Results 111 to 120 of about 22,084,160 (163)

Uncovering prognostic markers and therapeutic targets in acute myeloid leukemia: Insights from differential gene expression and Mendelian randomization analysis

Medicine in Omics
The development and prognosis of acute myeloid leukemia (AML) are influenced by multiple factors. This study utilized bioinformatics analysis to explore differentially expressed genes (DEGs) in acute myeloid leukemia (AML) and non-tumor tissues ...
Yaqi Huang, Xiao Zhu, Dongpei Li
doaj   +1 more source

PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis

BMC Musculoskeletal Disorders
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent an effective strategy for reducing cardiovascular disease risk. Yet, PCSK9’s impact on osteoporosis remains unclear. Hence, we employed Mendelian randomization (MR) analysis for examining PCSK9 inhibitor effects on osteoporosis.
Ding-Qiang Chen, Wen-Bin Xu, Ke-Yi Xiao, Zhi-Qiang Que, Jin-Yi Feng, Nai-Kun Sun, Di-Xin Cai, Gang Rui   +7 more
openaire   +3 more sources

The application of mendelian randomization in cancer research: a bibliometric analysis

Discover Oncology
Cancer is a major public health and economic issue faced globally today, significantly affecting human health and life. Due to various constraints, exploring the causal relationship between risk factors and cancer is challenging and not exactly accurate.
Zhongtao Bai, Genlong Zhang
openaire   +3 more sources

Association between a history of hypothyroidism and incident chronic kidney disease and potential mediators: A cohort study with Mendelian randomization analysis

Journal of International Medical Research
Objective To investigate the association between hypothyroidism and incident chronic kidney disease and identify potential mediators. Methods This study included a retrospective cohort and Mendelian randomization analysis.
Yaofang Zhang, Yue Shen, Aiwen Shen, Yuqi Shen, Zhu Zhu, Yining He, Wenji Wang, Xuezhu Li, Xiao Bi, Feng Ding   +9 more
doaj   +1 more source

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis

Journal of Multidisciplinary Healthcare
Pengfei Liu,1 Qiurong Zeng2 1Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of ...
Liu P, Zeng Q
doaj  

Association of Physical Activity with Asthma and Chronic Obstructive Pulmonary Disease and Mediation of Frailty: Mendelian Randomization Analyses

International Journal of COPD
Nanxin Chen,1 Xuejie Si,2 Jun Wang,2 Wenjing Chen2 1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The ...
Chen N, Si X, Wang J, Chen W
doaj  

Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study

Hereditas
Objective To investigate the causal relationship between minerals and vitamins and acute and chronic tubulointerstitial nephritis by Mendelian randomization.
Xiaotan Pan, Zhiyan Guo, Yin Zheng, Cheng Su, Jiabo Chen   +4 more
doaj   +1 more source

Plot of key assumptions for Mendelian randomization analysis.

Plot of key assumptions for Mendelian randomization analysis.
Bin Zhu (182882), Jun Chen (4238), Wenqiang Fu (1599883), Xuelin Jin (543367)   +3 more
core   +1 more source

Causal effects of blood and urinary biomarkers on cancer risk: A Mendelian randomization study

Journal of International Medical Research
Objective Observational studies have linked various serum and urinary biomarkers to cancer risk, but confounding and reverse causation limit causal inference.
Lina Leng, Ying Li
doaj   +1 more source

A Bidirectional Two-Sample Mendelian Randomization Study of Genetic Causality Between Vitamin D Levels and Pemphigus [PDF]

Yanchun Wang,1 Shiping Cheng,2 Huafa Que3 1College of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, People’s Republic of China; 2Department of Dermatology, the Affiliated Hospital of Jiangxi University of Chinese ...
Cheng S, Que H, Wang Y
core