Results 131 to 140 of about 1,141,533 (358)

‘Mendelian randomization’ equals instrumental variable analysis with genetic instruments [PDF]

, 2008
George L. Wehby, Robert L. Ohsfeldt, Jeffrey C. Murray   +2 more
openalex   +1 more source

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

PLoS Medicine, 2013
A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity.
K. S. Vimaleswaran, D. Berry, Chen Lu, E. Tikkanen, S. Pilz, Linda T. Hiraki, J. Cooper, Z. Dastani, Rui Li, D. Houston, A. Wood, K. Michaëlsson, L. Vandenput, L. Zgaga, L. Yerges-Armstrong, M. McCarthy, J. Dupuis, M. Kaakinen, M. Kleber, K. Jameson, N. Arden, O. Raitakari, J. Viikari, K. Lohman, L. Ferrucci, H. Melhus, E. Ingelsson, L. Byberg, L. Lind, M. Lorentzon, V. Salomaa, H. Campbell, M. Dunlop, B. Mitchell, K. Herzig, A. Pouta, -. Anna, Liisa Hartikainen, E. Streeten, E. Theodoratou, A. Jula, N. Wareham, C. Ohlsson, T. Frayling, S. Kritchevsky, Timothy D Spector, J. B. Richards, T. Lehtimäki, W. Ouwehand, P. Kraft, C. Cooper, W. März, C. Power, R. Loos, Thomas J. Wang, M. Järvelin, J. Whittaker, A. Hingorani, E. Hyppönen   +58 more
semanticscholar   +1 more source

Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al

Arthritis &Rheumatology, EarlyView.
James R. Staley, Olga Giannakopoulou, Gill Holdsworth, Martin Armstrong   +3 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis

BMC Musculoskeletal Disorders
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent an effective strategy for reducing cardiovascular disease risk. Yet, PCSK9’s impact on osteoporosis remains unclear. Hence, we employed Mendelian randomization (MR) analysis for examining PCSK9 inhibitor effects on osteoporosis.
Ding-Qiang Chen, Wen-Bin Xu, Ke-Yi Xiao, Zhi-Qiang Que, Jin-Yi Feng, Nai-Kun Sun, Di-Xin Cai, Gang Rui   +7 more
openaire   +3 more sources

Reply

Arthritis &Rheumatology, EarlyView.
Jie Zheng, George Davey Smith, Jonathan H. Tobias   +2 more
wiley   +1 more source

Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective The gut microbiota (GM) plays a role in epilepsy development via the microbiota–gut–brain axis. However, its relationship with various epilepsy subtypes and its mediating role through immune cells remain unclear. Thus, identifying the GM linked to specific epilepsy subtypes and investigating immune mechanisms to predict epilepsy risk,
Xu Zhang, Zhenlin Yang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis

Brazilian Journal of Medical and Biological Research
The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis.
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang   +4 more
openaire   +3 more sources

Food Addiction Is Strongly Associated With Psychopathology and Reduced Psychological Well‐Being Among Adults Irrespective of BMI

European Eating Disorders Review, EarlyView.
ABSTRACT Background and Aims Food addiction has been linked to psychopathology and reduced psychological well‐being. Here, we investigated whether these associations are mainly driven by food addiction itself or mediated via an increase in BMI. Methods Data stem from a nationwide survey from Denmark (n = 1474 participants).
Christina Horsager, Emil Færk, Jens Meldgaard Bruun, Marlene B. Lauritsen, Søren Dinesen Østergaard   +4 more
wiley   +1 more source

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis

Journal of Psychiatric Research
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation.
Souza-Teodoro, LH, Davies, NM, Warren, HR, Andrade, LHSG, Carvalho, LA   +4 more
openaire   +4 more sources