causal ...
Dihui Cai, Jianhui Liu
wiley +1 more source
Fulfilling the promise of Mendelian randomization [PDF]
, 2015 Many important questions in medicine involve questions about causality, For example, do low levels of high-density lipoproteins (HDL) cause heart disease? Does high body mass index (BMI) cause type 2 diabetes? Or are these traits simply correlated in the population for other reasons?
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Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundMendelian randomization is believed to attenuate the biases inherent in observational studies, yet a meta-analysis of Mendelian randomization studies in osteoporosis has not been conducted thus far.
Wenhao Ji +11 more
doaj +1 more source
Commentary: Mendelian randomization and gene-environment interaction [PDF]
, 2004 Paul Brennan
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Commentary: Fibrinogen and coronary heart disease—test of causality by ‘Mendelian’ randomization by Keavney et al. [PDF]
, 2006 Tom Meade +2 more
openalex +1 more source
Mendelian randomization: a premature burial? [PDF]
, 2015 Mendelian randomization is a promising approach to help improve causal inference in observational studies, with widespread potential applications, including to prioritization of pharmacotherapeutic targets for evaluation in RCTs. From its initial proposal the limitations of Mendelian randomization approaches have been widely recognised and discussed ...
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Mendelian Randomization Estimates May Be Inflated
Journal of the American College of Cardiology, 2013 Ference et al. ([1][1]), using a Mendelian randomization approach, show that the genetic effect of a unit change in low-density lipoprotein (LDL) on coronary heart disease (CHD) is much larger than the increase in risk per unit LDL seen prospectively in cohort studies or the similar-sized ...
C Mary, Schooling +3 more
openaire +3 more sources